2′-Fluorothymidine (2′-Fluoro-2′-deoxythymidine), a bioisostere of both thymidine (TdR) and methyluridine, is a putative highly selective substrate for thymidine kinase type 2 (TK2)[1].
分子量
260.22
Formula
C10H13FN2O5
CAS 号
122799-38-6
中文名称
2′-氟胸苷
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Wiebe LI, et al. Biochemistry and biology of 2′-Fluoro-2′-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2). Curr Radiopharm. 2012 Jan;5(1):38-46.
2-Deoxy-2-fluoro-L-fucose, an L-fucose analog, is a fucosylation inhibitor. 2-Deoxy-2-fluoro-L-fucose inhibits de novo synthesis of GDP-fucose in mammalian cells. Fucosylation is a relatively well-defined biomarker for progression in many human cancers; for example, pancreatic and hepatocellular carcinoma[1].
体外研究 (In Vitro)
2-Deoxy-2-fluoro-L-fucose (2FF) (100-500 μM)) suppresses fucosylation in 4T1 cells[1]. 2-Deoxy-2-fluoro-L-fucose (100 μM; 4T1 cells) decreases phosphorylation of Smad 1/5 and Smad 2[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
166.15
Formula
C6H11FO4
CAS 号
70763-62-1
中文名称
2-脱氧-2-氟-L-岩藻糖
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
-20°C, protect from light, stored under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶解性数据
In Vitro:
DMSO : 100 mg/mL (601.87 mM; Need ultrasonic)
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
6.0187 mL
30.0933 mL
60.1866 mL
5 mM
1.2037 mL
6.0187 mL
12.0373 mL
10 mM
0.6019 mL
3.0093 mL
6.0187 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
[1]. Herrera H, et al. Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer. Int J Mol Sci. 2019;20(10):2528. Published 2019 May 23.
3′-Fluoro-3′-deoxythymidine (Alovudine) 是 DNA 合成的标志物,其比 18F-Fluorodeoxyglucose (FDG) 更不易受炎症变化的影响,因此在胰腺癌中是更好的生物标志物。
3′-Fluoro-3′-deoxythymidine Chemical Structure
CAS No. : 25526-93-6
规格
价格
是否有货
数量
10 mM * 1 mL in DMSO
¥830
In-stock
25 mg
¥750
In-stock
50 mg
¥1200
In-stock
100 mg
¥1600
In-stock
200 mg
询价
500 mg
询价
* Please select Quantity before adding items.
3′-Fluoro-3′-deoxythymidine 相关产品
•相关化合物库:
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FDA Approved & Pharmacopeial Drug Library
Anti-Pancreatic Cancer Compound Library
生物活性
3′-Fluoro-3′-deoxythymidine (Alovudine) is a marker of DNA synthesis that is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer[1].
Clinical Trial
分子量
244.22
Formula
C10H13FN2O4
CAS 号
25526-93-6
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Challapalli A, et al. 3′-Deoxy-3′-18F-fluorothymidine positron emission tomography as an early predictor of disease progression in patients with advanced and metastatic pancreatic cancer. Eur J Nucl Med Mol Imaging. 2015 May;42(6):831-40.
5-Fluoro-2′-deoxycytidine,一种氟嘧啶核苷类似物,是 DNA 甲基转移酶 (DNMT) 抑制剂。5-Fluoro-2′-deoxycytidine 是有效的胸苷酸合酶抑制剂 5-fluoro-2′-dUMP 的肿瘤选择性前药。
5-Fluoro-2′-deoxycytidine Chemical Structure
CAS No. : 10356-76-0
规格
价格
是否有货
数量
10 mM * 1 mL in DMSO
¥550
In-stock
5 mg
¥500
In-stock
10 mg
询价
50 mg
询价
* Please select Quantity before adding items.
5-Fluoro-2′-deoxycytidine 相关产品
•相关化合物库:
Covalent Screening Library Plus
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Epigenetics Compound Library
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Nucleotide Compound Library
Anti-Blood Cancer Compound Library
Transcription Factor Targeted Library
生物活性
5-Fluoro-2′-deoxycytidine, a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase (DNMT) inhibitor. 5-Fluoro-2′-deoxycytidine is a tumor-selective prodrug of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP[1][2].
IC50 & Target
DNA methyltransferase (DNMT)[1]
Clinical Trial
分子量
245.21
Formula
C9H12FN3O4
CAS 号
10356-76-0
中文名称
5-氟脱氧胞苷;5-氟-2′-脱氧胞苷
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Beumer JH, et, al. Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine in mice. Clin Cancer Res. 2006 Dec 15;12(24):7483-91.
[2]. Osterman DG, et, al. 5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase. Biochemistry. 1988 Jul 12;27(14):5204-10.