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生物活性分子抑制剂MC-GGFG-DX8951

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
MC-GGFG-DX8951 

MC-GGFG-DX8951 是一种抗体偶联药物 (drug-linker conjugate for ADC)，具有抗肿瘤活性，由DNA拓扑异构酶 I 抑制剂 DX8951 和蛋白酶可降解 (cleavable) 的 MC-GGFG 连接而成。

MC-GGFG-DX8951

MC-GGFG-DX8951 Chemical Structure

CAS No. : 1600418-29-8

规格 价格 是否有货 数量
5 mg ￥9000 In-stock
10 mg ￥15000 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

生物活性

MC-GGFG-DX8951 is a drug-linker conjugate for ADC with antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the protease cleavable MC-GGFG linker[1].

IC50 & Target

Camptothecins

 

分子量

946.97

Formula

C49H51FN8O11
CAS 号

1600418-29-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (52.80 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0560 mL 5.2800 mL 10.5600 mL
5 mM 0.2112 mL 1.0560 mL 2.1120 mL
10 mM 0.1056 mL 0.5280 mL 1.0560 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Nakada T, et al. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1542-1545.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

DBCO-PEG4-GGFG-DX8951

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

DBCO-PEG4-GGFG-DX8951 

DBCO-PEG4-GGFG-DX8951 是抗体-药物偶联物的一部分，由 DNA 拓扑异构酶 I 抑制剂 DX8951 和不可降解的 ADC linker DBCO-PEG4-GGFG 连接而成。

DBCO-PEG4-GGFG-DX8951

DBCO-PEG4-GGFG-DX8951 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

DBCO-PEG4-GGFG-DX8951 is a drug-linker conjugate for ADC with potent antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the non-cleavable ADC linker DBCO-PEG4-GGFG[1].

IC50 & Target

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linke[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1375.45

Formula

C72H79FN10O17
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anish Thomas, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17(6):e254-e262.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

DBCO-PEG4-GGFG-DX8951

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

DBCO-PEG4-GGFG-DX8951 

DBCO-PEG4-GGFG-DX8951 是抗体-药物偶联物的一部分，由 DNA 拓扑异构酶 I 抑制剂 DX8951 和不可降解的 ADC linker DBCO-PEG4-GGFG 连接而成。

DBCO-PEG4-GGFG-DX8951

DBCO-PEG4-GGFG-DX8951 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

DBCO-PEG4-GGFG-DX8951 is a drug-linker conjugate for ADC with potent antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the non-cleavable ADC linker DBCO-PEG4-GGFG[1].

IC50 & Target

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linke[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1375.45

Formula

C72H79FN10O17
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anish Thomas, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17(6):e254-e262.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

DBCO-PEG4-GGFG-DX8951

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

DBCO-PEG4-GGFG-DX8951 

DBCO-PEG4-GGFG-DX8951 是抗体-药物偶联物的一部分，由 DNA 拓扑异构酶 I 抑制剂 DX8951 和不可降解的 ADC linker DBCO-PEG4-GGFG 连接而成。

DBCO-PEG4-GGFG-DX8951

DBCO-PEG4-GGFG-DX8951 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

DBCO-PEG4-GGFG-DX8951 is a drug-linker conjugate for ADC with potent antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the non-cleavable ADC linker DBCO-PEG4-GGFG[1].

IC50 & Target

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linke[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1375.45

Formula

C72H79FN10O17
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Anish Thomas, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17(6):e254-e262.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务