hDDAH-1-IN-1

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hDDAH-1-IN-1

hDDAH-1-IN-1 (compound 8a) 是一种高效、选择性的非氨基酸 hDDAH-1 催化位点抑制剂，K_i 值为 18 μM。

hDDAH-1-IN-1 Chemical Structure

CAS No. : 1229238-69-0

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生物活性	hDDAH-1-IN-1 (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a K_i of 18 µM^[1].
IC₅₀ & Target	Ki: 18 µM (hDDAH-1)^[1]
分子量	188.27
Formula	C₈H₂₀N₄O
CAS 号	1229238-69-0
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Lunk I, et al. Discovery of N-(4-Aminobutyl)-N’-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1). J Med Chem. 2019 Dec 31.

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hDDAH-1-IN-1 TFA

hDDAH-1-IN-1 TFA

hDDAH-1-IN-1TFA (compound 8a) 是一种高效、选择性的非氨基酸 hDDAH-1 催化位点抑制剂，K_i 值为 18 μM。

hDDAH-1-IN-1 TFA Chemical Structure

CAS No. : 1229238-70-3

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生物活性	hDDAH-1-IN-1 TFA (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a K_i of 18 µM^[1].
体外研究 (In Vitro)	hDDAH-1-IN-1 TFA potently inhibits hDDAH-1 (K_i = 18 µM) without significantly affecting NOSs and arginase^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	416.32
Formula	C₁₂H₂₂F₆N₄O₅
CAS 号	1229238-70-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Lunk I, et al. Discovery of N-(4-Aminobutyl)-N’-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1). J Med Chem. 2019 Dec 31.

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hDDAH-1-IN-2 sulfate

hDDAH-1-IN-2 是一种选择性、具有口服活性的人二甲基精氨酸二甲基氨基水合-1 (hDDAH-1)。hDDAH-1-IN-2 对细胞毒性/活力良好。

hDDAH-1-IN-2 sulfate Chemical Structure

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生物活性	hDDAH-1-IN-2 is a selective, orally active human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) inhibitor. hDDAH-1-IN-2 reveals an excellent profile regarding cell toxicity/viability^[1].
分子量	400.43
Formula	C₈H₂₄N₄O₁₀S₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Lunk I, et al. Discovery of N-(4-Aminobutyl)-N’-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1).J Med Chem. 2020 Jan 9;63(1):425-432.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务