ICG-OSu(Synonyms: ICG NHS ester)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

ICG-OSu (Synonyms: ICG NHS ester)

ICG-OSu (ICG NHS ester) 是一种近红外荧光剂,具有胺反应性,被广泛用于体内成像探针的设计。

ICG-OSu(Synonyms: ICG NHS ester)

ICG-OSu Chemical Structure

CAS No. : 1622335-40-3

规格 价格 是否有货
5 mg ¥5100 询问价格 & 货期
10 mg ¥8200 询问价格 & 货期
25 mg ¥16800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

ICG-OSu (ICG NHS ester), a near-infrared fluorescent agent, is amine-reactive and has been widely used to design in vivo imaging probes[1].

分子量

828.03

Formula

C49H53N3O7S

CAS 号

1622335-40-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

DMSO : 25 mg/mL (30.19 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2077 mL 6.0384 mL 12.0769 mL
5 mM 0.2415 mL 1.2077 mL 2.4154 mL
10 mM 0.1208 mL 0.6038 mL 1.2077 mL

参考文献
  • [1]. Zhou Y, et al. A Novel Near-Infrared Fluorescent Probe TMTP1-PEG4-ICG for in Vivo Tumor Imaging. Bioconjug Chem. 2018;29(12):4119-4126.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

ICG-OSu(Synonyms: ICG NHS ester)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

ICG-OSu (Synonyms: ICG NHS ester)

ICG-OSu (ICG NHS ester) 是一种近红外荧光剂,具有胺反应性,被广泛用于体内成像探针的设计。

ICG-OSu(Synonyms: ICG NHS ester)

ICG-OSu Chemical Structure

CAS No. : 1622335-40-3

规格 价格 是否有货
5 mg ¥5100 询问价格 & 货期
10 mg ¥8200 询问价格 & 货期
25 mg ¥16800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

ICG-OSu (ICG NHS ester), a near-infrared fluorescent agent, is amine-reactive and has been widely used to design in vivo imaging probes[1].

分子量

828.03

Formula

C49H53N3O7S

CAS 号

1622335-40-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

DMSO : 25 mg/mL (30.19 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2077 mL 6.0384 mL 12.0769 mL
5 mM 0.2415 mL 1.2077 mL 2.4154 mL
10 mM 0.1208 mL 0.6038 mL 1.2077 mL

参考文献
  • [1]. Zhou Y, et al. A Novel Near-Infrared Fluorescent Probe TMTP1-PEG4-ICG for in Vivo Tumor Imaging. Bioconjug Chem. 2018;29(12):4119-4126.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

ICG-OSu(Synonyms: ICG NHS ester)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

ICG-OSu (Synonyms: ICG NHS ester)

ICG-OSu (ICG NHS ester) 是一种近红外荧光剂,具有胺反应性,被广泛用于体内成像探针的设计。

ICG-OSu(Synonyms: ICG NHS ester)

ICG-OSu Chemical Structure

CAS No. : 1622335-40-3

规格 价格 是否有货
5 mg ¥5100 询问价格 & 货期
10 mg ¥8200 询问价格 & 货期
25 mg ¥16800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

ICG-OSu (ICG NHS ester), a near-infrared fluorescent agent, is amine-reactive and has been widely used to design in vivo imaging probes[1].

分子量

828.03

Formula

C49H53N3O7S

CAS 号

1622335-40-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

DMSO : 25 mg/mL (30.19 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2077 mL 6.0384 mL 12.0769 mL
5 mM 0.2415 mL 1.2077 mL 2.4154 mL
10 mM 0.1208 mL 0.6038 mL 1.2077 mL

参考文献
  • [1]. Zhou Y, et al. A Novel Near-Infrared Fluorescent Probe TMTP1-PEG4-ICG for in Vivo Tumor Imaging. Bioconjug Chem. 2018;29(12):4119-4126.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

ICG-amine

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

ICG-amine 

ICG amine 作为一种近红外荧光探针,不需要冷凝剂就能与氨基酸残基结合。ICG 是三碳菁染料。

ICG-amine

ICG-amine Chemical Structure

CAS No. : 1686147-55-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ICG amine, as a near-infrared fluorescent probe, binds to amino acid residues without condensing agents. ICG is a tricarbocyanine dye[1].

体外研究
(In Vitro)

ICG is a tricarbocyanine dye[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

829.14

Formula

C51H64N4O4S

CAS 号

1686147-55-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Badaracco AG, et al. Indocyanine green modified silica shells for colon tumor marking. Appl Surf Sci. 2020;499:143885.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

ICG-amine

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

ICG-amine 

ICG amine 作为一种近红外荧光探针,不需要冷凝剂就能与氨基酸残基结合。ICG 是三碳菁染料。

ICG-amine

ICG-amine Chemical Structure

CAS No. : 1686147-55-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ICG amine, as a near-infrared fluorescent probe, binds to amino acid residues without condensing agents. ICG is a tricarbocyanine dye[1].

体外研究
(In Vitro)

ICG is a tricarbocyanine dye[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

829.14

Formula

C51H64N4O4S

CAS 号

1686147-55-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Badaracco AG, et al. Indocyanine green modified silica shells for colon tumor marking. Appl Surf Sci. 2020;499:143885.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

ICG-amine

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

ICG-amine 

ICG amine 作为一种近红外荧光探针,不需要冷凝剂就能与氨基酸残基结合。ICG 是三碳菁染料。

ICG-amine

ICG-amine Chemical Structure

CAS No. : 1686147-55-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ICG amine, as a near-infrared fluorescent probe, binds to amino acid residues without condensing agents. ICG is a tricarbocyanine dye[1].

体外研究
(In Vitro)

ICG is a tricarbocyanine dye[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

829.14

Formula

C51H64N4O4S

CAS 号

1686147-55-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Badaracco AG, et al. Indocyanine green modified silica shells for colon tumor marking. Appl Surf Sci. 2020;499:143885.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

ICG-001

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

ICG-001  纯度: 99.83%

ICG-001 是 β-catenin/TCF 介导的转录抑制剂。 ICG-001 特异性结合 CREB 蛋白起作用,IC50 为3 μM。ICG-001 选择性地阻断 β-catenin/CBP 相互作用而不干扰 β-catenin/p300 相互作用。

ICG-001

ICG-001 Chemical Structure

CAS No. : 780757-88-2

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥1112 In-stock
5 mg ¥921 In-stock
10 mg ¥1200 In-stock
50 mg ¥4500 In-stock
100 mg ¥8184 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

ICG-001 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Stem Cell Signaling Compound Library
  • Wnt/Hedgehog/Notch Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Differentiation Inducing Compound Library
  • Cytoskeleton Compound Library
  • Neuroprotective Compound Library
  • Anti-Breast Cancer Compound Library
  • Transcription Factor Targeted Library
  • Anti-Liver Cancer Compound Library
  • Anti-Colorectal Cancer Compound Library

生物活性

ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. ICG-001 works by specifically binding to cyclic AMP response element-binding protein with an IC50 of 3 μM. ICG-001 selectively blocks the β-catenin/CBP interaction without interfering with the β-catenin/p300 interaction.

IC50 & Target

IC50: 3 μM (CBP)

体外研究
(In Vitro)

ICG-001 (5μM) inhibits leptin-induced EMT, invasion and tumorsphere formation in MCF7 cells[1]. ICG-001 can phenotypically rescue normal nerve growth factor (NGF)-induced neuronal differentiation and neurite outgrowth in the presenilin-1 mutant cells, emphasizing the importance of the TCF/β-catenin signaling pathway on neurite outgrowth and neuronal differentiation[2]. ICG-001 (25μM) treatment reduces the steady-state levels of Survivin and Cyclin D1 RNA and protein in SW480 cells, both of which can be up-regulated by β-catenin. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, and reduces in vitro growth of colon carcinoma cells[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

ICG-001 (5 mg/kg per day) significantly inhibits beta-catenin signaling in mice, while concurrently preserving the epithelium[2]. Administration of a water-soluble analog of ICG-001 for 9 weeks reduces the formation of colon and small intestinal polyps by 42% as effectively as the nonsteroidal antiinflammatory agent MK-231, which has consistently demonstrated efficacy in this model. ICG-001 (150 mg/kg, i.v.) demonstrates a dramatic reduction in tumor volume over the 19-day course of treatment, with no mortality or weight loss in the SW620 nude mouse xenograft model of tumor regression[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

548.63

Formula

C33H32N4O4

CAS 号

780757-88-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 50 mg/mL (91.14 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8227 mL 9.1136 mL 18.2272 mL
5 mM 0.3645 mL 1.8227 mL 3.6454 mL
10 mM 0.1823 mL 0.9114 mL 1.8227 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.56 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (4.56 mM); Suspended solution; Need ultrasonic and warming

    此方案可获得 2.5 mg/mL (4.56 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.56 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Yan D, et al, Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. J Biol Chem, 2012, 287(11), 8598-8612.

    [2]. Henderson WR Jr, et al, Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA, 2010, 107(32), 14309-14314.

    [3]. Emami KH, et al. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci USA, 2004, 101(34), 12682-12687.

    [4]. Liu Y, et al. ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population. J Exp Clin Cancer Res. 2017 Sep 11;36(1):125.

Cell Assay
[2]

To evaluate effects of ICG-001 on α-SMA and collagen type 1 expression, RLE-6TN cells are treated with TGF-β1 (0.25 ng/mL) in the presence or absence of ICG-001 (5.0 μM). After 24 h, cells are harvested and mRNA isolated for analysis by qPCR. RNA is reverse-transcribed using SuperScript reverse transcriptase. Quantitative PCR is performed with SYBR-Green PCR using Real-Time PCR System HT7900. The amplification protocol is set as follows: 95°C denaturation for 10 min followed by 40 cycles of 15-s denaturation at 95°C, 1 min of annealing/extension, and data collection at 60°C.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[3]

Seven-week-old male C57BL/6J-ApcMin/+and WT C57BL/6J mice are treated orally for 9 weeks with ICG-001a (300 mg/kg per day) or vehicle (1% carboxymethylcellulose), once daily, six times per week. MK-231 is administered in drinking water (160 ppm, dissolved in 8 mM Na2PO4 buffer, pH 7.6). At 16 weeks, the polyp number is counted manually by using a dissecting microscope.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Yan D, et al, Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways. J Biol Chem, 2012, 287(11), 8598-8612.

    [2]. Henderson WR Jr, et al, Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA, 2010, 107(32), 14309-14314.

    [3]. Emami KH, et al. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci USA, 2004, 101(34), 12682-12687.

    [4]. Liu Y, et al. ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population. J Exp Clin Cancer Res. 2017 Sep 11;36(1):125.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

ICG-Sulfo-OSu sodium

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

ICG-Sulfo-OSu sodium 

ICG-Sulfo-OSu sodium 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

ICG-Sulfo-OSu sodium

ICG-Sulfo-OSu sodium Chemical Structure

CAS No. : 190714-28-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

930.07

Formula

C49H52N3NaO10S2

CAS 号

190714-28-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

ICG-Sulfo-OSu sodium

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

ICG-Sulfo-OSu sodium 

ICG-Sulfo-OSu sodium 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

ICG-Sulfo-OSu sodium

ICG-Sulfo-OSu sodium Chemical Structure

CAS No. : 190714-28-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

930.07

Formula

C49H52N3NaO10S2

CAS 号

190714-28-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

ICG-Sulfo-OSu sodium

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

ICG-Sulfo-OSu sodium 

ICG-Sulfo-OSu sodium 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

ICG-Sulfo-OSu sodium

ICG-Sulfo-OSu sodium Chemical Structure

CAS No. : 190714-28-4

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生物活性

ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

930.07

Formula

C49H52N3NaO10S2

CAS 号

190714-28-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务