Impurity C of Calcitriol(Synonyms: PRE-骨化三醇PTAD加合物)

发表于2024年2月13日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Impurity C of Calcitriol (Synonyms: PRE-骨化三醇PTAD加合物) 纯度: 99.98%

Impurity C of Calcitriol是Calcitriol的杂质，Calcitriol是维生素D3的活性代谢物，能激活维生素D受体。

Impurity C of Calcitriol Chemical Structure

CAS No. : 86307-44-0

规格	价格	是否有货
1 mg	￥4000	In-stock
5 mg	￥12000	In-stock
10 mg	￥16500	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

Impurity C of Calcitriol 相关产品

•相关化合物库:

Bioactive Compound Library Plus

生物活性	Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). IC50 value: Target: vitamin D receptor Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
分子量	591.78
Formula	C₃₅H₄₉N₃O₅
CAS 号	86307-44-0
中文名称	PRE-骨化三醇PTAD加合物；骨化三醇杂质 C
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004) [2]. Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373. [3]. Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23. [4]. Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M. Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.

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Budesonide impurity C(Synonyms: 布地奈德杂质C)

发表于2024年1月30日由上海金畔生物科技有限公司

Budesonide impurity C (Synonyms: 布地奈德杂质C)

Budesonide impurity C 是 Budesonide 的一种杂质。Budesonide 是一种吸入型糖皮质类固醇，一种具有口服活性的糖皮质激素受体 (glucocorticoid receptor) 激动剂。

Budesonide impurity C Chemical Structure

CAS No. : 1040085-99-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist^[1]^[2].
体外研究 (In Vitro)	Budesonide is selective for human glucocorticoid receptor (hGR; EC₅₀=45.7 pM) over mineralocorticoid receptors (EC₅₀=7,620 pM) in CV-1 cells^[1]. Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells)^[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	430.53
Formula	C₂₅H₃₄O₆
CAS 号	1040085-99-1
中文名称	布地奈德杂质C
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Patrizia Ferraboschi, et al. Estimation and Characterisation of Budesonide Tablets Impurities. J Pharm Biomed Anal. 2008 Jul 15;47(3):636-40. [2]. Claudia Grossmann, et al. Transactivation via the Human Glucocorticoid and Mineralocorticoid Receptor by Therapeutically Used Steroids in CV-1 Cells: A Comparison of Their Glucocorticoid and Mineralocorticoid Properties. Eur J Endocrinol. 2004 Sep;151(3):397-406.

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Budesonide impurity C(Synonyms: 布地奈德杂质C)

发表于2024年1月30日由上海金畔生物科技有限公司

Budesonide impurity C (Synonyms: 布地奈德杂质C)

Budesonide impurity C 是 Budesonide 的一种杂质。Budesonide 是一种吸入型糖皮质类固醇，一种具有口服活性的糖皮质激素受体 (glucocorticoid receptor) 激动剂。

Budesonide impurity C Chemical Structure

CAS No. : 1040085-99-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist^[1]^[2].
体外研究 (In Vitro)	Budesonide is selective for human glucocorticoid receptor (hGR; EC₅₀=45.7 pM) over mineralocorticoid receptors (EC₅₀=7,620 pM) in CV-1 cells^[1]. Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells)^[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	430.53
Formula	C₂₅H₃₄O₆
CAS 号	1040085-99-1
中文名称	布地奈德杂质C
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Patrizia Ferraboschi, et al. Estimation and Characterisation of Budesonide Tablets Impurities. J Pharm Biomed Anal. 2008 Jul 15;47(3):636-40. [2]. Claudia Grossmann, et al. Transactivation via the Human Glucocorticoid and Mineralocorticoid Receptor by Therapeutically Used Steroids in CV-1 Cells: A Comparison of Their Glucocorticoid and Mineralocorticoid Properties. Eur J Endocrinol. 2004 Sep;151(3):397-406.

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Budesonide impurity C(Synonyms: 布地奈德杂质C)

发表于2024年1月30日由上海金畔生物科技有限公司

Budesonide impurity C (Synonyms: 布地奈德杂质C)

Budesonide impurity C 是 Budesonide 的一种杂质。Budesonide 是一种吸入型糖皮质类固醇，一种具有口服活性的糖皮质激素受体 (glucocorticoid receptor) 激动剂。

Budesonide impurity C Chemical Structure

CAS No. : 1040085-99-1

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist^[1]^[2].
体外研究 (In Vitro)	Budesonide is selective for human glucocorticoid receptor (hGR; EC₅₀=45.7 pM) over mineralocorticoid receptors (EC₅₀=7,620 pM) in CV-1 cells^[1]. Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells)^[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	430.53
Formula	C₂₅H₃₄O₆
CAS 号	1040085-99-1
中文名称	布地奈德杂质C
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Patrizia Ferraboschi, et al. Estimation and Characterisation of Budesonide Tablets Impurities. J Pharm Biomed Anal. 2008 Jul 15;47(3):636-40. [2]. Claudia Grossmann, et al. Transactivation via the Human Glucocorticoid and Mineralocorticoid Receptor by Therapeutically Used Steroids in CV-1 Cells: A Comparison of Their Glucocorticoid and Mineralocorticoid Properties. Eur J Endocrinol. 2004 Sep;151(3):397-406.

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Mesalamine impurity P

发表于2024年1月27日由上海金畔生物科技有限公司

Mesalamine impurity P

Mesalamine impurity P 是 Mesalamine (HY-15027) 的杂质。5-Aminosalicylic acid (Mesalamine) 是一种特异性的 PPARγ 激动剂，还抑制 p21-激活激酶 1 (PAK1) 和 NF-κB。

Mesalamine impurity P Chemical Structure

CAS No. : 887256-40-8

规格	价格	是否有货
1 mg	￥3000	询问价格 & 货期

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生物活性

Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB^[1].

IC₅₀ & Target^[1]

PPAR

PAK1

NF-κB

分子量

309.29

Formula

C₁₃H₁₁NO₆S

CAS 号

887256-40-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Kyle Dammann, et al.PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation.Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.

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Mesalamine impurity P

发表于2024年1月26日由上海金畔生物科技有限公司

Mesalamine impurity P

Mesalamine impurity P 是 Mesalamine (HY-15027) 的杂质。5-Aminosalicylic acid (Mesalamine) 是一种特异性的 PPARγ 激动剂，还抑制 p21-激活激酶 1 (PAK1) 和 NF-κB。

Mesalamine impurity P Chemical Structure

CAS No. : 887256-40-8

规格	价格	是否有货
1 mg	￥3000	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

IC₅₀ & Target^[1]

PPAR

PAK1

NF-κB

分子量

309.29

Formula

C₁₃H₁₁NO₆S

CAS 号

887256-40-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Kyle Dammann, et al.PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation.Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.

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Mesalamine impurity P

发表于2024年1月26日由上海金畔生物科技有限公司

Mesalamine impurity P

Mesalamine impurity P 是 Mesalamine (HY-15027) 的杂质。5-Aminosalicylic acid (Mesalamine) 是一种特异性的 PPARγ 激动剂，还抑制 p21-激活激酶 1 (PAK1) 和 NF-κB。

Mesalamine impurity P Chemical Structure

CAS No. : 887256-40-8

规格	价格	是否有货
1 mg	￥3000	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

IC₅₀ & Target^[1]

PPAR

PAK1

NF-κB

分子量

309.29

Formula

C₁₃H₁₁NO₆S

CAS 号

887256-40-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Kyle Dammann, et al.PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation.Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.

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Ciprofibrate impurity A

发表于2024年1月26日由上海金畔生物科技有限公司

Ciprofibrate impurity A

Ciprofibrate impurity A 是 Ciprofibrate 的一种杂质。Ciprofibrate 是一种有效的过氧化物酶体 (peroxisome) 增殖物，可增加 PPARalpha 的磷酸化水平。

Ciprofibrate impurity A Chemical Structure

CAS No. : 1474058-89-3

规格	价格	是否有货
1 mg	￥1200	询问价格 & 货期
5 mg	￥3500	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate (Win35833) is a potent peroxisome proliferator, increases the phosphorylation level of the PPARalpha^[1].

IC₅₀ & Target^[1]

PPARα

分子量

206.24

Formula

C₁₂H₁₄O₃

CAS 号

1474058-89-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Passilly, P., et al., Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol, 1999. 58(6): p. 1001-8.

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Ciprofibrate impurity A

发表于2024年1月26日由上海金畔生物科技有限公司

Ciprofibrate impurity A

Ciprofibrate impurity A 是 Ciprofibrate 的一种杂质。Ciprofibrate 是一种有效的过氧化物酶体 (peroxisome) 增殖物，可增加 PPARalpha 的磷酸化水平。

Ciprofibrate impurity A Chemical Structure

CAS No. : 1474058-89-3

规格	价格	是否有货
1 mg	￥1200	询问价格 & 货期
5 mg	￥3500	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate (Win35833) is a potent peroxisome proliferator, increases the phosphorylation level of the PPARalpha^[1].

IC₅₀ & Target^[1]

PPARα

分子量

206.24

Formula

C₁₂H₁₄O₃

CAS 号

1474058-89-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Passilly, P., et al., Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol, 1999. 58(6): p. 1001-8.

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Ciprofibrate impurity A

发表于2024年1月26日由上海金畔生物科技有限公司

Ciprofibrate impurity A

Ciprofibrate impurity A 是 Ciprofibrate 的一种杂质。Ciprofibrate 是一种有效的过氧化物酶体 (peroxisome) 增殖物，可增加 PPARalpha 的磷酸化水平。

Ciprofibrate impurity A Chemical Structure

CAS No. : 1474058-89-3

规格	价格	是否有货
1 mg	￥1200	询问价格 & 货期
5 mg	￥3500	询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate (Win35833) is a potent peroxisome proliferator, increases the phosphorylation level of the PPARalpha^[1].

IC₅₀ & Target^[1]

PPARα

分子量

206.24

Formula

C₁₂H₁₄O₃

CAS 号

1474058-89-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Passilly, P., et al., Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol, 1999. 58(6): p. 1001-8.

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Ciprofibrate impurity A-d4

发表于2023年12月20日由上海金畔生物科技有限公司

Ciprofibrate impurity A-d4

Ciprofibrate impurity A-d4 是 Ciprofibrate impurity A 的氘代物。Ciprofibrate impurity A 是 Ciprofibrate 的一种杂质。Ciprofibrate 是一种有效的过氧化物酶体 (peroxisome) 增殖物，可增加 PPARalpha 的磷酸化水平。

Ciprofibrate impurity A-d4 Chemical Structure

CAS No. : 2733843-01-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Ciprofibrate impurity A-d4 is the deuterium labeled Ciprofibrate impurity A. Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate (Win35833) is a potent peroxisome proliferator, increases the phosphorylation level of the PPARalpha^[1].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	210.26
Formula	C₁₂H₁₀D₄O₃
CAS 号	2733843-01-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Passilly, P., et al., Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol, 1999. 58(6): p. 1001-8.

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Ciprofibrate impurity A-d4

发表于2023年12月20日由上海金畔生物科技有限公司

Ciprofibrate impurity A-d4

Ciprofibrate impurity A-d4 Chemical Structure

CAS No. : 2733843-01-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Ciprofibrate impurity A-d4 is the deuterium labeled Ciprofibrate impurity A. Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate (Win35833) is a potent peroxisome proliferator, increases the phosphorylation level of the PPARalpha^[1].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	210.26
Formula	C₁₂H₁₀D₄O₃
CAS 号	2733843-01-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Passilly, P., et al., Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol, 1999. 58(6): p. 1001-8.

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Ciprofibrate impurity A-d4

发表于2023年12月20日由上海金畔生物科技有限公司

Ciprofibrate impurity A-d4

Ciprofibrate impurity A-d4 Chemical Structure

CAS No. : 2733843-01-9

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	Ciprofibrate impurity A-d4 is the deuterium labeled Ciprofibrate impurity A. Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate (Win35833) is a potent peroxisome proliferator, increases the phosphorylation level of the PPARalpha^[1].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	210.26
Formula	C₁₂H₁₀D₄O₃
CAS 号	2733843-01-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Passilly, P., et al., Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol, 1999. 58(6): p. 1001-8.

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HDAC-IN-7(Synonyms: Chidamide impurity)

发表于2023年11月17日由上海金畔生物科技有限公司

HDAC-IN-7 (Synonyms: Chidamide impurity)

HDAC-IN-7 (Chidamide impurity) 是 Chidamide 的一种杂质。Chidamide 是一种有效的，可口服的 HDAC 第 I 类 HDAC1/2/3 和第 IIb 类 HDAC10 抑制剂。

HDAC-IN-7 Chemical Structure

CAS No. : 743420-02-2

规格	价格	是否有货
2 mg	￥1166	询问价格 & 货期
5 mg	￥1750	询问价格 & 货期
10 mg	￥3100	询问价格 & 货期
50 mg	￥12000	询问价格 & 货期

* Please select Quantity before adding items.

HDAC-IN-7 相关产品

•相关化合物库:

FDA-Approved Drug Library Mini

生物活性

HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor.

分子量

390.41

Formula

C₂₂H₁₉FN₄O₂

CAS 号

743420-02-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

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Impurity F of Calcipotriol

发表于2023年11月5日由上海金畔生物科技有限公司

Impurity F of Calcipotriol 纯度: 99.40%

Impurity F of Calcipotriol是钙泊三醇的杂质，钙泊三醇是1,25-Dihydroxyvitamin D3类似物。

Impurity F of Calcipotriol Chemical Structure

CAS No. : 112875-61-3

规格	价格	是否有货
1 mg	￥9207	In-stock
5 mg		询价
10 mg		询价

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Bioactive Compound Library Plus

生物活性	Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value: Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.
分子量	641.13
Formula	C₃₉H₆₈O₃Si₂
CAS 号	112875-61-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, protect from light, stored under nitrogen *该产品在溶液状态不稳定，建议您现用现配，即刻使用。
参考文献	[1]. Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240. [2]. Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829. [3]. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111 [4]. Lise Binderup,, Erik Bramm. Effects of a novel vitamin D analogue MC 903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochemical Pharmacology. Volume 37, Issue 5, 1 March 1988, Pages 889-895

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HDAC-IN-7(Synonyms: Chidamide impurity)

发表于2023年11月5日由上海金畔生物科技有限公司

HDAC-IN-7 (Synonyms: Chidamide impurity)

HDAC-IN-7 (Chidamide impurity) 是 Chidamide 的一种杂质。Chidamide 是一种有效的，可口服的 HDAC 第 I 类 HDAC1/2/3 和第 IIb 类 HDAC10 抑制剂。

HDAC-IN-7 Chemical Structure

CAS No. : 743420-02-2

规格	价格	是否有货
2 mg	￥1166	询问价格 & 货期
5 mg	￥1750	询问价格 & 货期
10 mg	￥3100	询问价格 & 货期
50 mg	￥12000	询问价格 & 货期

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FDA-Approved Drug Library Mini

生物活性

HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor.

分子量

390.41

Formula

C₂₂H₁₉FN₄O₂

CAS 号

743420-02-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

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Afatinib impurity 11

发表于2023年10月7日由上海金畔生物科技有限公司

Afatinib impurity 11 纯度: 99.10%

Afatinib impurity 11 是 Afatinib 的一种杂质，Afatinib 是一种不可逆的 EGFR 家族抑制剂，抑制 EGFR^wt，EGFR^L858R，EGFR^L858R/T790M 和 HER2 的 IC₅₀ 分别为 0.5 nM，0.4 nM，10 nM 和 14 nM。

Afatinib impurity 11 Chemical Structure

CAS No. : 1402086-20-7

规格	价格	是否有货
1 mg	￥1200	In-stock
5 mg	￥3500	In-stock
10 mg		询价
50 mg		询价

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Covalent Screening Library
Differentiation Inducing Compound Library
Anti-Hepatitis C Virus Compound Library
Anti-Lung Cancer Compound Library
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Anti-Colorectal Cancer Compound Library

生物活性

Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC₅₀s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR^wt, EGFR^L858R, EGFR^L858R/T790M and HER2, respectively^[1].

分子量

428.84

Formula

C₂₁H₁₈ClFN₄O₃

CAS 号

1402086-20-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

DMSO : 12.5 mg/mL (29.15 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3319 mL	11.6594 mL	23.3187 mL
5 mM	0.4664 mL	2.3319 mL	4.6637 mL
10 mM	0.2332 mL	1.1659 mL	2.3319 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 4.25 mg/mL (9.91 mM); Suspended solution; Need ultrasonic

此方案可获得 4.25 mg/mL (9.91 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 42.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2 mg/mL (4.66 mM); Clear solution

此方案可获得 ≥ 2 mg/mL (4.66 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 20.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11.

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Impurity B of Calcitriol(Synonyms: 1β,25-Dihydroxyvitamin-D3; 1-Epicalcitriol)

发表于2023年9月20日由上海金畔生物科技有限公司

Impurity B of Calcitriol (Synonyms: 1β,25-Dihydroxyvitamin-D3; 1-Epicalcitriol) 纯度: 98.04%

Impurity B of Calcitriol是Calcitriol的杂质，Calcitriol是维生素D3的活性代谢物，能激活维生素D受体。

Impurity B of Calcitriol Chemical Structure

CAS No. : 66791-71-7

规格	价格	是否有货
1 mg	￥8000	In-stock
5 mg	￥25000	In-stock
10 mg	￥31900	In-stock
50 mg		询价
100 mg		询价

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Bioactive Compound Library Plus

生物活性

Impurity B of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). IC50 value: Target: vitamin D receptor Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions. Calcitriol stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Calcitriol (1,25-Dihydroxyvitamin D3; Rocaltrol )exhibits antitumor activity; Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

分子量

416.64

Formula

C₂₇H₄₄O₃

CAS 号

66791-71-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (240.02 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4002 mL	12.0008 mL	24.0015 mL
5 mM	0.4800 mL	2.4002 mL	4.8003 mL
10 mM	0.2400 mL	1.2001 mL	2.4002 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (6.00 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (6.00 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (6.00 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004)

[2]. Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373.

[3]. Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.

[4]. Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M. Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.

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MC 1046(Synonyms: Impurity A of Calcipotriol)

发表于2023年9月11日由上海金畔生物科技有限公司

MC 1046 (Synonyms: Impurity A of Calcipotriol) 纯度: 91.48%

MC 1046(Impurity A of Calcipotriol)是钙泊三醇的杂质，钙泊三醇是1,25-Dihydroxyvitamin D3类似物。

MC 1046 Chemical Structure

CAS No. : 126860-83-1

规格	价格	是否有货
1 mg	￥5000	In-stock
5 mg		询价
10 mg		询价

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MC 1046 相关产品

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Bioactive Compound Library Plus

生物活性	MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value: Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.
分子量	410.59
Formula	C₂₇H₃₈O₃
CAS 号	126860-83-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light, stored under nitrogen *该产品在溶液状态不稳定，建议您现用现配，即刻使用。
参考文献	[1]. Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240. [2]. Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829. [3]. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111 [4]. P.J. Marie, D. Connes, M. Hott, L. Miravet. Comparative effects of a novel Vitamin D Analogue MC-903 and 1,25-dihydroxyvitamin D3 on alkaline phosphatase activity, osteocalcin and DNA synthesis by human osteoblastic cells in culture. Bone. Volume 11, Issue 3, 1990, Pages 171-179

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标签归档：impurity

Impurity C of Calcitriol(Synonyms: PRE-骨化三醇PTAD加合物)

Impurity C of Calcitriol 相关产品

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Budesonide impurity C(Synonyms: 布地奈德杂质C)

Budesonide impurity C(Synonyms: 布地奈德杂质C)

Budesonide impurity C(Synonyms: 布地奈德杂质C)

Mesalamine impurity P

Mesalamine impurity P

Mesalamine impurity P

Ciprofibrate impurity A

Ciprofibrate impurity A

Ciprofibrate impurity A

Ciprofibrate impurity A-d4

Ciprofibrate impurity A-d4

Ciprofibrate impurity A-d4

HDAC-IN-7(Synonyms: Chidamide impurity)

HDAC-IN-7 相关产品

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Impurity F of Calcipotriol

Impurity F of Calcipotriol 相关产品

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HDAC-IN-7(Synonyms: Chidamide impurity)

HDAC-IN-7 相关产品

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Afatinib impurity 11

Afatinib impurity 11 相关产品

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Impurity B of Calcitriol(Synonyms: 1β,25-Dihydroxyvitamin-D3; 1-Epicalcitriol)

Impurity B of Calcitriol 相关产品

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MC 1046(Synonyms: Impurity A of Calcipotriol)

MC 1046 相关产品

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