PI3K/mTOR Inhibitor-3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PI3K/mTOR Inhibitor-3 

PI3K/mTOR Inhibitor-3 (化合物 12) 是一种咪唑并喹啉类化合物,是有效的 PI3KmTOR 双重抑制剂。PI3K/mTOR Inhibitor-3 具有抗癌活性。

PI3K/mTOR Inhibitor-3

PI3K/mTOR Inhibitor-3 Chemical Structure

CAS No. : 1363338-53-7

规格 是否有货
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250 mg   询价  
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生物活性

PI3K/mTOR Inhibitor-3 (compound 12), an imidazoline, is a potent PI3K and mTOR dual inhibitor. PI3K/mTOR Inhibitor-3 has anti-cancer activity[1].

IC50 & Target[1]

PI3K

 

mTOR

 

分子量

373.45

Formula

C22H23N5O

CAS 号

1363338-53-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhenhua Huang. Double inhibitors of PI3K and mTOR of imidazoline. CN102372711A.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SCD1 inhibitor-3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

SCD1 inhibitor-3 

SCD1 inhibitor-3 是一种安全、有效的具有口服活性的 SCD1 抑制剂。SCD1 inhibitor-3 可用于肥胖症、二型糖尿病、血脂异常等代谢性疾病,以及皮肤病、痤疮、癌症等的研究。

SCD1 inhibitor-3

SCD1 inhibitor-3 Chemical Structure

CAS No. : 1282606-48-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer[1].

IC50 & Target

SCD1[1]

体内研究
(In Vivo)

SCD1 inhibitor-3 (compound 17a) (5 mg/kg; p.o.; 4 hours) reduces the plasma C16:1/C16:0 triglycerides desaturation index by 54 %[1].
SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats[1]
Dosage: 5 mg/kg
Administration: P.o.; 4 hours
Result: Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %.
Animal Model: Lewis rats[1]
Dosage: 2~10 mg/kg
Administration: P.o.; 4 hours
Result: A dose-responsive reduction of plasma triglycerides desaturation index.

分子量

393.37

Formula

C19H16FN7O2

CAS 号

1282606-48-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sun S, et al. Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors. Bioorg Med Chem. 2015;23(3):455-465.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PI3K/mTOR Inhibitor-3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PI3K/mTOR Inhibitor-3 

PI3K/mTOR Inhibitor-3 (化合物 12) 是一种咪唑并喹啉类化合物,是有效的 PI3KmTOR 双重抑制剂。PI3K/mTOR Inhibitor-3 具有抗癌活性。

PI3K/mTOR Inhibitor-3

PI3K/mTOR Inhibitor-3 Chemical Structure

CAS No. : 1363338-53-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PI3K/mTOR Inhibitor-3 (compound 12), an imidazoline, is a potent PI3K and mTOR dual inhibitor. PI3K/mTOR Inhibitor-3 has anti-cancer activity[1].

IC50 & Target[1]

PI3K

 

mTOR

 

分子量

373.45

Formula

C22H23N5O

CAS 号

1363338-53-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhenhua Huang. Double inhibitors of PI3K and mTOR of imidazoline. CN102372711A.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PI3K/mTOR Inhibitor-3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PI3K/mTOR Inhibitor-3 

PI3K/mTOR Inhibitor-3 (化合物 12) 是一种咪唑并喹啉类化合物,是有效的 PI3KmTOR 双重抑制剂。PI3K/mTOR Inhibitor-3 具有抗癌活性。

PI3K/mTOR Inhibitor-3

PI3K/mTOR Inhibitor-3 Chemical Structure

CAS No. : 1363338-53-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PI3K/mTOR Inhibitor-3 (compound 12), an imidazoline, is a potent PI3K and mTOR dual inhibitor. PI3K/mTOR Inhibitor-3 has anti-cancer activity[1].

IC50 & Target[1]

PI3K

 

mTOR

 

分子量

373.45

Formula

C22H23N5O

CAS 号

1363338-53-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhenhua Huang. Double inhibitors of PI3K and mTOR of imidazoline. CN102372711A.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SCD1 inhibitor-3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

SCD1 inhibitor-3 

SCD1 inhibitor-3 是一种安全、有效的具有口服活性的 SCD1 抑制剂。SCD1 inhibitor-3 可用于肥胖症、二型糖尿病、血脂异常等代谢性疾病,以及皮肤病、痤疮、癌症等的研究。

SCD1 inhibitor-3

SCD1 inhibitor-3 Chemical Structure

CAS No. : 1282606-48-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer[1].

IC50 & Target

SCD1[1]

体内研究
(In Vivo)

SCD1 inhibitor-3 (compound 17a) (5 mg/kg; p.o.; 4 hours) reduces the plasma C16:1/C16:0 triglycerides desaturation index by 54 %[1].
SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats[1]
Dosage: 5 mg/kg
Administration: P.o.; 4 hours
Result: Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %.
Animal Model: Lewis rats[1]
Dosage: 2~10 mg/kg
Administration: P.o.; 4 hours
Result: A dose-responsive reduction of plasma triglycerides desaturation index.

分子量

393.37

Formula

C19H16FN7O2

CAS 号

1282606-48-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sun S, et al. Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors. Bioorg Med Chem. 2015;23(3):455-465.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SCD1 inhibitor-3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

SCD1 inhibitor-3 

SCD1 inhibitor-3 是一种安全、有效的具有口服活性的 SCD1 抑制剂。SCD1 inhibitor-3 可用于肥胖症、二型糖尿病、血脂异常等代谢性疾病,以及皮肤病、痤疮、癌症等的研究。

SCD1 inhibitor-3

SCD1 inhibitor-3 Chemical Structure

CAS No. : 1282606-48-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer[1].

IC50 & Target

SCD1[1]

体内研究
(In Vivo)

SCD1 inhibitor-3 (compound 17a) (5 mg/kg; p.o.; 4 hours) reduces the plasma C16:1/C16:0 triglycerides desaturation index by 54 %[1].
SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats[1]
Dosage: 5 mg/kg
Administration: P.o.; 4 hours
Result: Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %.
Animal Model: Lewis rats[1]
Dosage: 2~10 mg/kg
Administration: P.o.; 4 hours
Result: A dose-responsive reduction of plasma triglycerides desaturation index.

分子量

393.37

Formula

C19H16FN7O2

CAS 号

1282606-48-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sun S, et al. Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors. Bioorg Med Chem. 2015;23(3):455-465.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

LIN28 inhibitor LI71 enantiomer

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

LIN28 inhibitor LI71 enantiomer  纯度: 99.83%

LIN28 inhibitor LI71 enantiomer 是 LIN28 inhibitor LI71 的 less active 对映异构体。LIN28 inhibitor LI71 是一种有效且可渗透细胞的 LIN28 抑制剂,其消除 LIN28 介导的低聚脲化的 IC50 为 7 uM。

LIN28 inhibitor LI71 enantiomer

LIN28 inhibitor LI71 enantiomer Chemical Structure

CAS No. : 956189-58-5

规格 价格 是否有货 数量
5 mg ¥4200 In-stock
10 mg ¥7000 In-stock
50 mg ¥20000 In-stock
100 mg ¥30000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

LIN28 inhibitor LI71 enantiomer 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library

生物活性

LIN28 inhibitor LI71 enantiomer is the enantiomer of LIN28 inhibitor LI71 with less active. LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM[1].

IC50 & Target

LIN280[1]

分子量

335.40

Formula

C21H21NO3

CAS 号

956189-58-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 2.7 mg/mL (8.05 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9815 mL 14.9076 mL 29.8151 mL
5 mM 0.5963 mL 2.9815 mL 5.9630 mL
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018;23(10):3091-3101.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

LIN28 inhibitor LI71 enantiomer

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

LIN28 inhibitor LI71 enantiomer  纯度: 99.83%

LIN28 inhibitor LI71 enantiomer 是 LIN28 inhibitor LI71 的 less active 对映异构体。LIN28 inhibitor LI71 是一种有效且可渗透细胞的 LIN28 抑制剂,其消除 LIN28 介导的低聚脲化的 IC50 为 7 uM。

LIN28 inhibitor LI71 enantiomer

LIN28 inhibitor LI71 enantiomer Chemical Structure

CAS No. : 956189-58-5

规格 价格 是否有货 数量
5 mg ¥4200 In-stock
10 mg ¥7000 In-stock
50 mg ¥20000 In-stock
100 mg ¥30000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

LIN28 inhibitor LI71 enantiomer 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library

生物活性

LIN28 inhibitor LI71 enantiomer is the enantiomer of LIN28 inhibitor LI71 with less active. LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM[1].

IC50 & Target

LIN280[1]

分子量

335.40

Formula

C21H21NO3

CAS 号

956189-58-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 2.7 mg/mL (8.05 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9815 mL 14.9076 mL 29.8151 mL
5 mM 0.5963 mL 2.9815 mL 5.9630 mL
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018;23(10):3091-3101.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

LIN28 inhibitor LI71 enantiomer

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

LIN28 inhibitor LI71 enantiomer  纯度: 99.83%

LIN28 inhibitor LI71 enantiomer 是 LIN28 inhibitor LI71 的 less active 对映异构体。LIN28 inhibitor LI71 是一种有效且可渗透细胞的 LIN28 抑制剂,其消除 LIN28 介导的低聚脲化的 IC50 为 7 uM。

LIN28 inhibitor LI71 enantiomer

LIN28 inhibitor LI71 enantiomer Chemical Structure

CAS No. : 956189-58-5

规格 价格 是否有货 数量
5 mg ¥4200 In-stock
10 mg ¥7000 In-stock
50 mg ¥20000 In-stock
100 mg ¥30000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

LIN28 inhibitor LI71 enantiomer 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library

生物活性

LIN28 inhibitor LI71 enantiomer is the enantiomer of LIN28 inhibitor LI71 with less active. LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM[1].

IC50 & Target

LIN280[1]

分子量

335.40

Formula

C21H21NO3

CAS 号

956189-58-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 2.7 mg/mL (8.05 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9815 mL 14.9076 mL 29.8151 mL
5 mM 0.5963 mL 2.9815 mL 5.9630 mL
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018;23(10):3091-3101.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

CAIX Inhibitor S4

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CAIX Inhibitor S4 

CAIX Inhibitor S4 是一种有效和选择性的碳酸酐酶 IX/XII (CA IX/XII) 的抑制剂,Ki 值分别为 7 nM 和 2 nM。CAIX Inhibitor S4 还抑制 CA IICA I (Ki=546 nM, 5600 nM)。CAIX Inhibitor S4 可以抑制原位 MDA-MB-231 小鼠模型中肺转移的数量,而不影响原发肿瘤的生长。

CAIX Inhibitor S4

CAIX Inhibitor S4 Chemical Structure

CAS No. : 1330061-67-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth[1].

IC50 & Target

Ki: 2 nM (CA XII), 7 nM (CA IX), 546 nM (CA II), 5600 nM (CA I)[1]

体外研究
(In Vitro)

CAIX Inhibitor S4 (1-100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner[1].
CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration- dependent manner[1].
CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HCT116 and HT29 cells
Concentration: 1, 10, 100 μM
Incubation Time: 24 hours
Result: Inhibited the cell proliferation of MDA-MB-231, HCT116 and HT29 cells, with IC50s of 481 μM, >1000 μM, and 20 μM, respectively.

体内研究
(In Vivo)

CAIX Inhibitor S4 (10 mg/kg; i.p. for 14 days) inhibits metastatic tumor burden in MDA-MB-231 model while having no effect on primary tumor growth or mouse condition[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nu/nu CBA mice (10-12 weeks) were injected with eGFP-MDA-MB-231 cells[1]
Dosage: 10 mg/kg
Administration: I.p. daily on a “5 days on, 2 days off” dosing regimen for 14 days
Result: Significantly reduced the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors.
The average body weights between vehicle and S4 treated mice were similar throughout the experiments.

分子量

335.38

Formula

C15H17N3O4S

CAS 号

1330061-67-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Gieling RG, et, al. Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J Med Chem. 2012 Jun 14;55(11):5591-600.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

CAIX Inhibitor S4

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CAIX Inhibitor S4 

CAIX Inhibitor S4 是一种有效和选择性的碳酸酐酶 IX/XII (CA IX/XII) 的抑制剂,Ki 值分别为 7 nM 和 2 nM。CAIX Inhibitor S4 还抑制 CA IICA I (Ki=546 nM, 5600 nM)。CAIX Inhibitor S4 可以抑制原位 MDA-MB-231 小鼠模型中肺转移的数量,而不影响原发肿瘤的生长。

CAIX Inhibitor S4

CAIX Inhibitor S4 Chemical Structure

CAS No. : 1330061-67-0

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100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth[1].

IC50 & Target

Ki: 2 nM (CA XII), 7 nM (CA IX), 546 nM (CA II), 5600 nM (CA I)[1]

体外研究
(In Vitro)

CAIX Inhibitor S4 (1-100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner[1].
CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration- dependent manner[1].
CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HCT116 and HT29 cells
Concentration: 1, 10, 100 μM
Incubation Time: 24 hours
Result: Inhibited the cell proliferation of MDA-MB-231, HCT116 and HT29 cells, with IC50s of 481 μM, >1000 μM, and 20 μM, respectively.

体内研究
(In Vivo)

CAIX Inhibitor S4 (10 mg/kg; i.p. for 14 days) inhibits metastatic tumor burden in MDA-MB-231 model while having no effect on primary tumor growth or mouse condition[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nu/nu CBA mice (10-12 weeks) were injected with eGFP-MDA-MB-231 cells[1]
Dosage: 10 mg/kg
Administration: I.p. daily on a “5 days on, 2 days off” dosing regimen for 14 days
Result: Significantly reduced the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors.
The average body weights between vehicle and S4 treated mice were similar throughout the experiments.

分子量

335.38

Formula

C15H17N3O4S

CAS 号

1330061-67-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Gieling RG, et, al. Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J Med Chem. 2012 Jun 14;55(11):5591-600.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

CAIX Inhibitor S4

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CAIX Inhibitor S4 

CAIX Inhibitor S4 是一种有效和选择性的碳酸酐酶 IX/XII (CA IX/XII) 的抑制剂,Ki 值分别为 7 nM 和 2 nM。CAIX Inhibitor S4 还抑制 CA IICA I (Ki=546 nM, 5600 nM)。CAIX Inhibitor S4 可以抑制原位 MDA-MB-231 小鼠模型中肺转移的数量,而不影响原发肿瘤的生长。

CAIX Inhibitor S4

CAIX Inhibitor S4 Chemical Structure

CAS No. : 1330061-67-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth[1].

IC50 & Target

Ki: 2 nM (CA XII), 7 nM (CA IX), 546 nM (CA II), 5600 nM (CA I)[1]

体外研究
(In Vitro)

CAIX Inhibitor S4 (1-100 μM; 24 h) inhibits the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner[1].
CAIX Inhibitor S4 (3.3-33 μM; 24 h) inhibits the eGFP-MDA-MB-231 cell migration in anoxia in a concentration- dependent manner[1].
CAIX Inhibitor S4 (33 μM; 15-60 min) delays the cell spreading of MDA-MB-231 cells in anoxia but essentially not in normoxia[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HCT116 and HT29 cells
Concentration: 1, 10, 100 μM
Incubation Time: 24 hours
Result: Inhibited the cell proliferation of MDA-MB-231, HCT116 and HT29 cells, with IC50s of 481 μM, >1000 μM, and 20 μM, respectively.

体内研究
(In Vivo)

CAIX Inhibitor S4 (10 mg/kg; i.p. for 14 days) inhibits metastatic tumor burden in MDA-MB-231 model while having no effect on primary tumor growth or mouse condition[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nu/nu CBA mice (10-12 weeks) were injected with eGFP-MDA-MB-231 cells[1]
Dosage: 10 mg/kg
Administration: I.p. daily on a “5 days on, 2 days off” dosing regimen for 14 days
Result: Significantly reduced the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors.
The average body weights between vehicle and S4 treated mice were similar throughout the experiments.

分子量

335.38

Formula

C15H17N3O4S

CAS 号

1330061-67-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Gieling RG, et, al. Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J Med Chem. 2012 Jun 14;55(11):5591-600.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

WT IDH1 Inhibitor 2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

WT IDH1 Inhibitor 2 

WT IDH1 Inhibitor 2 (Compound 3) 是野生型异柠檬酸脱氢酶1 (WT IDH1) 抑制剂,IC50 值为120 nM。WT IDH1 Inhibitor 2 作为突变体 R132H IDH1 抑制剂,是 GSK321 的异构体,具有野生型交叉反应性。

WT IDH1 Inhibitor 2

WT IDH1 Inhibitor 2 Chemical Structure

CAS No. : 1816272-19-1

规格 价格 是否有货
5 mg ¥9200 询问价格 & 货期
10 mg ¥14500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].

IC50 & Target

IC50: 120 nM (WT IDH1)[1]

体外研究
(In Vitro)

WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

501.55

Formula

C28H28FN5O3

CAS 号

1816272-19-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

WT IDH1 Inhibitor 2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

WT IDH1 Inhibitor 2 

WT IDH1 Inhibitor 2 (Compound 3) 是野生型异柠檬酸脱氢酶1 (WT IDH1) 抑制剂,IC50 值为120 nM。WT IDH1 Inhibitor 2 作为突变体 R132H IDH1 抑制剂,是 GSK321 的异构体,具有野生型交叉反应性。

WT IDH1 Inhibitor 2

WT IDH1 Inhibitor 2 Chemical Structure

CAS No. : 1816272-19-1

规格 价格 是否有货
5 mg ¥9200 询问价格 & 货期
10 mg ¥14500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].

IC50 & Target

IC50: 120 nM (WT IDH1)[1]

体外研究
(In Vitro)

WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

501.55

Formula

C28H28FN5O3

CAS 号

1816272-19-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

WT IDH1 Inhibitor 2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

WT IDH1 Inhibitor 2 

WT IDH1 Inhibitor 2 (Compound 3) 是野生型异柠檬酸脱氢酶1 (WT IDH1) 抑制剂,IC50 值为120 nM。WT IDH1 Inhibitor 2 作为突变体 R132H IDH1 抑制剂,是 GSK321 的异构体,具有野生型交叉反应性。

WT IDH1 Inhibitor 2

WT IDH1 Inhibitor 2 Chemical Structure

CAS No. : 1816272-19-1

规格 价格 是否有货
5 mg ¥9200 询问价格 & 货期
10 mg ¥14500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].

IC50 & Target

IC50: 120 nM (WT IDH1)[1]

体外研究
(In Vitro)

WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

501.55

Formula

C28H28FN5O3

CAS 号

1816272-19-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

FGFR1 inhibitor-2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

FGFR1 inhibitor-2 

FGFR1 inhibitor-2 是一个 FGFR1 抑制剂(IC50 为 4.55 μM 在 MDA-MB-231细胞中)。FGFR1 inhibitor-2 可用于转移性三阴性乳腺癌的研究。

FGFR1 inhibitor-2

FGFR1 inhibitor-2 Chemical Structure

CAS No. : 2410612-08-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer[1].

IC50 & Target[1]

FGFR1

 

体外研究
(In Vitro)

FGFR1 inhibitor-2 (3 and 6 μM; 48 hours; MDA-MB-231) reduces the expression of FGFR1[1].
FGFR1 inhibitor-2 (0~5 μM; MDA-MB-231) increases the apoptotic index by 10.6-fold at 5 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 3 and 6 μM
Incubation Time: 48 hours
Result: Reduced the expression of FGFR1.

分子量

507.45

Formula

C25H22F5N3O3

CAS 号

2410612-08-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ashraf-Uz-Zaman M, et al. Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer. Eur J Med Chem. 2021;209:112866.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

FGFR1 inhibitor-2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

FGFR1 inhibitor-2 

FGFR1 inhibitor-2 是一个 FGFR1 抑制剂(IC50 为 4.55 μM 在 MDA-MB-231细胞中)。FGFR1 inhibitor-2 可用于转移性三阴性乳腺癌的研究。

FGFR1 inhibitor-2

FGFR1 inhibitor-2 Chemical Structure

CAS No. : 2410612-08-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer[1].

IC50 & Target[1]

FGFR1

 

体外研究
(In Vitro)

FGFR1 inhibitor-2 (3 and 6 μM; 48 hours; MDA-MB-231) reduces the expression of FGFR1[1].
FGFR1 inhibitor-2 (0~5 μM; MDA-MB-231) increases the apoptotic index by 10.6-fold at 5 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 3 and 6 μM
Incubation Time: 48 hours
Result: Reduced the expression of FGFR1.

分子量

507.45

Formula

C25H22F5N3O3

CAS 号

2410612-08-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ashraf-Uz-Zaman M, et al. Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer. Eur J Med Chem. 2021;209:112866.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

FGFR1 inhibitor-2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

FGFR1 inhibitor-2 

FGFR1 inhibitor-2 是一个 FGFR1 抑制剂(IC50 为 4.55 μM 在 MDA-MB-231细胞中)。FGFR1 inhibitor-2 可用于转移性三阴性乳腺癌的研究。

FGFR1 inhibitor-2

FGFR1 inhibitor-2 Chemical Structure

CAS No. : 2410612-08-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer[1].

IC50 & Target[1]

FGFR1

 

体外研究
(In Vitro)

FGFR1 inhibitor-2 (3 and 6 μM; 48 hours; MDA-MB-231) reduces the expression of FGFR1[1].
FGFR1 inhibitor-2 (0~5 μM; MDA-MB-231) increases the apoptotic index by 10.6-fold at 5 μM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 3 and 6 μM
Incubation Time: 48 hours
Result: Reduced the expression of FGFR1.

分子量

507.45

Formula

C25H22F5N3O3

CAS 号

2410612-08-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ashraf-Uz-Zaman M, et al. Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer. Eur J Med Chem. 2021;209:112866.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

TCS PrP Inhibitor 13

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

TCS PrP Inhibitor 13 

TCS PrP Inhibitor 13作为一种抗朊病毒化合物,是一种细胞朊病毒蛋白(PrPC)抑制剂。TCS PrP Inhibitor 13作为朊病毒蛋白(PrP-res)积累抑制剂,在ScN2a和F3细胞株中均显示IC50值为3 nM。TCS PrP Inhibitor 13 诱导神经鞘瘤细胞调亡

TCS PrP Inhibitor 13

TCS PrP Inhibitor 13 Chemical Structure

CAS No. : 34320-83-7

规格 价格 是否有货 数量
5 mg ¥1000 In-stock
10 mg ¥1600 In-stock
25 mg ¥3500 In-stock
50 mg ¥5500 In-stock
100 mg ¥9500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

TCS PrP Inhibitor 13 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Apoptosis Compound Library
  • Anti-Cancer Compound Library
  • Targeted Diversity Library

生物活性

TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1].

IC50 & Target

IC50: 3 nM (PrPC in ScN2a and F3 cells)[1]

体外研究
(In Vitro)

TCS PrP Inhibitor 13 (0~500 μM; Schwannoma cells) significantly reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrPC and significantly increases expression of cleaved caspase-3. TCS PrP Inhibitor 13 (Schwannoma cells) significantly reduces the number of proliferating, Ki67-positive cells and total cell number[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

281.27

Formula

C15H11N3O3

CAS 号

34320-83-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (355.53 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5553 mL 17.7765 mL 35.5530 mL
5 mM 0.7111 mL 3.5553 mL 7.1106 mL
10 mM 0.3555 mL 1.7777 mL 3.5553 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.89 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.89 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Kimata A, et al. New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation [published correction appears in J Med Chem. 2008 Mar 13;51(5):1503]. J Med Chem. 2007;50(21):5053-5056.

    [2]. Provenzano L, et al. Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 2017;36(44):6132-6142.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

TCS PrP Inhibitor 13

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

TCS PrP Inhibitor 13 

TCS PrP Inhibitor 13作为一种抗朊病毒化合物,是一种细胞朊病毒蛋白(PrPC)抑制剂。TCS PrP Inhibitor 13作为朊病毒蛋白(PrP-res)积累抑制剂,在ScN2a和F3细胞株中均显示IC50值为3 nM。TCS PrP Inhibitor 13 诱导神经鞘瘤细胞调亡

TCS PrP Inhibitor 13

TCS PrP Inhibitor 13 Chemical Structure

CAS No. : 34320-83-7

规格 价格 是否有货 数量
5 mg ¥1000 In-stock
10 mg ¥1600 In-stock
25 mg ¥3500 In-stock
50 mg ¥5500 In-stock
100 mg ¥9500 In-stock
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500 mg   询价  

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TCS PrP Inhibitor 13 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Apoptosis Compound Library
  • Anti-Cancer Compound Library
  • Targeted Diversity Library

生物活性

TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1].

IC50 & Target

IC50: 3 nM (PrPC in ScN2a and F3 cells)[1]

体外研究
(In Vitro)

TCS PrP Inhibitor 13 (0~500 μM; Schwannoma cells) significantly reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrPC and significantly increases expression of cleaved caspase-3. TCS PrP Inhibitor 13 (Schwannoma cells) significantly reduces the number of proliferating, Ki67-positive cells and total cell number[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

281.27

Formula

C15H11N3O3

CAS 号

34320-83-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (355.53 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5553 mL 17.7765 mL 35.5530 mL
5 mM 0.7111 mL 3.5553 mL 7.1106 mL
10 mM 0.3555 mL 1.7777 mL 3.5553 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.89 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.89 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Kimata A, et al. New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation [published correction appears in J Med Chem. 2008 Mar 13;51(5):1503]. J Med Chem. 2007;50(21):5053-5056.

    [2]. Provenzano L, et al. Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 2017;36(44):6132-6142.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务