Precisa普利赛斯精密天平LS10200D

发表于2024年1月4日由上海金畔生物科技有限公司

品牌普利赛斯|Precisa

型号 LS10200D

可选配件及服务

Precisa普利赛斯精密天平LS10200D

Precisa普利赛斯专用打印机

¥2000.00

请询价

商品详情

产品介绍：
321系列电子天平， Precisa中高端电子天平，精度高，反应快，稳定性好，性价比高，满足您预算的同时，提供高质量的称量结果。

主要特点：
全铝合金外壳铸造，防震、防尘、防辐射性能良好
内置时钟，支持3Q认证
全自动内校功能，可以根据温度时间的变化进行校准（部分型号选配）
可选配密封性良好的圆柱形风罩
实验室称重分析、物质称重分析等。

型号	产品描述	价格
LS120ASCS	LS120A分析天平（称量范围120g,读数精度0.1mg）SCS智能内校功能	13000
LS220ASCS	LS220A分析天平（称量范围220g,读数精度0.1mg）SCS智能内校功能	14200
LS320MSCS	LS320M精密天平（称量范围320g,读数精度1mg）SCS智能内校功能	12800
LS620MSCS	LS620M精密天平（称量范围620g,读数精度1mg）SCS智能内校功能	14000
LS1220MSCS	LS1220M精密天平（称量范围1220g,读数精度1mg）SCS智能内校功能	15000
LS1200CSCS	LS1220C精密天平（称量范围1220g,读数精度0.01g）SCS智能内校功能	12500
LS3200CSCS	LS3200C精密天平（称量范围3200g,读数精度0.01g）SCS智能内校功能	13500
LS4200CSCS	LS4200C精密天平（称量范围4200g,读数精度0.01g）SCS智能内校功能	18850
LS6200CSCS	LS6200C精密天平（称量范围6200g,读数精度0.01g）SCS智能内校功能	14500
LS3200DSCS	LS3200D精密天平（称量范围3200g,读数精度0.1g）SCS智能内校功能	12200
LS6200DSCS	LS6200D精密天平（称量范围6200g,读数精度0.1g）SCS智能内校功能	13300
LS10200DSCS	LS10200D精密天平（称量范围10200g,读数精度0.1g）SCS智能内校功能	14800
LS120A	LS120A分析天平（称量范围120g,读数精度0.1mg）	11600
LS220A	LS220A分析天平（称量范围220g,读数精度0.1mg）	12600
LS320M	LS320M精密天平（称量范围320g,读数精度1mg）	10800
LS620M	LS620M精密天平（称量范围620g,读数精度1mg）	11800
LS1220M	LS1220M精密天平（称量范围1220g,读数精度1mg）	12800
LS1200C	LS1220C精密天平（称量范围1220g,读数精度0.01g）	10800
LS3200C	LS3200C精密天平（称量范围3200g,读数精度0.01g）	11000
LS6200C	LS6200C精密天平（称量范围6200g,读数精度0.01g）	12500
LS3200D	LS3200D精密天平（称量范围3200g,读数精度0.1g）	10800
LS6200D	LS6200D精密天平（称量范围6200g,读数精度0.1g）	11200
LS10200D	LS10200D精密天平（称量范围10200g,读数精度0.1g）	12000

Precisa普利赛斯精密天平LS6200D

发表于2024年1月4日由上海金畔生物科技有限公司

Precisa普利赛斯精密天平LS6200D

品牌普利赛斯|Precisa

型号 LS6200D

可选配件及服务

Precisa普利赛斯精密天平LS6200D

Precisa普利赛斯专用打印机

¥2000.00

请询价

商品详情

产品介绍：
321系列电子天平， Precisa中高端电子天平，精度高，反应快，稳定性好，性价比高，满足您预算的同时，提供高质量的称量结果。

型号	产品描述	价格
LS120ASCS	LS120A分析天平（称量范围120g,读数精度0.1mg）SCS智能内校功能	13000
LS220ASCS	LS220A分析天平（称量范围220g,读数精度0.1mg）SCS智能内校功能	14200
LS320MSCS	LS320M精密天平（称量范围320g,读数精度1mg）SCS智能内校功能	12800
LS620MSCS	LS620M精密天平（称量范围620g,读数精度1mg）SCS智能内校功能	14000
LS1220MSCS	LS1220M精密天平（称量范围1220g,读数精度1mg）SCS智能内校功能	15000
LS1200CSCS	LS1220C精密天平（称量范围1220g,读数精度0.01g）SCS智能内校功能	12500
LS3200CSCS	LS3200C精密天平（称量范围3200g,读数精度0.01g）SCS智能内校功能	13500
LS4200CSCS	LS4200C精密天平（称量范围4200g,读数精度0.01g）SCS智能内校功能	18850
LS6200CSCS	LS6200C精密天平（称量范围6200g,读数精度0.01g）SCS智能内校功能	14500
LS3200DSCS	LS3200D精密天平（称量范围3200g,读数精度0.1g）SCS智能内校功能	12200
LS6200DSCS	LS6200D精密天平（称量范围6200g,读数精度0.1g）SCS智能内校功能	13300
LS10200DSCS	LS10200D精密天平（称量范围10200g,读数精度0.1g）SCS智能内校功能	14800
LS120A	LS120A分析天平（称量范围120g,读数精度0.1mg）	11600
LS220A	LS220A分析天平（称量范围220g,读数精度0.1mg）	12600
LS320M	LS320M精密天平（称量范围320g,读数精度1mg）	10800
LS620M	LS620M精密天平（称量范围620g,读数精度1mg）	11800
LS1220M	LS1220M精密天平（称量范围1220g,读数精度1mg）	12800
LS1200C	LS1220C精密天平（称量范围1220g,读数精度0.01g）	10800
LS3200C	LS3200C精密天平（称量范围3200g,读数精度0.01g）	11000
LS6200C	LS6200C精密天平（称量范围6200g,读数精度0.01g）	12500
LS3200D	LS3200D精密天平（称量范围3200g,读数精度0.1g）	10800
LS6200D	LS6200D精密天平（称量范围6200g,读数精度0.1g）	11200
LS10200D	LS10200D精密天平（称量范围10200g,读数精度0.1g）	12000

Precisa普利赛斯精密天平LS3200D

发表于2024年1月4日由上海金畔生物科技有限公司

Precisa普利赛斯精密天平LS3200D

品牌普利赛斯|Precisa

型号 LS3200D

可选配件及服务

Precisa普利赛斯精密天平LS3200D

Precisa普利赛斯专用打印机

¥2000.00

请询价

商品详情

产品介绍：
321系列电子天平， Precisa中高端电子天平，精度高，反应快，稳定性好，性价比高，满足您预算的同时，提供高质量的称量结果。

型号	产品描述	价格
LS120ASCS	LS120A分析天平（称量范围120g,读数精度0.1mg）SCS智能内校功能	13000
LS220ASCS	LS220A分析天平（称量范围220g,读数精度0.1mg）SCS智能内校功能	14200
LS320MSCS	LS320M精密天平（称量范围320g,读数精度1mg）SCS智能内校功能	12800
LS620MSCS	LS620M精密天平（称量范围620g,读数精度1mg）SCS智能内校功能	14000
LS1220MSCS	LS1220M精密天平（称量范围1220g,读数精度1mg）SCS智能内校功能	15000
LS1200CSCS	LS1220C精密天平（称量范围1220g,读数精度0.01g）SCS智能内校功能	12500
LS3200CSCS	LS3200C精密天平（称量范围3200g,读数精度0.01g）SCS智能内校功能	13500
LS4200CSCS	LS4200C精密天平（称量范围4200g,读数精度0.01g）SCS智能内校功能	18850
LS6200CSCS	LS6200C精密天平（称量范围6200g,读数精度0.01g）SCS智能内校功能	14500
LS3200DSCS	LS3200D精密天平（称量范围3200g,读数精度0.1g）SCS智能内校功能	12200
LS6200DSCS	LS6200D精密天平（称量范围6200g,读数精度0.1g）SCS智能内校功能	13300
LS10200DSCS	LS10200D精密天平（称量范围10200g,读数精度0.1g）SCS智能内校功能	14800
LS120A	LS120A分析天平（称量范围120g,读数精度0.1mg）	11600
LS220A	LS220A分析天平（称量范围220g,读数精度0.1mg）	12600
LS320M	LS320M精密天平（称量范围320g,读数精度1mg）	10800
LS620M	LS620M精密天平（称量范围620g,读数精度1mg）	11800
LS1220M	LS1220M精密天平（称量范围1220g,读数精度1mg）	12800
LS1200C	LS1220C精密天平（称量范围1220g,读数精度0.01g）	10800
LS3200C	LS3200C精密天平（称量范围3200g,读数精度0.01g）	11000
LS6200C	LS6200C精密天平（称量范围6200g,读数精度0.01g）	12500
LS3200D	LS3200D精密天平（称量范围3200g,读数精度0.1g）	10800
LS6200D	LS6200D精密天平（称量范围6200g,读数精度0.1g）	11200
LS10200D	LS10200D精密天平（称量范围10200g,读数精度0.1g）	12000

LSD1-IN-21

发表于2023年12月22日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

LSD1-IN-21

LSD1-IN-21 (化合物 5a) 是一种有效的可透过血脑屏障的 LSD1 (赖氨酸特异性去甲基化酶 -1) 抑制剂，其 IC₅₀ 为 0.956 µM。LSD1-IN-21 显著降低促炎细胞因子 TNF-α。LSD1-IN-21 具有良好的抗癌和抗炎活性。

LSD1-IN-21 Chemical Structure

规格		是否有货
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250 mg		询价
500 mg		询价

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生物活性

LSD1-IN-21 (compound 5a) is a potent and BBB-penetrated LSD1 (Lysine specific demethylase-1) inhibitor, with an IC₅₀ of 0.956 µM. LSD1-IN-21 significantly reduces the pro-inflammatory cytokine TNF-α. LSD1-IN-21 shows good anticancer and anti-inflammatory activity^[1].

IC₅₀ & Target

TNF-α

体外研究
(In Vitro)

LSD1-IN-21 (compound 5a) shows potent anti-cancer activity with GI₅₀ values of 0.414 and 0.417 µM against HOP-62 and OVCAR-4 cell lines, respectively^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

447.55

Formula

C₂₄H₂₅N₅O₂S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Tasneem S, et al. Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents. Bioorg Chem. 2022 May 21;126:105885.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

GSK-LSD1-d4 dihydrochloride

发表于2023年12月20日由上海金畔生物科技有限公司

GSK-LSD1-d4 dihydrochloride

GSK-LSD1-d4 dihydrochloride 是 GSK-LSD1 dihydrochloride 的氘代物。GSK-LSD1 dihydrochloride 是有效，选择性，不可逆的赖氨酸特异性脱甲基酶 (LSD1) 抑制剂，IC₅₀ 值为 16 nM。

GSK-LSD1-d4 dihydrochloride Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	GSK-LSD1-d4 dihydrochloride is the deuterium labeled GSK-LSD1 dihydrochloride. GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 16 nM.
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	293.27
Formula	C₁₄H₁₇D₄ClN₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Purich D. The Inhibitor Index A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads. ISBN 9781138739215 [3]. Wang Z, et al. Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochim Biophys Acta. 2017 Aug 8;1864(12):2428-2437.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

GSK-LSD1-d4 dihydrochloride

发表于2023年12月20日由上海金畔生物科技有限公司

GSK-LSD1-d4 dihydrochloride

GSK-LSD1-d4 dihydrochloride Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	GSK-LSD1-d4 dihydrochloride is the deuterium labeled GSK-LSD1 dihydrochloride. GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 16 nM.
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	293.27
Formula	C₁₄H₁₇D₄ClN₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Purich D. The Inhibitor Index A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads. ISBN 9781138739215 [3]. Wang Z, et al. Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochim Biophys Acta. 2017 Aug 8;1864(12):2428-2437.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

GSK-LSD1-d4 dihydrochloride

发表于2023年12月20日由上海金畔生物科技有限公司

GSK-LSD1-d4 dihydrochloride

GSK-LSD1-d4 dihydrochloride Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性	GSK-LSD1-d4 dihydrochloride is the deuterium labeled GSK-LSD1 dihydrochloride. GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC₅₀ of 16 nM.
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	293.27
Formula	C₁₄H₁₇D₄ClN₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Purich D. The Inhibitor Index A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads. ISBN 9781138739215 [3]. Wang Z, et al. Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochim Biophys Acta. 2017 Aug 8;1864(12):2428-2437.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

LSD1/ER-IN-1

发表于2023年12月8日由上海金畔生物科技有限公司

LSD1/ER-IN-1

LSD1/ER-IN-1 (compound 11g) 是一种有效的 ER 和 LSD1 抑制剂，其IC₅₀ 为 1.55 μM (LSD1)。LSD1/ER-IN-1 对 ERα 蛋白有高亲和力选择性，α/β 比为7.11。LSD1/ER-IN-1 对 MCF-7 乳腺癌细胞具有良好的抗增殖活性，其 IC₅₀ 为8.79 μM。

LSD1/ER-IN-1 Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

LSD1/ER-IN-1 (compound 11g) is a potent ER and LSD1 inhibitor, with an IC₅₀ of 1.55 μM (LSD1). LSD1/ER-IN-1 has high affinity selectivity for ERα protein, with α/β ratio of 7.11. LSD1/ER-IN-1 shows good antiproliferative activity against MCF-7 breast cancer cells, with an IC₅₀ of 8.79 μM^[1].

IC₅₀ & Target

ERα

ERβ

体外研究
(In Vitro)

LSD1/ER-IN-1 (compound 11g) (0-30 μM, 24 h) induces apoptosis in MCF-7 cells in a dose-dependent manner^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

455.46

Formula

C₂₃H₁₈FNO₆S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. He M, et al. Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer. Eur J Med Chem. 2020 Jun 1;195:112281.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

LSD1-IN-12

发表于2023年12月8日由上海金畔生物科技有限公司

LSD1-IN-12

LSD1-IN-12 (compound 2) 是一种有效的 LSD1 抑制剂，其 K_i 值分别为 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), 和 3.5 μM (MAO-B)。

LSD1-IN-12 Chemical Structure

CAS No. : 1228143-76-7

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

LSD1-IN-12 (compound 2) is a potent LSD1 inhibitor, with K_i values of 1.1 μM (LSD1), 61 μM (LSD2), 2.3 μM (MAO-A), and 3.5 μM (MAO-B), respectively^[1].

IC₅₀ & Target

MAO-A

2.3 μM (Ki)

MAO-B

3.5 μM (Ki)

分子量

252.31

Formula

C₁₆H₁₆N₂O

CAS 号

1228143-76-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Li C, et al. Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem. 2022 Mar 10;65(5):4335-4349.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

LSD1-IN-13

发表于2023年12月8日由上海金畔生物科技有限公司

LSD1-IN-13

LSD1-IN-13 (compound 7e) 是一种口服有效的 LSD1 抑制剂，其 IC₅₀ 值为 24.43 nM。LSD1-IN-13 可激活 CD86 表达，其 EC₅₀ 值为 470 nM。LSD1-IN-13 诱导 AML (急性髓系白血病)细胞系分化。

LSD1-IN-13 Chemical Structure

CAS No. : 2170212-33-4

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生物活性	LSD1-IN-13 (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC₅₀ of 24.43 nM. LSD1-IN-13 can activate CD86 expression, with an EC₅₀ of 470 nM. LSD1-IN-13 induces differentiation of AML (acute myeloid leukemia) cell lines^[1].
IC₅₀ & Target	IC₅₀: 24.43 ± 1.08 nM (LSD1), 5.00 ± 0.28 μM (LSD2), >100 μM (MAO-A), >100 μM (MAO-B)^[1]
体外研究 (In Vitro)	LSD1-IN-13 (compound 7e) shows good selectivity over LSD2 (205-fold) and MAOs (>4000-fold)^[1]. LSD1-IN-13 shows potent and selective antiproliferative activity in MV-4-11, with an IC₅₀ of 1.36 μM^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	LSD1-IN-13 (compound 7e) (MV-4-11 xenograft mice, 0-20 mg/kg, Orally, daily for 15 days) suppresses tumor growth significantly in a dose-dependent manner^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	411.56
Formula	C₂₃H₂₉N₃O₂S
CAS 号	2170212-33-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Li C, et al. Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem. 2022 Mar 10;65(5):4335-4349.

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LSD1-IN-13 hydrochloride

发表于2023年12月8日由上海金畔生物科技有限公司

LSD1-IN-13 hydrochloride

LSD1-IN-13 hydrochloride (compound 7e) 是一种口服有效的 LSD1 抑制剂，其 IC₅₀ 值为 24.43 nM。LSD1-IN-13 hydrochloride 可激活 CD86 表达，其 EC₅₀ 值为 470 nM。LSD1-IN-13 hydrochloride 诱导 AML (急性髓系白血病)细胞系分化。

LSD1-IN-13 hydrochloride Chemical Structure

CAS No. : 2170347-90-5

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生物活性	LSD1-IN-13 hydrochloride (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC₅₀ of 24.43 nM. LSD1-IN-13 hydrochloride can activate CD86 expression, with an EC₅₀ of 470 nM. LSD1-IN-13 hydrochloride induces differentiation of AML (acute myeloid leukemia) cell lines^[1].
IC₅₀ & Target	IC₅₀: 24.43 ± 1.08 nM (LSD1), 5.00 ± 0.28 μM (LSD2), >100 μM (MAO-A), >100 μM (MAO-B)^[1]
体外研究 (In Vitro)	LSD1-IN-13 hydrochloride (compound 7e) shows good selectivity over LSD2 (205-fold) and MAOs (>4000-fold)^[1]. LSD1-IN-13 hydrochloride shows potent and selective antiproliferative activity in MV-4-11, with an IC₅₀ of 1.36 μM^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	LSD1-IN-13 hydrochloride (compound 7e) (MV-4-11 xenograft mice, 0-20 mg/kg, Orally, daily for 15 days) suppresses tumor growth significantly in a dose-dependent manner^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	448.02
Formula	C₂₃H₃₀ClN₃O₂S
CAS 号	2170347-90-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Li C, et al. Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem. 2022 Mar 10;65(5):4335-4349.

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LSD1-IN-15

发表于2023年12月8日由上海金畔生物科技有限公司

LSD1-IN-15

LSD1-IN-15 (compound 1b) 是一种有效的 LSD1 抑制剂。LSD1-IN-15 对LSD1-CoREST、MAO-A 和 MAO-B 具有抑制作用，IC₅₀ 值分别为 0.149、0.028 和 0.324 μM。LSD1-IN-15 在前列腺癌 LNCaP 细胞中显示细胞生长阻滞，IC₅₀ 为 9.9 μM。

LSD1-IN-15 Chemical Structure

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生物活性

LSD1-IN-15 (compound 1b) is a potent LSD1 inhibitor. LSD1-IN-15 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.149, 0.028, and 0.327 μM, respectively. LSD1-IN-15 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 9.9 μM^[1].

IC₅₀ & Target

MAO-A

0.028 ± 0. μM (IC₅₀)

MAO-B

0.327 ± 0. μM (IC₅₀)

分子量

328.41

Formula

C₂₂H₂₀N₂O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Fioravanti R, et al. Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity. J Enzyme Inhib Med Chem. 2022 Dec;37(1):973-985.

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LSD1-IN-16

发表于2023年12月8日由上海金畔生物科技有限公司

LSD1-IN-16

LSD1-IN-16 (compound 4b) 是一种有效的 LSD1 抑制剂。LSD1-IN-16 对LSD1-CoREST、MAO-A 和 MAO-B 具有抑制作用，IC₅₀ 值分别为 0.015、0.024 和 0.366 μM。LSD1-IN-16 在前列腺癌 LNCaP 细胞中显示细胞生长阻滞，IC₅₀ 为 15.2 μM。

LSD1-IN-16 Chemical Structure

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生物活性

LSD1-IN-16 (compound 4b) is a potent LSD1 inhibitor. LSD1-IN-16 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.015, 0.024, and 0.366 μM, respectively. LSD1-IN-16 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 15.2 μM^[1].

IC₅₀ & Target

MAO-A

0.024 ± μM (IC₅₀)

MAO-B

0.366 ± μM (IC₅₀)

分子量

334.43

Formula

C₂₀H₁₈N₂OS

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Fioravanti R, et al. Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity. J Enzyme Inhib Med Chem. 2022 Dec;37(1):973-985.

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LSD1-IN-17

发表于2023年12月8日由上海金畔生物科技有限公司

LSD1-IN-17

LSD1-IN-17 (compound 5b) 是一种有效的 LSD1 抑制剂。LSD1-IN-17 对LSD1-CoREST、MAO-A 和 MAO-B 具有抑制作用，IC₅₀ 值分别为 0.005、0.028 和 0.820 μM。LSD1-IN-17 在前列腺癌 LNCaP 细胞中显示细胞生长阻滞，IC₅₀ 为 17.2 μM。

LSD1-IN-17 Chemical Structure

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生物活性

LSD1-IN-17 (compound 5b) is a potent LSD1 inhibitor. LSD1-IN-17 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.005, 0.028, and 0.820 μM, respectively. LSD1-IN-17 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 17.2 μM^[1].

IC₅₀ & Target

MAO-A

0.028 ± 0. μM (IC₅₀)

MAO-B

0.820 ± 0. μM (IC₅₀)

分子量

334.43

Formula

C₂₀H₁₈N₂OS

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Fioravanti R, et al. Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity. J Enzyme Inhib Med Chem. 2022 Dec;37(1):973-985.

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LSD1-IN-18

发表于2023年12月8日由上海金畔生物科技有限公司

LSD1-IN-18

LSD1-IN-18 (compound 7) 是一种有效的，非共价的和选择性的 LSD1 抑制剂，其 K_i 值为 0.156 μM，K_D 为 0.075 μM。LSD1-IN-18 在 THP-1 白血病细胞和 MDA-MB-231 乳腺癌细胞中显示出抗增殖活性，其 IC₅₀ (72 h) 分别为 0.16 和 0.21 μM。

LSD1-IN-18 Chemical Structure

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生物活性	LSD1-IN-18 (compound 7) is a potent, non-covalent and selective LSD1 inhibitor, with K_i of 0.156 μM and K_D of 0.075 μM, respectively. LSD1-IN-18 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC₅₀ (72 h) of 0.16 and 0.21 μM, respectively^[1].
IC₅₀ & Target	K_i of 0.156 μM (LSD1, Lysine-specific demethylase 1)^[1]
分子量	528.69
Formula	C₃₁H₄₀N₆O₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Menna M, et al. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem. 2022 Jul 5;237:114410.

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LSD1-IN-19

发表于2023年12月8日由上海金畔生物科技有限公司

LSD1-IN-19

LSD1-IN-19 (compound 29) 是一种有效的，非共价的和选择性的 LSD1 抑制剂，其 K_i 值为 0.108 μM，K_D 为 0.068 μM。LSD1-IN-19 在 THP-1 白血病细胞和 MDA-MB-231 乳腺癌细胞中显示出抗增殖活性，其 IC₅₀ (72 h) 分别为 0.17 和 0.40 μM。

LSD1-IN-19 Chemical Structure

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生物活性	LSD1-IN-19 (compound 29) is a potent, non-covalent and selective LSD1 inhibitor, with K_i of 0.108 μM and K_D of 0.068 μM, respectively. LSD1-IN-19 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC₅₀ (72 h) of 0.17 and 0.40 μM, respectively^[1].
IC₅₀ & Target	K_i of 0.108 μM (LSD1, Lysine-specific demethylase 1)^[1]
分子量	554.73
Formula	C₃₃H₄₂N₆O₂
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Menna M, et al. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem. 2022 Jul 5;237:114410.

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LSD1-IN-20

发表于2023年12月7日由上海金畔生物科技有限公司

LSD1-IN-20

LSD1-IN-20 (compound 1) 是一种有效的双重非共价 LSD1/G9a 抑制剂，其 K_i 值分别为 0.44 和 0.68 μM。LSD1-IN-20 在 THP-1 白血病细胞和 MDA-MB-231 乳腺癌细胞中显示出抗增殖活性，其 IC₅₀ (72 h) 分别为 0.51 和 1.60 μM。

LSD1-IN-20 Chemical Structure

CAS No. : 1239589-91-3

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生物活性	LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with K_i values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC₅₀ (72 h) of 0.51 and 1.60 μM, respectively^[1].
IC₅₀ & Target	K_i of 0.440 ± 0.05 μM (LSD1), 0.68 ± 0.02 μM (G9a)^[1]
分子量	478.63
Formula	C₂₇H₃₈N₆O₂
CAS 号	1239589-91-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Menna M, et al. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem. 2022 Jul 5;237:114410.

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LSD1-IN-14

发表于2023年11月25日由上海金畔生物科技有限公司

LSD1-IN-14

LSD1-IN-14 是一种有效且具有选择性的 LSD1 抑制剂 (IC₅₀=0.89 μM)。LSD1-IN-14 能显著抑制 A549 和 THP-1 细胞的增殖，能诱导肿瘤细胞的凋亡。

LSD1-IN-14 Chemical Structure

CAS No. : 2698340-11-1

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生物活性

LSD1-IN-14 is a potent and selective LSD1 inhibitor (IC₅₀=0.89 μM). LSD1-IN-14 can significantly inhibit the proliferation of A549 and THP-1 cells and induce the apoptosis of tumor cells^[1].

IC₅₀ & Target

IC₅₀: 0.89 μM (LSD1)^[1]

体外研究
(In Vitro)

LSD1-IN-14 (compound x43) (0-20 μM; 72 hours) has a superior ability to inhibit the proliferation of A549 and THP-1 cells, with IC₅₀ values of 1.62 μM and 1.21 μM, respectively^[1].
LSD1-IN-14 (0-3 μM ;72 hours) significantly upregulates the expression of substrate H3K4me2 and H3K9me2 in a dose-dependent manner^[1].
LSD1-IN-14 (0-3 μM;72 hours) induces the apoptosis of 53.6% of A549 cells in a dose-dependent manner^[1].
LSD1-IN-14 (1 mM; 60 minutes) has excellent stability in human liver microsomes and weak CYP inhibition, with T_1/2 of 103.3 min and Cl_int(mic) of 13.4 μL/min/mg^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	A549 and THP-1^[1]
Concentration:	0-20 μM
Incubation Time:	72 hours
Result:	Showed a superior ability to inhibit the proliferation of A549 and THP-1 cells, with IC50 values of 1.62 μM and 1.21 μM, respectively.

Western Blot Analysis

Cell Line:	A549 cells^[1]
Concentration:	0, 0.3, 1 and 3 μM
Incubation Time:	72 hours
Result:	Significantly upregulated the expression of substrate H3K4me2 and H3K9me2 in a dose-dependent manner.

Apoptosis Analysis

Cell Line:	A549 cells^[1]
Concentration:	0, 0.3, 1 and 3 μM
Incubation Time:	72 hours
Result:	Induced the apoptosis of 53.6% of cells in a dose-dependent manner.

体内研究
(In Vivo)

LSD1-IN-14 (2 mg/kg for i.v., 10 mg/kg for i.g, single) has an acceptable half-life and oral bioavailability^[1].
Pharmacokinetic Parameters of LSD1-IN-14 in male Sprague-Dawley rats^[1].

	IV (2 mg/kg)		IG (10 mg/kg)
C₀ (ng/mL)	575	C_max (ng/mL)	41.1
T_1/2 (h)	1.0	T_1/2 (h)	2.8
Vd_ss (L/kg)	6.6	T_max (h)	0.8
Cl (mL/min/kg)	156	AUC_0-t (ng.h/mL)	126
AUC_0-t (ng.h/mL)	211	AUC_0-∞ (ng.h/mL)	152
AUC_0-∞ (ng.h/mL)	214	Bioacailability (%)	11.9

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	2 mg/kg for i.v., 10 mg/kg for i.g.
Administration:	i.v. and i.g, single
Result:	Showed an acceptable half-life and oral bioavailability.

分子量

365.45

Formula

C₂₁H₂₄FN₅

CAS 号

2698340-11-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wang X, et al. Design, synthesis and biological evaluation of 2-aminopyrimidine-based LSD1 inhibitors. Bioorg Chem. 2022;121:105699.

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LSD1-IN-14

发表于2023年11月25日由上海金畔生物科技有限公司

LSD1-IN-14

LSD1-IN-14 是一种有效且具有选择性的 LSD1 抑制剂 (IC₅₀=0.89 μM)。LSD1-IN-14 能显著抑制 A549 和 THP-1 细胞的增殖，能诱导肿瘤细胞的凋亡。

LSD1-IN-14 Chemical Structure

CAS No. : 2698340-11-1

规格		是否有货
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生物活性

IC₅₀ & Target

IC₅₀: 0.89 μM (LSD1)^[1]

体外研究
(In Vitro)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	A549 and THP-1^[1]
Concentration:	0-20 μM
Incubation Time:	72 hours
Result:	Showed a superior ability to inhibit the proliferation of A549 and THP-1 cells, with IC50 values of 1.62 μM and 1.21 μM, respectively.

Western Blot Analysis

Cell Line:	A549 cells^[1]
Concentration:	0, 0.3, 1 and 3 μM
Incubation Time:	72 hours
Result:	Significantly upregulated the expression of substrate H3K4me2 and H3K9me2 in a dose-dependent manner.

Apoptosis Analysis

Cell Line:	A549 cells^[1]
Concentration:	0, 0.3, 1 and 3 μM
Incubation Time:	72 hours
Result:	Induced the apoptosis of 53.6% of cells in a dose-dependent manner.

体内研究
(In Vivo)

LSD1-IN-14 (2 mg/kg for i.v., 10 mg/kg for i.g, single) has an acceptable half-life and oral bioavailability^[1].
Pharmacokinetic Parameters of LSD1-IN-14 in male Sprague-Dawley rats^[1].

	IV (2 mg/kg)		IG (10 mg/kg)
C₀ (ng/mL)	575	C_max (ng/mL)	41.1
T_1/2 (h)	1.0	T_1/2 (h)	2.8
Vd_ss (L/kg)	6.6	T_max (h)	0.8
Cl (mL/min/kg)	156	AUC_0-t (ng.h/mL)	126
AUC_0-t (ng.h/mL)	211	AUC_0-∞ (ng.h/mL)	152
AUC_0-∞ (ng.h/mL)	214	Bioacailability (%)	11.9

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	2 mg/kg for i.v., 10 mg/kg for i.g.
Administration:	i.v. and i.g, single
Result:	Showed an acceptable half-life and oral bioavailability.

分子量

365.45

Formula

C₂₁H₂₄FN₅

CAS 号

2698340-11-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wang X, et al. Design, synthesis and biological evaluation of 2-aminopyrimidine-based LSD1 inhibitors. Bioorg Chem. 2022;121:105699.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

LSD1-IN-14

发表于2023年11月25日由上海金畔生物科技有限公司

LSD1-IN-14

LSD1-IN-14 是一种有效且具有选择性的 LSD1 抑制剂 (IC₅₀=0.89 μM)。LSD1-IN-14 能显著抑制 A549 和 THP-1 细胞的增殖，能诱导肿瘤细胞的凋亡。

LSD1-IN-14 Chemical Structure

CAS No. : 2698340-11-1

规格		是否有货
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生物活性

IC₅₀ & Target

IC₅₀: 0.89 μM (LSD1)^[1]

体外研究
(In Vitro)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	A549 and THP-1^[1]
Concentration:	0-20 μM
Incubation Time:	72 hours
Result:	Showed a superior ability to inhibit the proliferation of A549 and THP-1 cells, with IC50 values of 1.62 μM and 1.21 μM, respectively.

Western Blot Analysis

Cell Line:	A549 cells^[1]
Concentration:	0, 0.3, 1 and 3 μM
Incubation Time:	72 hours
Result:	Significantly upregulated the expression of substrate H3K4me2 and H3K9me2 in a dose-dependent manner.

Apoptosis Analysis

Cell Line:	A549 cells^[1]
Concentration:	0, 0.3, 1 and 3 μM
Incubation Time:	72 hours
Result:	Induced the apoptosis of 53.6% of cells in a dose-dependent manner.

体内研究
(In Vivo)

LSD1-IN-14 (2 mg/kg for i.v., 10 mg/kg for i.g, single) has an acceptable half-life and oral bioavailability^[1].
Pharmacokinetic Parameters of LSD1-IN-14 in male Sprague-Dawley rats^[1].

	IV (2 mg/kg)		IG (10 mg/kg)
C₀ (ng/mL)	575	C_max (ng/mL)	41.1
T_1/2 (h)	1.0	T_1/2 (h)	2.8
Vd_ss (L/kg)	6.6	T_max (h)	0.8
Cl (mL/min/kg)	156	AUC_0-t (ng.h/mL)	126
AUC_0-t (ng.h/mL)	211	AUC_0-∞ (ng.h/mL)	152
AUC_0-∞ (ng.h/mL)	214	Bioacailability (%)	11.9

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	2 mg/kg for i.v., 10 mg/kg for i.g.
Administration:	i.v. and i.g, single
Result:	Showed an acceptable half-life and oral bioavailability.

分子量

365.45

Formula

C₂₁H₂₄FN₅

CAS 号

2698340-11-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Wang X, et al. Design, synthesis and biological evaluation of 2-aminopyrimidine-based LSD1 inhibitors. Bioorg Chem. 2022;121:105699.

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