Isoscopoletin(Synonyms: 6-Hydroxy-7-methoxycoumarin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Isoscopoletin (Synonyms: 6-Hydroxy-7-methoxycoumarin) 纯度: 98.85%

Isoscopoletin (6-Hydroxy-7-methoxycoumarin) 是艾叶中的一种活性成分。 Isoscopoletin 具有显著的细胞增殖抑制作用,对人类 CCRF-CEM 白血病细胞和耐药亚系 CEM/ADR5000 作用的 IC50 值分别为 4.0 μM 和 1.6 μM。Isoscopoletin (6-Hydroxy-7-methoxycoumarin) 具有抑制 HBV 复制的活性。

Isoscopoletin(Synonyms: 6-Hydroxy-7-methoxycoumarin)

Isoscopoletin Chemical Structure

CAS No. : 776-86-3

规格 价格 是否有货 数量
5 mg ¥3360 In-stock
10 mg ¥5710 In-stock
50 mg   询价  
100 mg   询价  

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生物活性

Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2].

分子量

192.17

Formula

C10H8O4

CAS 号

776-86-3

中文名称

异东莨菪素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (520.37 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.2037 mL 26.0186 mL 52.0373 mL
5 mM 1.0407 mL 5.2037 mL 10.4075 mL
10 mM 0.5204 mL 2.6019 mL 5.2037 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (13.01 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (13.01 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (13.01 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (13.01 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (13.01 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (13.01 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Adams M, et al. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72(9):862-4.

    [2]. Li H, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Med. 2005 Dec;71(12):1128-33.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

5-Geranoxy-7-methoxycoumarin

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

5-Geranoxy-7-methoxycoumarin 

5-Geranoxy-7-methoxycoumarin 是一种具有抗癌、抗真菌和抗菌活性的香豆素。5-Geranoxy-7-methoxycoumarin 诱导细胞凋亡(apoptosis)。

5-Geranoxy-7-methoxycoumarin

5-Geranoxy-7-methoxycoumarin Chemical Structure

CAS No. : 7380-39-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and  antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis[1][2].

体外研究
(In Vitro)

5-Geranoxy-7-methoxycoumarin (12.5-200 µM; 24-72 hours) induces a significant inhibition of cell growth in a time-dependent manner in SW480 cells[1].
5-Geranoxy-7-methoxycoumarin (50 µM;48 hours) promotes DNA fragmentation and causes apoptosis through inhibition of the p38 MAPK signaling pathway in SW480 cells[1].
5-Geranoxy-7-methoxycoumarin (50 µM; 24-48 hours) increases the percentage of cells in the sub G1/G0 phase from 5.3% (in control cells) to 18% after 48 h incubation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SW480
Concentration: 0-20 μM
Incubation Time: 24, 48 and 72 hours
Result: Inhibited cell growth by 67% at 72 hours.

Apoptosis Analysis[1]

Cell Line: SW480 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis.

Cell Cycle Analysis[1]

Cell Line: SW480 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Inhibited cell cycle progression in vitro.

分子量

328.40

Formula

C20H24O4

CAS 号

7380-39-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jaiprakash R Patil, et al. 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta Med. 2013 Mar;79(3-4):219-26.

    [2]. Guo-Ying Zuo, et al. Synergism of coumarins from the Chinese drug Zanthoxylum nitidum with antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). Phytomedicine

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

5-Geranoxy-7-methoxycoumarin

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

5-Geranoxy-7-methoxycoumarin 

5-Geranoxy-7-methoxycoumarin 是一种具有抗癌、抗真菌和抗菌活性的香豆素。5-Geranoxy-7-methoxycoumarin 诱导细胞凋亡(apoptosis)。

5-Geranoxy-7-methoxycoumarin

5-Geranoxy-7-methoxycoumarin Chemical Structure

CAS No. : 7380-39-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and  antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis[1][2].

体外研究
(In Vitro)

5-Geranoxy-7-methoxycoumarin (12.5-200 µM; 24-72 hours) induces a significant inhibition of cell growth in a time-dependent manner in SW480 cells[1].
5-Geranoxy-7-methoxycoumarin (50 µM;48 hours) promotes DNA fragmentation and causes apoptosis through inhibition of the p38 MAPK signaling pathway in SW480 cells[1].
5-Geranoxy-7-methoxycoumarin (50 µM; 24-48 hours) increases the percentage of cells in the sub G1/G0 phase from 5.3% (in control cells) to 18% after 48 h incubation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SW480
Concentration: 0-20 μM
Incubation Time: 24, 48 and 72 hours
Result: Inhibited cell growth by 67% at 72 hours.

Apoptosis Analysis[1]

Cell Line: SW480 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis.

Cell Cycle Analysis[1]

Cell Line: SW480 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Inhibited cell cycle progression in vitro.

分子量

328.40

Formula

C20H24O4

CAS 号

7380-39-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jaiprakash R Patil, et al. 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta Med. 2013 Mar;79(3-4):219-26.

    [2]. Guo-Ying Zuo, et al. Synergism of coumarins from the Chinese drug Zanthoxylum nitidum with antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). Phytomedicine

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

5-Geranoxy-7-methoxycoumarin

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

5-Geranoxy-7-methoxycoumarin 

5-Geranoxy-7-methoxycoumarin 是一种具有抗癌、抗真菌和抗菌活性的香豆素。5-Geranoxy-7-methoxycoumarin 诱导细胞凋亡(apoptosis)。

5-Geranoxy-7-methoxycoumarin

5-Geranoxy-7-methoxycoumarin Chemical Structure

CAS No. : 7380-39-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and  antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis[1][2].

体外研究
(In Vitro)

5-Geranoxy-7-methoxycoumarin (12.5-200 µM; 24-72 hours) induces a significant inhibition of cell growth in a time-dependent manner in SW480 cells[1].
5-Geranoxy-7-methoxycoumarin (50 µM;48 hours) promotes DNA fragmentation and causes apoptosis through inhibition of the p38 MAPK signaling pathway in SW480 cells[1].
5-Geranoxy-7-methoxycoumarin (50 µM; 24-48 hours) increases the percentage of cells in the sub G1/G0 phase from 5.3% (in control cells) to 18% after 48 h incubation[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SW480
Concentration: 0-20 μM
Incubation Time: 24, 48 and 72 hours
Result: Inhibited cell growth by 67% at 72 hours.

Apoptosis Analysis[1]

Cell Line: SW480 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis.

Cell Cycle Analysis[1]

Cell Line: SW480 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Inhibited cell cycle progression in vitro.

分子量

328.40

Formula

C20H24O4

CAS 号

7380-39-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jaiprakash R Patil, et al. 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta Med. 2013 Mar;79(3-4):219-26.

    [2]. Guo-Ying Zuo, et al. Synergism of coumarins from the Chinese drug Zanthoxylum nitidum with antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). Phytomedicine

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

7-Geranyloxy-5-methoxycoumarin

7-Geranyloxy-5-methoxycoumarin

  【编号】:SPR00099

  【产品名称】:7-Geranyloxy-5-methoxycoumarin

  【规格】:10mg

  【用途】:

  7-Geranyloxy-5-methoxycoumarin对照品

  编号:SPR00099
  英文名称:7-Geranyloxy-5-methoxycoumarin
  CAS No.:1432075-68-7
  分 子 式:C20H24O4
  分 子 量:328.408
  类别:上海金畔生物科技有限公司,中药对照品
  作为标准品,对照品或者供研究用,不能直接用于人体。