标签归档：miroestrol

Miroestrol

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Miroestrol 

Miroestrol 是一种高活性植物雌激素。Miroestrol 可以产生致乳作用。Miroestrol 在卵巢切除的小鼠中表现出骨丢失预防和神经保护作用。Miroestrol 还可以降低癌症风险。

Miroestrol

Miroestrol Chemical Structure

CAS No. : 2618-41-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Miroestrol is a highly active phytoestrogen. Miroestrol can produce mammogenic effect. Miroestrol exhibits bone loss prevention and neuroprotective in ovariectomized mice. Miroestrol also can reduce cancer risk[1][2][3][4].

体内研究
(In Vivo)

Miroestrol (0.1-1 mg/kg; s.c. once daily for 60 days) exhibits bone loss prevention via increase of the ratio of osteoprotegerin to receptor activator of nuclear factor kappa B ligand (osteoformation/osteoresorption) in ovariectomized mouse liver[2].
Miroestrol (0.1-1 mg/kg; i.p. once daily for 8 weeks) dose-dependently attenuates ovariectomized-induced cognitive dysfunction in mice[3].
Miroestrol (0.5-5 mg/kg; s.c. once daily for 7 days) suppresses hepatic CYP1A1 activity and CYP1A2 activity, expression of CYP1B1 mRNA and expression of CYP1A1/2 and CYP1B1 protein in β-naphthoflavone-treated mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

358.39

Formula

C20H22O6
CAS 号

2618-41-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kitisripanya T, et, al. A pilot pharmacokinetic study of miroestrol and deoxymiroestrol on rabbit sera using polyclonal antibody-based icELISA analysis. Phytother Res. 2018 Feb;32(2):365-369.

    [2]. Udomsuk L, et, al. Impact of Pueraria candollei var. mirifica and its potent phytoestrogen miroestrol on expression of bone-specific genes in ovariectomized mice. Fitoterapia. 2012 Dec;83(8):1687-92.

    [3]. Monthakantirat O, et, al. Effect of miroestrol on ovariectomy-induced cognitive impairment and lipid peroxidation in mouse brain. Phytomedicine. 2014 Sep 25;21(11):1249-55.

    [4]. Chatuphonprasert W, et, al. Regulation of cancer-related genes – Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt – expression in β-naphthoflavone-treated mice by miroestrol. J Pharm Pharmacol. 2016 Apr;68(4):475-84.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Miroestrol

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Miroestrol 

Miroestrol 是一种高活性植物雌激素。Miroestrol 可以产生致乳作用。Miroestrol 在卵巢切除的小鼠中表现出骨丢失预防和神经保护作用。Miroestrol 还可以降低癌症风险。

Miroestrol

Miroestrol Chemical Structure

CAS No. : 2618-41-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Miroestrol is a highly active phytoestrogen. Miroestrol can produce mammogenic effect. Miroestrol exhibits bone loss prevention and neuroprotective in ovariectomized mice. Miroestrol also can reduce cancer risk[1][2][3][4].

体内研究
(In Vivo)

Miroestrol (0.1-1 mg/kg; s.c. once daily for 60 days) exhibits bone loss prevention via increase of the ratio of osteoprotegerin to receptor activator of nuclear factor kappa B ligand (osteoformation/osteoresorption) in ovariectomized mouse liver[2].
Miroestrol (0.1-1 mg/kg; i.p. once daily for 8 weeks) dose-dependently attenuates ovariectomized-induced cognitive dysfunction in mice[3].
Miroestrol (0.5-5 mg/kg; s.c. once daily for 7 days) suppresses hepatic CYP1A1 activity and CYP1A2 activity, expression of CYP1B1 mRNA and expression of CYP1A1/2 and CYP1B1 protein in β-naphthoflavone-treated mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

358.39

Formula

C20H22O6
CAS 号

2618-41-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kitisripanya T, et, al. A pilot pharmacokinetic study of miroestrol and deoxymiroestrol on rabbit sera using polyclonal antibody-based icELISA analysis. Phytother Res. 2018 Feb;32(2):365-369.

    [2]. Udomsuk L, et, al. Impact of Pueraria candollei var. mirifica and its potent phytoestrogen miroestrol on expression of bone-specific genes in ovariectomized mice. Fitoterapia. 2012 Dec;83(8):1687-92.

    [3]. Monthakantirat O, et, al. Effect of miroestrol on ovariectomy-induced cognitive impairment and lipid peroxidation in mouse brain. Phytomedicine. 2014 Sep 25;21(11):1249-55.

    [4]. Chatuphonprasert W, et, al. Regulation of cancer-related genes – Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt – expression in β-naphthoflavone-treated mice by miroestrol. J Pharm Pharmacol. 2016 Apr;68(4):475-84.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Miroestrol

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Miroestrol 

Miroestrol 是一种高活性植物雌激素。Miroestrol 可以产生致乳作用。Miroestrol 在卵巢切除的小鼠中表现出骨丢失预防和神经保护作用。Miroestrol 还可以降低癌症风险。

Miroestrol

Miroestrol Chemical Structure

CAS No. : 2618-41-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Miroestrol is a highly active phytoestrogen. Miroestrol can produce mammogenic effect. Miroestrol exhibits bone loss prevention and neuroprotective in ovariectomized mice. Miroestrol also can reduce cancer risk[1][2][3][4].

体内研究
(In Vivo)

Miroestrol (0.1-1 mg/kg; s.c. once daily for 60 days) exhibits bone loss prevention via increase of the ratio of osteoprotegerin to receptor activator of nuclear factor kappa B ligand (osteoformation/osteoresorption) in ovariectomized mouse liver[2].
Miroestrol (0.1-1 mg/kg; i.p. once daily for 8 weeks) dose-dependently attenuates ovariectomized-induced cognitive dysfunction in mice[3].
Miroestrol (0.5-5 mg/kg; s.c. once daily for 7 days) suppresses hepatic CYP1A1 activity and CYP1A2 activity, expression of CYP1B1 mRNA and expression of CYP1A1/2 and CYP1B1 protein in β-naphthoflavone-treated mice[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

358.39

Formula

C20H22O6
CAS 号

2618-41-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kitisripanya T, et, al. A pilot pharmacokinetic study of miroestrol and deoxymiroestrol on rabbit sera using polyclonal antibody-based icELISA analysis. Phytother Res. 2018 Feb;32(2):365-369.

    [2]. Udomsuk L, et, al. Impact of Pueraria candollei var. mirifica and its potent phytoestrogen miroestrol on expression of bone-specific genes in ovariectomized mice. Fitoterapia. 2012 Dec;83(8):1687-92.

    [3]. Monthakantirat O, et, al. Effect of miroestrol on ovariectomy-induced cognitive impairment and lipid peroxidation in mouse brain. Phytomedicine. 2014 Sep 25;21(11):1249-55.

    [4]. Chatuphonprasert W, et, al. Regulation of cancer-related genes – Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt – expression in β-naphthoflavone-treated mice by miroestrol. J Pharm Pharmacol. 2016 Apr;68(4):475-84.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务