MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor as a therapeutic agent.

308.33

C₁₇H₁₆N₄O₂

1426928-20-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xu W, et al. Update on the Development of MNK Inhibitors as Therapeutic Agents. J Med Chem. 2021 Sep 17.

MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor as a therapeutic agent.

308.33

C₁₇H₁₆N₄O₂

1426928-20-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xu W, et al. Update on the Development of MNK Inhibitors as Therapeutic Agents. J Med Chem. 2021 Sep 17.

MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor as a therapeutic agent.

308.33

C₁₇H₁₆N₄O₂

1426928-20-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xu W, et al. Update on the Development of MNK Inhibitors as Therapeutic Agents. J Med Chem. 2021 Sep 17.

MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC₅₀s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner^[1].

MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC₅₀s of 0.3896µM, 0.4092 µM for TMD-8, DOHH-2 cells, respectively^[1].
MNK1/2-IN-6 (0.25, 0.5, 1 µM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

448.52

C₂₇H₂₄N₆O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bu H, et al. Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors. Bioorg Med Chem. 2021; 40:116186.

MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC₅₀s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner^[1].

MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC₅₀s of 0.3896µM, 0.4092 µM for TMD-8, DOHH-2 cells, respectively^[1].
MNK1/2-IN-6 (0.25, 0.5, 1 µM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

448.52

C₂₇H₂₄N₆O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bu H, et al. Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors. Bioorg Med Chem. 2021; 40:116186.

MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC₅₀s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner^[1].

MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC₅₀s of 0.3896µM, 0.4092 µM for TMD-8, DOHH-2 cells, respectively^[1].
MNK1/2-IN-6 (0.25, 0.5, 1 µM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

448.52

C₂₇H₂₄N₆O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bu H, et al. Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors. Bioorg Med Chem. 2021; 40:116186.