上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
mTOR/HDAC6-IN-1
mTOR/HDAC6-IN-1 是一种有效的哺乳动物雷帕霉素 (mTOR) 和组蛋白去乙酰酶 (HDAC6) 的双重抑制剂 (mTOR 和 HDAC6 的 IC50s 分别为 133.7 nM 和 56 nM)。mTOR/HDAC6-IN-1 可诱导明显的细胞自噬 (autophagy)、细胞凋亡 (apoptosis),以及抑制迁移。mTOR/HDAC6-IN-1 具有研究三阴性乳腺癌 (TNBC) 的潜力。
mTOR/HDAC6-IN-1 Chemical Structure
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生物活性 |
mTOR/HDAC6-IN-1 is a potent mTOR and HDAC6 dual inhibitor (IC50s of 133.7 nM and 56 nM for mTOR and HDAC6, respectively). mTOR/HDAC6-IN-1 can induce significant autophagy, apoptosis and suppress migration. mTOR/HDAC6-IN-1 has potential to research Triple-negative breast cancer (TNBC)[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
mTOR/HDAC6-IN-1 (compound 10g) (0-100 μM; 48 hours) has a medium anti-proliferation activity with IC50 of 8.4 μM, 10.6 μM and 14.3 μM in MDA-MB-231, MDA-MB-436 and MDA-MB-468 cells at 48h[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay
Apoptosis Analysis
Cell Autophagy Assay
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分子量 |
397.86 |
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Formula |
C20H20ClN5O2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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