Oenothein B 是一种二聚体大环鞣花单宁，具有广泛的药理活性，包括抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。Oenothein B 是一种有效且特异性的聚 (ADP-核糖) 糖水解酶抑制剂。
Oenothein B Chemical Structure
CAS No. : 104987-36-2
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2].
体外研究 (In Vitro)
Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure[1]. Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage[1]. Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax)[1]. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours Arrested cells in the G1 phase. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Effectively inhibited the proliferation of A549 cells.
Apoptosis Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
Induced apoptosis in A549 cells.
Cell Cycle Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
Arrested cells in the G1 phase.
Western Blot Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
体内研究 (In Vivo)
Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice[3].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1571.10
Formula
C68H50O44
CAS 号
104987-36-2
中文名称
月见草素B
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Xiaodong Pei, et al. Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway. Chem Biol Interact. 2019 Jan 25;298:112-120.
[3]. Satoshi Okuyama, et al. Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain. Int J Mol Sci. 2013 May 7;14(5):9767-78.
Oenothein B 是一种二聚体大环鞣花单宁，具有广泛的药理活性，包括抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。Oenothein B 是一种有效且特异性的聚 (ADP-核糖) 糖水解酶抑制剂。
Oenothein B Chemical Structure
CAS No. : 104987-36-2
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2].
体外研究 (In Vitro)
Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure[1]. Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage[1]. Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax)[1]. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours Arrested cells in the G1 phase. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Effectively inhibited the proliferation of A549 cells.
Apoptosis Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
Induced apoptosis in A549 cells.
Cell Cycle Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
Arrested cells in the G1 phase.
Western Blot Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
体内研究 (In Vivo)
Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice[3].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1571.10
Formula
C68H50O44
CAS 号
104987-36-2
中文名称
月见草素B
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Xiaodong Pei, et al. Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway. Chem Biol Interact. 2019 Jan 25;298:112-120.
[3]. Satoshi Okuyama, et al. Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain. Int J Mol Sci. 2013 May 7;14(5):9767-78.
Oenothein B 是一种二聚体大环鞣花单宁，具有广泛的药理活性，包括抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。Oenothein B 是一种有效且特异性的聚 (ADP-核糖) 糖水解酶抑制剂。
Oenothein B Chemical Structure
CAS No. : 104987-36-2
规格
是否有货
5 mg
询价
10 mg
询价
25 mg
询价
* Please select Quantity before adding items.
生物活性
Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2].
体外研究 (In Vitro)
Oenothein B (15-45 µM; 12-72 hours) has a dose- and time-dependent inhibition rate effect on A549 cells in the range of 12 hours, 24 hours, 36 hours, 48 hours, 60 hours and 72 hours of exposure[1]. Oenothein B (15-45 µM; 24 hours) effectively inhibits the proliferation of A549 cells by inducing apoptosis and arresting cells at G1 stage[1]. Oenothein B (15-45 µM; 24 hours) not only increases the level of intracellular reactive oxygen species (ROS), but also induces the upregulation of intracellular apoptotic triggers (cleavage caspase-3, PARP, cytochrome c level in the cytosol, Bax)[1]. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours Arrested cells in the G1 phase. A549 cells[1] 15 µM, 30 µM and 45 µM 24 hours BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Effectively inhibited the proliferation of A549 cells.
Apoptosis Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
Induced apoptosis in A549 cells.
Cell Cycle Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
Arrested cells in the G1 phase.
Western Blot Analysis[1]
Cell Line:
A549 cells
Concentration:
15 µM, 30 µM and 45 µM
Incubation Time:
24 hours
Result:
BAX, p53, cytochrome c (cytoplasm) and PARP were unregulated significantly; Anti-apoptotic Bcl-2 was decreased significantly in a concentration-dependent manner.
体内研究 (In Vivo)
Oenothein B (100-300 mg/kg; p.o.) has the ability to reduce neuroinflammation in the brain during systemic inflammation in ICR mice[3].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
1571.10
Formula
C68H50O44
CAS 号
104987-36-2
中文名称
月见草素B
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Xiaodong Pei, et al. Oenothein B inhibits human non-small cell lung cancer A549 cell proliferation by ROS-mediated PI3K/Akt/NF-κB signaling pathway. Chem Biol Interact. 2019 Jan 25;298:112-120.
[3]. Satoshi Okuyama, et al. Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain. Int J Mol Sci. 2013 May 7;14(5):9767-78.
