DBCO PEG Folic acid, Folate PEG DBCO Cat. No. PG2-DBFA-5k 5000 Da 5 mg修饰性聚乙二醇

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DBCO PEG Folic acid, Folate PEG DBCO

Cat. No. PG2-DBFA-5k
Specification 5000 Da
Unit Size 5 mg
Price $385.00

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Synonym: Folic acid PEG DBCO, Folate PEG DBCO, DBCO PEG folate, DBCO PEG Folic acid.

Description:

DBCO PEG Folic acid, also called DBCO PEG folate, is one of Nanocs' folic acid PEG derivatives that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG folate derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. Folic acid, is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule for numerous biological functions. It participates in the synthesis, repairing and methylation of DNA as well as to act as a cofactor in many biological reactions. DBCO functional folic acid can be easily attached to azide functionalized molecules, particles or solid surfaces.

Physical Properties:

  • Yellow solid;
  • Soluble in DMSO;
  • Reactive group: DBCO;
  • Reactive to: Azide;
  • Applications: Click chemistry;
  • Purity: >95%;

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction solution.
  • Add DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage Conditions:

  • Store at -20 0C. Desicate. Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

mPEG-DBCO, PEG Dibenzylcyclooctyne Cat. No. PG1-DB-5k 5000 Da 25 mg修饰性聚乙二醇

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mPEG-DBCO, PEG Dibenzylcyclooctyne

Cat. No. PG1-DB-5k mPEG-DBCO, PEG Dibenzylcyclooctyne           Cat. No. PG1-DB-5k     5000 Da    25 mg
Specification 5000 Da
Unit Size 25 mg
Price $385.00

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Synonym: DBCO PEG, mPEG DBCO, Methoxy PEG DBCO, Polyethylene glycol DBCO

Description:

mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies, biopolymers and particles via copper free Click Chemistry reaction.

Product Specifications:

  • Form: Solid
  • Color: Yellow to light yellow
  • Solubility: Soluble in water
  • Reactive group: DBCO (Dibenzooctyne)
  • Reactive to: Azide group (-N3)
  • Purity: >95%

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction buffer.
  • Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage:

  • Store at -20 0C; Desiccate; Avoid frequent thaw and freeze.

References:

Click here to see hundred of publications using Nanocs PEGs.

Documents
  • SDS
  • DataSheet

Related Products
PG1-DB-5k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-2k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-10k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-20k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-30k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-40k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-1k , mPEG-DBCO, PEG Dibenzylcyclooctyne

Tags: DBCO PEG,

Biotin PEG Maleimide, Maleimide PEG Biotin Cat. No. PG2-BNML-600 600 Da 100 mg修饰性聚乙二醇

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Biotin PEG Maleimide, Maleimide PEG Biotin

Cat. No. PG2-BNML-600 Biotin PEG Maleimide, Maleimide PEG Biotin           Cat. No. PG2-BNML-600     600 Da    100 mg
Specification 600 Da
Unit Size 100 mg
Price $425.00

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Synonym: Maleimide PEG Biotin, Biotin PEG600 Maleimide, Maleimide PEG600 Biotin

Description:

Biotin PEG Maleimide is one of Nanocs pegylated Biotinylation reagents with an activated maleimide group. Maleimide is able to react with thiol/sulfhydryl groups rapidly and specifically at neutral pH. Reaction between maleimide and thiol group enables fast conjugation of biotin tag to targeted molecules or material surfaces. Resulted biotin moiety can bind to avidin or streptavidin with high affinity. PEG linker between biotin and maleimide offers better water solubility, reduced steric hydrance and enhanced stability. 

Physical Properties:

  • Form: Semi-solid
  • Color: Off-White
  • Solubility: Soluble in water
  • Reactive group: Maleimide
  • Reactive to: Thiol/Sulfhydryl (-SH)
  • Applications: Thiol biotinylation
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C. Desiccate. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-BNML-5k , Biotin PEG Maleimide
PG2-BNML-3k , Biotin PEG Maleimide
PG2-BNTH-600 , Thiol PEG Biotin, HS-PEG-Biotin

Rhodamine PEG hydroxyl, RB-PEG-OH Cat. No. PG2-OHRB-3k 3400 Da 10 mg修饰性聚乙二醇

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Rhodamine PEG hydroxyl, RB-PEG-OH

Cat. No. PG2-OHRB-3k Rhodamine PEG hydroxyl, RB-PEG-OH           Cat. No. PG2-OHRB-3k     3400 Da    10 mg
Specification 3400 Da
Unit Size 10 mg
Price $385.00

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Description:

Rhodamine B labeled polyethylene glycol is a fluorescent PEG derivative that has a maximum absorption at 570 nm and emission around 595 nm. Rhodamine B can be easily traced from its pink color and red fluorescence. Additional functionality allows these fluorescent PEG derivatives to be easily conjugated to other molecule or material surfaces.

Physical Properties:

  • Pink or dark red solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Epoxide PEG, mPEG-EPO Cat. No. PG1-EP-750 750 Da 100 mg修饰性聚乙二醇

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Epoxide PEG, mPEG-EPO

Cat. No. PG1-EP-750 Epoxide PEG, mPEG-EPO           Cat. No. PG1-EP-750     750 Da    100 mg
Specification 750 Da
Unit Size 100 mg
Price $385.00

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Description:

Epoxyl functionctional PEG, EPO PEG is an amino (-NH2) and hydroxyl group reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with available amino or hydroxyl groups. Epoxyl PEGs react readily with amine groups at a pH of from 8.0 to 9.5.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C. Dessicated.
Documents
  • SDS
  • DataSheet

Stearic acid PEG aldehyde Cat. No. PG2-ALST-2k 2000 Da 50 mg修饰性聚乙二醇

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Stearic acid PEG aldehyde

Cat. No. PG2-ALST-2k
Specification 2000 Da
Unit Size 50 mg
Price $325.00

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Description:

Nanocs Stearic acid PEG aldehyde is an 18C fatty acid lipid PEG derivative with amine reactive aldehyde group. Aldeyde PEG is a common N-terminal amine groupation reagent. The reaction between aldehyde group with the α-amine at the N-terminus produces an intermediate Schiff base. Further reduction with hydride will form a stable C-N bond. PEG aldehydes react with n-terminus amine groups at a pH of from 5.0 to 9.5. Higher pH will result in multiple Pegylation with both terminal and lysine groups.

Physical Properties:

  • Off-white/white solid;
  • Soluble in warm water, DMSO, DMF;

Storage Conditions:

  • Store at -20 0C

Reaction Procedures:

Generally, a 5- to 10-fold molar excess of PEG aldehyde over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer: Amine-free aqueous buffer, pH 5.0~6.5.
  • PEG aldehyde stock solution: 50 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in pegylation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add PEG aldehyde stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. Allow mixture agitates at room temperature for 2~4 hrs at room temperature or overnight 4 0C. After reaction, C=N bond can be reduced by sodium borohydride. Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Lipoic acid PEG azide, LA-PEG-N3 Cat. No. PG2-AZLA-2k 2000 Da 100 mg修饰性聚乙二醇

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Lipoic acid PEG azide, LA-PEG-N3

Cat. No. PG2-AZLA-2k Lipoic acid PEG azide, LA-PEG-N3           Cat. No. PG2-AZLA-2k     2000 Da    100 mg
Specification 2000 Da
Unit Size 100 mg
Price $385.00

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Description:

Lipoic acid PEG azide is one of Nanocs’ surface reactive PEG derivatives that have a lipoic acid moiety on one PEG terminus and an azide group on the other PEG end. Lipoic acid, also known as thioctic acid, is an important bioactive molecule participating in various biological processes. PEG functionalized lipoic acid can be used to bind to metallic particle or film surface with its disulfide bond. Lipoic acid group has high affinity to metallic surfaces and have been widely used for gold nanoparticles and quantum dots surface modification. Azide group can react with linear alkye or strain-promoted cyclooctyne through so called Click Chemistry. PEGylated lipoic acid azide is water soluble and can be used directly in aqueous buffer.

Physical Properties:

  • Off-yellow solid.
  • Soluble in regular aqeous solution as well as most organic solvents;
  • Reactive group: Azide (-N3):
  • Reactive toward: Alkyne;

Storage Conditions:

  • Store at -20 0C.
Documents
  • SDS
  • DataSheet

DSPE-PEG-NHS Cat. No. PG2-DSNS-3k 3400 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE-PEG-NHS

Cat. No. PG2-DSNS-3k DSPE-PEG-NHS           Cat. No. PG2-DSNS-3k     3400 Da    100 mg
Specification 3400 Da
Unit Size 100 mg
Price $385.00

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DSPE-PEG-NHS, MW 3400

Synonym: 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine PEG NHS, NHS PEG DSPE, DSPE PEG Succinimidyl ester

 

DSPE PEG NHS is one of Nanocs reactive phospholipid PEG conjugates that can react with primary amine groups. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. PEG backbone, on the other hand, offers good hydrophilicity and water solubility. Succinimidyl ester (NHS) on the other PEG terminal reacts with primary amine groups efficiently at pH 8~10. NHS PEG DSPE thus can be easily incorporated into liposome and other nanoparticles via the reaction of NHS and amine. DSPE PEG NHS is one of most commonly used reactive phospholipids to conjugate antibodies, proteins, peptides or other substrates to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated molecules. Nanocs has developed a comprehensive collection of chemical reactive phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule modification, formulation and delivery. 

Product Information:

  • Form: Solid;
  • Color: White;
  • Solubility: Soluble in chloroform, warm water;
  • Reactive group: Succinimidyl NHS Ester;
  • Reactive to: Primary amine group (-NH2);
  • Lipid type: C18, saturated;
  • Purity: >90%;

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-DSNS-2k , DSPE-PEG-NHS
PG2-AMDS-3k , DSPE PEG Amine, DSPE-PEG-NH2
PG2-DBDS-3k , DBCO PEG DSPE, DSPE PEG DBCO

DBCO PEG NHS Cat. No. PG2-DBNS-20k 20000 Da 20 mg修饰性聚乙二醇

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DBCO PEG NHS

Cat. No. PG2-DBNS-20k DBCO PEG NHS           Cat. No. PG2-DBNS-20k     20000 Da    20 mg
Specification 20000 Da
Unit Size 20 mg
Price $485.00

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Description:

DBCO PEG NHS is one of Nanocs’ amine reactive PEG derivatives can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO (Dibenzylcyclooctyne) PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white or light yellow solid;
  • Soluble in regular aqeous solution;
  • Functional group: DBCO;
  • Reactive toward: Azide (-N3):
  • PEG MW: 20000 Da;

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction buffer.
  • Add DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage Conditions:

  • Store at -20 0C.
Documents
  • SDS
  • DataSheet

mPEG-DBCO, PEG Dibenzylcyclooctyne Cat. No. PG1-DB-2k 2000 Da 25 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

mPEG-DBCO, PEG Dibenzylcyclooctyne

Cat. No. PG1-DB-2k mPEG-DBCO, PEG Dibenzylcyclooctyne           Cat. No. PG1-DB-2k     2000 Da    25 mg
Specification 2000 Da
Unit Size 25 mg
Price $425.00

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Synonym: DBCO PEG, mPEG DBCO, Methoxy PEG DBCO, Polyethylene glycol DBCO

Description:

mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies, biopolymers and particles via copper free Click Chemistry reaction.

Product Specifications:

  • Form: Solid
  • Color: Yellow to light yellow
  • Solubility: Soluble in water
  • Reactive group: DBCO (Dibenzooctyne)
  • Reactive to: Azide group (-N3)
  • Purity: >95%

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction buffer.
  • Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage:

  • Store at -20 0C; Desiccate; Avoid frequent thaw and freeze.

References:

Click here to see hundred of publications using Nanocs PEGs.

Documents
  • SDS
  • DataSheet

Related Products
PG1-DB-5k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-2k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-10k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-20k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-30k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-40k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-1k , mPEG-DBCO, PEG Dibenzylcyclooctyne

Tags: DBCO PEG,

Biotin PEG Maleimide, Maleimide PEG Biotin Cat. No. PG2-BNML-400 400 Da 100 mg修饰性聚乙二醇

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Biotin PEG Maleimide, Maleimide PEG Biotin

Cat. No. PG2-BNML-400 Biotin PEG Maleimide, Maleimide PEG Biotin           Cat. No. PG2-BNML-400     400 Da    100 mg
Specification 400 Da
Unit Size 100 mg
Price $485.00

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Synonym: Maleimide PEG Biotin, Biotin PEG400 Maleimide, Maleimide PEG400 Biotin

Description:

Biotin PEG Maleimide is one of Nanocs pegylated Biotinylation reagents with an activated maleimide group. Maleimide is able to react with thiol/sulfhydryl groups rapidly and specifically at neutral pH. Reaction between maleimide and thiol group enables fast conjugation of biotin tag to targeted molecules or material surfaces. Resulted biotin moiety can bind to avidin or streptavidin with high affinity. PEG linker between biotin and maleimide offers better water solubility, reduced steric hydrance and enhanced stability. 

Physical Properties:

  • Form: Semi-solid
  • Color: Off-White
  • Solubility: Soluble in water
  • Reactive group: Maleimide
  • Reactive to: Thiol/Sulfhydryl (-SH)
  • Applications: Thiol biotinylation
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C. Desiccate. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-BNML-5k , Biotin PEG Maleimide
PG2-BNML-3k , Biotin PEG Maleimide

DSPE-PEG-NHS Cat. No. PG2-DSNS-2k 2000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE-PEG-NHS

Cat. No. PG2-DSNS-2k DSPE-PEG-NHS           Cat. No. PG2-DSNS-2k     2000 Da    100 mg
Specification 2000 Da
Unit Size 100 mg
Price $385.00

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Synonym: 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine PEG NHS, NHS PEG DSPE, DSPE PEG Succinimidyl ester, DSPE Polyethylene glycol NHS

DSPE PEG NHS is one of Nanocs reactive phospholipid PEG conjugates that can react with primary amine groups. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. PEG backbone, on the other hand, offers good hydrophilicity and water solubility. Succinimidyl ester (NHS) on the other PEG terminal reacts with primary amine groups efficiently at pH 8~10. NHS PEG DSPE thus can be easily incorporated into liposome and other nanoparticles via the reaction of NHS and amine. DSPE PEG NHS is one of most commonly used reactive phospholipids to conjugate antibodies, proteins, peptides or other substrates to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated molecules. Nanocs has developed a comprehensive collection of chemical reactive phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule modification, formulation and delivery. 

Product Information:

  • Form: Solid;
  • Color: White;
  • Solubility: Soluble in chloroform, warm water;
  • Reactive group: Succinimidyl NHS Ester;
  • Reactive to: Primary amine group (-NH2);
  • Lipid type: C18, saturated;
  • Purity: >95%;

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.

References:

Click here to check hundreds of publications using Nanocs PEGs.

Documents
  • SDS
  • DataSheet

Related Products
PG1-DS-5k , DSPE PEG, mPEG-DSPE
PG2-DSNS-5k , DSPE-PEG-NHS
PG2-DSNS-3k , DSPE-PEG-NHS
PG2-DSNS-2k , DSPE-PEG-NHS
PG2-DSNS-10k , DSPE-PEG-NHS
PG2-DSNS-1k , DSPE-PEG-NHS
PG2-DSNS-20k , DSPE-PEG-NHS
PG2-DSML-2k , DSPE PEG Maleimide, DSPE-PEG-MAL
PG2-AMDS-2k , DSPE PEG Amine, DSPE-PEG-NH2
PG2-AMDS-20k , DSPE PEG Amine, DSPE-PEG-NH2

DBCO PEG NHS Cat. No. PG2-DBNS-30k 30000 Da 20 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO PEG NHS

Cat. No. PG2-DBNS-30k DBCO PEG NHS           Cat. No. PG2-DBNS-30k     30000 Da    20 mg
Specification 30000 Da
Unit Size 20 mg
Price $485.00

Qty Add to Cart

Description:

DBCO PEG NHS is one of Nanocs’ amine reactive PEG derivatives can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO (Dibenzylcyclooctyne) PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white or light yellow solid;
  • Soluble in regular aqeous solution;
  • Functional group: DBCO;
  • Reactive toward: Azide (-N3):
  • PEG MW: 30000 Da;

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction buffer.
  • Add DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage Conditions:

  • Store at -20 0C.
Documents
  • SDS
  • DataSheet

mPEG-DBCO, PEG Dibenzylcyclooctyne Cat. No. PG1-DB-10k 10000 Da 25 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

mPEG-DBCO, PEG Dibenzylcyclooctyne

Cat. No. PG1-DB-10k mPEG-DBCO, PEG Dibenzylcyclooctyne           Cat. No. PG1-DB-10k     10000 Da    25 mg
Specification 10000 Da
Unit Size 25 mg
Price $485.00

Qty Add to Cart

Synonym: DBCO PEG, mPEG DBCO, Methoxy PEG DBCO, Polyethylene glycol DBCO

Description:

mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies, biopolymers and particles via copper free Click Chemistry reaction.

Product Specifications:

  • Form: Solid
  • Color: Yellow to light yellow
  • Solubility: Soluble in water
  • Reactive group: DBCO (Dibenzooctyne)
  • Reactive to: Azide group (-N3)
  • Purity: >95%

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction buffer.
  • Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage:

  • Store at -20 0C; Desiccate; Avoid frequent thaw and freeze.

References:

Click here to see hundred of publications using Nanocs PEGs.

Documents
  • SDS
  • DataSheet

Related Products
PG1-DB-5k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-2k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-10k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-20k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-30k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-40k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-1k , mPEG-DBCO, PEG Dibenzylcyclooctyne

Tags: DBCO PEG,

DSPE-PEG-NHS Cat. No. PG2-DSNS-10k 10000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE-PEG-NHS

Cat. No. PG2-DSNS-10k DSPE-PEG-NHS           Cat. No. PG2-DSNS-10k     10000 Da    100 mg
Specification 10000 Da
Unit Size 100 mg
Price $385.00

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DSPE-PEG-NHS, MW 10000

Synonym: 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine PEG NHS, NHS PEG DSPE, DSPE PEG Succinimidyl ester

DSPE PEG NHS is one of Nanocs reactive phospholipid PEG conjugates that can react with primary amine groups. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. PEG backbone, on the other hand, offers good hydrophilicity and water solubility. Succinimidyl ester (NHS) on the other PEG terminal reacts with primary amine groups efficiently at pH 8~10. NHS PEG DSPE thus can be easily incorporated into liposome and other nanoparticles via the reaction of NHS and amine. DSPE PEG NHS is one of most commonly used reactive phospholipids to conjugate antibodies, proteins, peptides or other substrates to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated molecules. Nanocs has developed a comprehensive collection of chemical reactive phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule modification, formulation and delivery. 

Product Information:

  • Form: Solid;
  • Color: White;
  • Solubility: Soluble in chloroform, warm water;
  • Reactive group: Succinimidyl NHS Ester;
  • Reactive to: Primary amine group (-NH2);
  • Lipid type: C18, saturated;
  • Purity: >90%;

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-DSNS-2k , DSPE-PEG-NHS
PG2-DSML-2k , DSPE PEG Maleimide, DSPE-PEG-MAL
PG2-BNDS-2k , DSPE PEG Biotin
PG2-AMDS-2k , DSPE PEG Amine, DSPE-PEG-NH2
PG2-CADS-2k , DSPE PEG Acid, DSPE-PEG-COOH
PG2-CADS-20k , DSPE PEG Acid, DSPE-PEG-COOH

DBCO PEG Folic acid Cat. No. PG2-DBFA-2k-1 2000 Da 5 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO PEG Folic acid

Cat. No. PG2-DBFA-2k-1
Specification 2000 Da
Unit Size 5 mg
Price $385.00

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Description:

DBCO PEG Folic acid, also called DBCO PEG folate, is one of Nanocs’ folic acid PEG derivatives that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG folate derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. Folic acid, is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule for numerous biological functions. It participates in the synthesis, repairing and methylation of DNA as well as to act as a cofactor in many biological reactions. DBCO functional folic acid can be easily attached to azide functionalized molecules, particles or solid surfaces.

Physical Properties:

  • Yellow solid;
  • Soluble in DMSO;

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction solution.
  • Add DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage Conditions:

  • Store at -20 0C. Desicate. Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

mPEG-DBCO, PEG Dibenzylcyclooctyne Cat. No. PG1-DB-20k 20000 Da 25 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

mPEG-DBCO, PEG Dibenzylcyclooctyne

Cat. No. PG1-DB-20k mPEG-DBCO, PEG Dibenzylcyclooctyne           Cat. No. PG1-DB-20k     20000 Da    25 mg
Specification 20000 Da
Unit Size 25 mg
Price $485.00

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Methoxy PEG DBCO, MW 550, 750, 1000, 2000, 3400, 5000, 10k, 20k, 30k, 40k

Description:

mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies, biopolymers and particles via copper free Click Chemistry reaction.

Product Specifications:

  • Appearance: Light yellow to white solid, semi-solid depends on molecular weight of PEG;
  • Solubility: Soluble in water, ethanol, DMSO, etc.;
  • Reactivity: DBCO reacts with azide group (-N3).

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction buffer.
  • Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage:

  • Store at -20 0C; Desiccate; Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG1-DB-5k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-2k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-10k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-1k , mPEG-DBCO, PEG Dibenzylcyclooctyne

Tags: DBCO PEG,

Tos-PEG3-O-C1-CH3COO(Synonyms: PROTAC Linker 6)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Tos-PEG3-O-C1-CH3COO (Synonyms: PROTAC Linker 6)

Tos-PEG3-O-C1-CH3COO (PROTAC Linker 6) 是一种 PROTAC linker,属于 PEG 类。Tos-PEG3-O-C1-CH3COO 可用于合成 PROTAC 分子。

Tos-PEG3-O-C1-CH3COO(Synonyms: PROTAC Linker 6)

Tos-PEG3-O-C1-CH3COO Chemical Structure

CAS No. : 855120-17-1

规格 是否有货
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250 mg   询价  
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生物活性

Tos-PEG3-O-C1-CH3COO (PROTAC Linker 6) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

376.42

Formula

C16H24O8S

CAS 号

855120-17-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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Tos-PEG4-NH-Boc(Synonyms: PROTAC Linker 7)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Tos-PEG4-NH-Boc (Synonyms: PROTAC Linker 7)

Tos-PEG4-NH-Boc (PROTAC Linker 7) 是一种 PROTAC linker,属于 PEG 类。Tos-PEG4-NH-Boc 可用于合成 PROTAC 分子。

Tos-PEG4-NH-Boc(Synonyms: PROTAC Linker 7)

Tos-PEG4-NH-Boc Chemical Structure

CAS No. : 1246999-33-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

447.54

Formula

C20H33NO8S

CAS 号

1246999-33-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PEG3-O-CH2COOH(Synonyms: PROTAC Linker 8)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PEG3-O-CH2COOH (Synonyms: PROTAC Linker 8)

PEG3-O-CH2COOH (PROTAC Linker 8) 是一种 PROTAC linker,属于 PEG 类。PEG3-O-CH2COOH 可用于合成 SNIPER 分子。

PEG3-O-CH2COOH(Synonyms: PROTAC Linker 8)

PEG3-O-CH2COOH Chemical Structure

CAS No. : 51951-05-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker can be used in the synthesis of SNIPERs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PEG3-O-CH2COOH (Compound 15b) is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. SNIPERs that recruit inhibitor of the apoptosis protein (IAP) ubiquitin ligases to specifically degrade targeted proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

208.21

Formula

C8H16O6

CAS 号

51951-05-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务