标签归档：peg

Amino-PEG4-C2-amine

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Amino-PEG4-C2-amine  纯度: ≥98.0%

Amino-PEG4-C2-amine 是一种 PROTAC linker (4 个单元)，属于 PEG 类。Bis-Amino-PEG5 可用于合成一系列 PROTAC 分子。

Amino-PEG4-C2-amine

Amino-PEG4-C2-amine Chemical Structure

CAS No. : 68960-97-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥500 In-stock
100 mg ￥500 In-stock
250 mg ￥1000 In-stock
500 mg   询价  
1 g   询价  

* Please select Quantity before adding items.

生物活性

Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

236.31

Formula

C10H24N2O4
CAS 号

68960-97-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

H2O : 120 mg/mL (507.81 mM; Need ultrasonic)

DMSO : 100 mg/mL (423.17 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.2317 mL 21.1586 mL 42.3173 mL
5 mM 0.8463 mL 4.2317 mL 8.4635 mL
10 mM 0.4232 mL 2.1159 mL 4.2317 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (12.70 mM); Clear solution

    此方案可获得 ≥ 3 mg/mL (12.70 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 30.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (12.70 mM); Clear solution

    此方案可获得 ≥ 3 mg/mL (12.70 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 30.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (12.70 mM); Clear solution

    此方案可获得 ≥ 3 mg/mL (12.70 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 30.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

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Me-PEG4-Me

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Me-PEG4-Me  纯度: 98.57%

Me-PEG4-Me 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Me-PEG4-Me

Me-PEG4-Me Chemical Structure

CAS No. : 143-24-8

规格 价格 是否有货 数量
100 mg ￥350 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

222.28

Formula

C10H22O5
CAS 号

143-24-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Desthiobiotin-PEG4-acid

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Desthiobiotin-PEG4-acid 

Desthiobiotin-PEG4-acid 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Desthiobiotin-PEG4-acid

Desthiobiotin-PEG4-acid Chemical Structure

规格 价格 是否有货
50 mg ￥4800 询问价格 & 货期
100 mg ￥7600 询问价格 & 货期
250 mg ￥14000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Desthiobiotin-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

461.55

Formula

C21H39N3O8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Bis-sulfone-PEG4-DBCO

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Bis-sulfone-PEG4-DBCO 

Bis-sulfone-PEG4-DBCO 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Bis-sulfone-PEG4-DBCO

Bis-sulfone-PEG4-DBCO Chemical Structure

CAS No. : 1854034-70-0

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价
50 mg 询价

* Please select Quantity before adding items.

生物活性

Bis-sulfone-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1006.19

Formula

C54H59N3O12S2
CAS 号

1854034-70-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.

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Bis-sulfone-PEG3-Azide

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Bis-sulfone-PEG3-Azide 

Bis-sulfone-PEG3-Azide 是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

Bis-sulfone-PEG3-Azide

Bis-sulfone-PEG3-Azide Chemical Structure

CAS No. : 1802908-01-5

规格 价格 是否有货
5 mg ￥3200 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Bis-sulfone-PEG3-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

700.82

Formula

C33H40N4O9S2
CAS 号

1802908-01-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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Pomalidomide-amino-PEG4-NH2

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pomalidomide-amino-PEG4-NH2 

Pomalidomide-amino-PEG4-NH2 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker，可用于合成 PROTAC。

Pomalidomide-amino-PEG4-NH2

Pomalidomide-amino-PEG4-NH2 Chemical Structure

CAS No. : 2331259-44-8

规格 是否有货
25 mg 询价
50 mg 询价
100 mg 询价

* Please select Quantity before adding items.

生物活性

Pomalidomide-amino-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

506.51

Formula

C23H30N4O9
CAS 号

2331259-44-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

    [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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Mal-PEG2-NH2 TFA

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Mal-PEG2-NH2 TFA  纯度: 98.09%

Mal-PEG2-NH2 (TFA) 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Mal-PEG2-NH2 TFA

Mal-PEG2-NH2 TFA Chemical Structure

CAS No. : 660843-23-2

规格 价格 是否有货 数量
100 mg ￥5800 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

342.27

Formula

C12H17F3N2O6
CAS 号

660843-23-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

APN-PEG36-tetrazine

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

APN-PEG36-tetrazine  纯度: 96.05%

APN-PEG36-tetrazine 是 APN-PEG4-tetrazine 的类似物。APN-PEG4-tetrazine 是一种可降解 (cleavable) 的含 4 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

APN-PEG36-tetrazine

APN-PEG36-tetrazine Chemical Structure

规格 是否有货
5 mg Check price and availability
10 mg Check price and availability

* Please select Quantity before adding items.

生物活性

APN-PEG36-tetrazine is an analogue of APN-PEG4-tetrazine. APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1997.30

Formula

C26H161N7O38
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
参考文献

  • [1]. Beck A, et, al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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Propargyl-PEG2-CH2COOH

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Propargyl-PEG2-CH2COOH 

Propargyl-PEG2-CH2COOH 是一种基于 PEG 的 PROTAC linker，可用于合成 PROTACs。

Propargyl-PEG2-CH2COOH

Propargyl-PEG2-CH2COOH Chemical Structure

CAS No. : 944561-46-0

规格 价格 是否有货 数量
50 mg ￥1100 In-stock
100 mg ￥1700 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

分子量

202.20

Formula

C9H14O5
CAS 号

944561-46-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献

  • [1]. Guangrong Zheng, et al. Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof. WO2017184995A1.

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Pomalidomide-PEG4-C2-NH2(Synonyms: Cereblon Ligand-Linker Conjugates 8; E3 Ligase Ligand-Linker Conjugates 22)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pomalidomide-PEG4-C2-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 8; E3 Ligase Ligand-Linker Conjugates 22) 纯度: 95.11%

Pomalidomide-PEG4-C2-NH2 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG 的 linker。

Pomalidomide-PEG4-C2-NH2(Synonyms: Cereblon Ligand-Linker Conjugates 8; E3 Ligase Ligand-Linker Conjugates 22)

Pomalidomide-PEG4-C2-NH2 Chemical Structure

CAS No. : 2225940-52-1

规格 价格 是否有货
100 mg ￥3500 询问价格 & 货期
500 mg ￥13500 询问价格 & 货期
1 g ￥25000 询问价格 & 货期
2 g ￥35000 询问价格 & 货期

* Please select Quantity before adding items.

Pomalidomide-PEG4-C2-NH2 的其他形式现货产品:

Pomalidomide-PEG4-C2-NH2 hydrochloride

生物活性

Pomalidomide-PEG4-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

IC50 & Target

Cereblon

 

分子量

492.52

Formula

C23H32N4O8
CAS 号

2225940-52-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (101.52 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0304 mL 10.1519 mL 20.3037 mL
5 mM 0.4061 mL 2.0304 mL 4.0607 mL
10 mM 0.2030 mL 1.0152 mL 2.0304 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Jian Jin, et al. Compositions and methods for treating ezh2-mediated cancer. WO2018081530A1.

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Tos-PEG3

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tos-PEG3  纯度: 97.39%

Tos-PEG3 是基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。Tos-PEG3 (结构 1) 可用于合成 3′-氨基氧基寡核苷酸固体载体。

Tos-PEG3

Tos-PEG3 Chemical Structure

CAS No. : 77544-68-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1380 In-stock
100 mg ￥1250 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3′-aminooxy oligonucleotides solid supports[1].

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

304.36

Formula

C13H20O6S
CAS 号

77544-68-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

Ethanol : 100 mg/mL (328.56 mM; Need ultrasonic)

DMSO : 100 mg/mL (328.56 mM; Need ultrasonic and warming)

H2O : 10 mg/mL (32.86 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2856 mL 16.4279 mL 32.8558 mL
5 mM 0.6571 mL 3.2856 mL 6.5712 mL
10 mM 0.3286 mL 1.6428 mL 3.2856 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Noël M, et al. Solid Supports for the Synthesis of 3′-Aminooxy Deoxy- or Ribo-oligonucleotides and Their 3′-Conjugation by Oxime Ligation.J Org Chem. 2019 Nov 15;84(22):14854-14860.

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Pentafluorophenyl PEG, mPEG-PFP Cat. No. PG1-PFP-10k 10000 Da 100 mg修饰性聚乙二醇

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Pentafluorophenyl PEG, mPEG-PFP

Cat. No. PG1-PFP-10k Pentafluorophenyl PEG, mPEG-PFP Cat. No. PG1-PFP-10k 10000 Da 100 mg
Specification 10000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Nanocs PFP (pentafluorophenyl) functionalized polyethylene glycol (PEG-PFP) is an amine (-NH2) reactive PEG derivative that can be used to modify molecules with available amine groups. Compared to NHS PEG, PFP PEG has greater reactivity, it can react with both prirmary and secondary amine groups at pH 7~9. Nanocs provides a number of PFP functionalized PEG derivatives that can be used for controlled amine pegylation applications.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Solubility: 10 mg/mL, clear in water, chloroform, DMSO.
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C, desiccate. PFP PEG tends to hydrolyze from moisture. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

DSPE PEG Maleimide, DSPE-PEG-MAL Cat. No. PG2-DSML-10k 10000 Da 100 mg修饰性聚乙二醇

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DSPE PEG Maleimide, DSPE-PEG-MAL

Cat. No. PG2-DSML-10k DSPE PEG Maleimide, DSPE-PEG-MAL Cat. No. PG2-DSML-10k 10000 Da 100 mg
Specification 10000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Synonym: Maleimide PEG DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine PEG Maleimide, DSPE-PEG-Mal.

Description:

DSPE PEG Maleimide is one of Nanocs reactive phospholipid PEG  reagents that can react with sulfhydryl (thiol, -SH) groups. DSPE (1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine)  is a saturated 18C phospholipid that is highly hydrophobic. PEG linker (polyethylene glycol), on the other hand, offers good hydrophilicity and water solubility. Maleimide functional DSPE PEG has excellent reactivity towards sulfhydryl/thiol groups derived from various molecules. Reaction between maleimide and thiolproceeds easily at neutral pH. Maleimide PEG DSPE is one of most commonly used reactive phospholipids to conjugate antibodies, peptides or other ligands to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated drugs. Nanocs has developed a comprehensive collection of thiol reactive maleimide phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule drug formulation and delivery.

Physical Properties:

  • Form: Solid powder;
  • Color: White;
  • Solubility: Soluble in chloroform and warm water;
  • Reactive group: Maleimide;
  • Reactive to: Sulfhydryl (-SH);
  • Lipid type: 18C PE, saturated;
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-CADS-20k , DSPE PEG Acid, DSPE-PEG-COOH

Methoxy PEG Aldehyde, mPEG-CH2CHO Cat. No. PG1-AL-5k-1 5000 Da 1 g修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Methoxy PEG Aldehyde, mPEG-CH2CHO

Cat. No. PG1-AL-5k-1 Methoxy PEG Aldehyde, mPEG-CH2CHO Cat. No. PG1-AL-5k-1 5000 Da 1 g
Specification 5000 Da
Unit Size 1 g
Price $385.00

Qty Add to Cart

PEG Aldehyde Description:

Aldeyde PEG is an amine reactive PEG derivative that can be used to modify biomolecules via available amine groups. The reaction between aldehyde group with ε-amine of lysine residues and the α-amine at the N-terminus produces an intermediate Schiff base. Further reduction with hydride will form a stable C-N bond. PEG aldehydes react with amine groups at a pH of from 5.5 to 9.5. Higher pH will result in multiple Pegylation with both terminal and lysine groups. Aldehyde PEG is a commonly used PEG reagent for n-terminus pegylation in proteins or peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C

Reaction Procedures:

Generally, a 10- to 50-fold molar excess of PEG aldehyde over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer: Amine-free aqueous buffer, pH 6~8.5.
  • PEG aldehyde stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in pegylation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add PEG aldehyde stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. Allow mixture agitates at room temperature for 2~4 hrs at room temperature or overnight 4 0C. After reaction, C=N bond can be reduced by sodium borohydride. Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Pentafluorophenyl PEG, mPEG-PFP Cat. No. PG1-PFP-20k 20000 Da 100 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Pentafluorophenyl PEG, mPEG-PFP

Cat. No. PG1-PFP-20k Pentafluorophenyl PEG, mPEG-PFP Cat. No. PG1-PFP-20k 20000 Da 100 mg
Specification 20000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Nanocs PFP (pentafluorophenyl) functionalized polyethylene glycol (PEG-PFP) is an amine (-NH2) reactive PEG derivative that can be used to modify molecules with available amine groups. Compared to NHS PEG, PFP PEG has greater reactivity, it can react with both prirmary and secondary amine groups at pH 7~9. Nanocs provides a number of PFP functionalized PEG derivatives that can be used for controlled amine pegylation applications.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Solubility: 10 mg/mL, clear in water, chloroform, DMSO.
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C, desiccate. PFP PEG tends to hydrolyze from moisture. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

DSPE PEG Maleimide, DSPE-PEG-MAL Cat. No. PG2-DSML-1k 1000 Da 100 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE PEG Maleimide, DSPE-PEG-MAL

Cat. No. PG2-DSML-1k DSPE PEG Maleimide, DSPE-PEG-MAL Cat. No. PG2-DSML-1k 1000 Da 100 mg
Specification 1000 Da
Unit Size 100 mg
Price $425.00

Qty Add to Cart

Synonym: Maleimide PEG DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine PEG Maleimide, DSPE-PEG-Mal.

Description:

DSPE PEG Maleimide is one of Nanocs reactive phospholipid PEG  reagents that can react with sulfhydryl (thiol, -SH) groups. DSPE (1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine)  is a saturated 18C phospholipid that is highly hydrophobic. PEG linker (polyethylene glycol), on the other hand, offers good hydrophilicity and water solubility. Maleimide functional DSPE PEG has excellent reactivity towards sulfhydryl/thiol groups derived from various molecules. Reaction between maleimide and thiolproceeds easily at neutral pH. Maleimide PEG DSPE is one of most commonly used reactive phospholipids to conjugate antibodies, peptides or other ligands to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated drugs. Nanocs has developed a comprehensive collection of thiol reactive maleimide phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule drug formulation and delivery.

Physical Properties:

  • Form: Solid powder;
  • Color: White;
  • Solubility: Soluble in chloroform and warm water;
  • Reactive group: Maleimide;
  • Reactive to: Sulfhydryl (-SH);
  • Lipid type: 18C PE, saturated;
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-CADS-1k , DSPE PEG Acid, DSPE-PEG-COOH

DOPE PEG, mPEG-DOPE Cat. No. PG1-DO-5k 5000 Da 50 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DOPE PEG, mPEG-DOPE

Cat. No. PG1-DO-5k
Specification 5000 Da
Unit Size 50 mg
Price $485.00

Qty Add to Cart

Description:

1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine (DOPE) conjugated Polyethylene Glycol, DOPE PEG is an unsaturated C18 phospholipid PEG conjugate which has both hydrophilicity and hydrophobility. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies, peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Thiol PEG, mPEG-SH Cat. No. PG1-TH-5k-1 5000 Da 1 g修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Thiol PEG, mPEG-SH

Cat. No. PG1-TH-5k-1 Thiol PEG, mPEG-SH Cat. No. PG1-TH-5k-1 5000 Da 1 g
Specification 5000 Da
Unit Size 1 g
Price $325.00

Qty Add to Cart

Synonym: PEG thiol, mPEG-SH, HS-PEG, Polyethylene glycol thiol, mPEG5000 Thiol, Thiol PEG5000

Description:

Thiol functionalized methoxyl polyethylene glycol, PEG thiol (mPEG-SH) is one of Nanocs monofunctional PEG derivatives that can be used to modify proteins, peptides and other materials. Thiol groups also have high affinity to gold surface and are widely used for gold nanoparticles or gold film modification. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Form: Solid
  • Color: White
  • Solubility: Soluble in water
  • Functional group: Thiol (-SH)
  • Purity: >95%
  • Applications: Surface modification, bioconjugation

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.

References:

Click here to see hundreds of publications using Nanocs PEGs

Documents
  • SDS
  • DataSheet

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Azido PEG OPSS, N3-PEG-OPSS Cat. No. PG2-AZOS-3k 3400 Da 100 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Azido PEG OPSS, N3-PEG-OPSS

Cat. No. PG2-AZOS-3k
Specification 3400 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Azide/azido functionalized polyethylene glycol (N3-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials. Azide group can react with alkyne in aqueous solution catalyzed by copper. It can also be reduced into amine group easily while another functional group can be react with other molecules or functional groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

PEG Aldehyde, mPEG-CH2CHO Cat. No. PG1-AL-5k-2 5000 Da 5 g修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG Aldehyde, mPEG-CH2CHO

Cat. No. PG1-AL-5k-2 PEG Aldehyde, mPEG-CH2CHO Cat. No. PG1-AL-5k-2 5000 Da 5 g
Specification 5000 Da
Unit Size 5 g
Price $785.00

Qty Add to Cart

PEG Aldehyde Description:

Aldeyde PEG is an amine reactive PEG derivative that can be used to modify biomolecules via available amine groups. The reaction between aldehyde group with ε-amine of lysine residues and the α-amine at the N-terminus produces an intermediate Schiff base. Further reduction with hydride will form a stable C-N bond. PEG aldehydes react with amine groups at a pH of from 5.5 to 9.5. Higher pH will result in multiple Pegylation with both terminal and lysine groups. Aldehyde PEG is a commonly used PEG reagent for n-terminus pegylation in proteins or peptides.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C

Reaction Procedures:

Generally, a 10- to 50-fold molar excess of PEG aldehyde over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

  • Pegylation buffer: Amine-free aqueous buffer, pH 6~8.5.
  • PEG aldehyde stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in pegylation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add PEG aldehyde stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. Allow mixture agitates at room temperature for 2~4 hrs at room temperature or overnight 4 0C. After reaction, C=N bond can be reduced by sodium borohydride. Conjugate can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet