Biotin PEG Maleimide, Maleimide PEG Biotin Cat. No. PG2-BNML-400 400 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Biotin PEG Maleimide, Maleimide PEG Biotin

Cat. No. PG2-BNML-400 Biotin PEG Maleimide, Maleimide PEG Biotin           Cat. No. PG2-BNML-400     400 Da    100 mg
Specification 400 Da
Unit Size 100 mg
Price $485.00

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Synonym: Maleimide PEG Biotin, Biotin PEG400 Maleimide, Maleimide PEG400 Biotin

Description:

Biotin PEG Maleimide is one of Nanocs pegylated Biotinylation reagents with an activated maleimide group. Maleimide is able to react with thiol/sulfhydryl groups rapidly and specifically at neutral pH. Reaction between maleimide and thiol group enables fast conjugation of biotin tag to targeted molecules or material surfaces. Resulted biotin moiety can bind to avidin or streptavidin with high affinity. PEG linker between biotin and maleimide offers better water solubility, reduced steric hydrance and enhanced stability. 

Physical Properties:

  • Form: Semi-solid
  • Color: Off-White
  • Solubility: Soluble in water
  • Reactive group: Maleimide
  • Reactive to: Thiol/Sulfhydryl (-SH)
  • Applications: Thiol biotinylation
  • Purity: >95%

Storage Conditions:

  • Store at -20 0C. Desiccate. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-BNML-5k , Biotin PEG Maleimide
PG2-BNML-3k , Biotin PEG Maleimide

DSPE-PEG-NHS Cat. No. PG2-DSNS-2k 2000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE-PEG-NHS

Cat. No. PG2-DSNS-2k DSPE-PEG-NHS           Cat. No. PG2-DSNS-2k     2000 Da    100 mg
Specification 2000 Da
Unit Size 100 mg
Price $385.00

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Synonym: 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine PEG NHS, NHS PEG DSPE, DSPE PEG Succinimidyl ester, DSPE Polyethylene glycol NHS

DSPE PEG NHS is one of Nanocs reactive phospholipid PEG conjugates that can react with primary amine groups. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. PEG backbone, on the other hand, offers good hydrophilicity and water solubility. Succinimidyl ester (NHS) on the other PEG terminal reacts with primary amine groups efficiently at pH 8~10. NHS PEG DSPE thus can be easily incorporated into liposome and other nanoparticles via the reaction of NHS and amine. DSPE PEG NHS is one of most commonly used reactive phospholipids to conjugate antibodies, proteins, peptides or other substrates to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated molecules. Nanocs has developed a comprehensive collection of chemical reactive phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule modification, formulation and delivery. 

Product Information:

  • Form: Solid;
  • Color: White;
  • Solubility: Soluble in chloroform, warm water;
  • Reactive group: Succinimidyl NHS Ester;
  • Reactive to: Primary amine group (-NH2);
  • Lipid type: C18, saturated;
  • Purity: >95%;

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.

References:

Click here to check hundreds of publications using Nanocs PEGs.

Documents
  • SDS
  • DataSheet

Related Products
PG1-DS-5k , DSPE PEG, mPEG-DSPE
PG2-DSNS-5k , DSPE-PEG-NHS
PG2-DSNS-3k , DSPE-PEG-NHS
PG2-DSNS-2k , DSPE-PEG-NHS
PG2-DSNS-10k , DSPE-PEG-NHS
PG2-DSNS-1k , DSPE-PEG-NHS
PG2-DSNS-20k , DSPE-PEG-NHS
PG2-DSML-2k , DSPE PEG Maleimide, DSPE-PEG-MAL
PG2-AMDS-2k , DSPE PEG Amine, DSPE-PEG-NH2
PG2-AMDS-20k , DSPE PEG Amine, DSPE-PEG-NH2

DBCO PEG NHS Cat. No. PG2-DBNS-30k 30000 Da 20 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO PEG NHS

Cat. No. PG2-DBNS-30k DBCO PEG NHS           Cat. No. PG2-DBNS-30k     30000 Da    20 mg
Specification 30000 Da
Unit Size 20 mg
Price $485.00

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Description:

DBCO PEG NHS is one of Nanocs’ amine reactive PEG derivatives can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO (Dibenzylcyclooctyne) PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white or light yellow solid;
  • Soluble in regular aqeous solution;
  • Functional group: DBCO;
  • Reactive toward: Azide (-N3):
  • PEG MW: 30000 Da;

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction buffer.
  • Add DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage Conditions:

  • Store at -20 0C.
Documents
  • SDS
  • DataSheet

mPEG-DBCO, PEG Dibenzylcyclooctyne Cat. No. PG1-DB-10k 10000 Da 25 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

mPEG-DBCO, PEG Dibenzylcyclooctyne

Cat. No. PG1-DB-10k mPEG-DBCO, PEG Dibenzylcyclooctyne           Cat. No. PG1-DB-10k     10000 Da    25 mg
Specification 10000 Da
Unit Size 25 mg
Price $485.00

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Synonym: DBCO PEG, mPEG DBCO, Methoxy PEG DBCO, Polyethylene glycol DBCO

Description:

mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies, biopolymers and particles via copper free Click Chemistry reaction.

Product Specifications:

  • Form: Solid
  • Color: Yellow to light yellow
  • Solubility: Soluble in water
  • Reactive group: DBCO (Dibenzooctyne)
  • Reactive to: Azide group (-N3)
  • Purity: >95%

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction buffer.
  • Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage:

  • Store at -20 0C; Desiccate; Avoid frequent thaw and freeze.

References:

Click here to see hundred of publications using Nanocs PEGs.

Documents
  • SDS
  • DataSheet

Related Products
PG1-DB-5k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-2k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-10k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-20k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-30k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-40k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-1k , mPEG-DBCO, PEG Dibenzylcyclooctyne

Tags: DBCO PEG,

DSPE-PEG-NHS Cat. No. PG2-DSNS-10k 10000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE-PEG-NHS

Cat. No. PG2-DSNS-10k DSPE-PEG-NHS           Cat. No. PG2-DSNS-10k     10000 Da    100 mg
Specification 10000 Da
Unit Size 100 mg
Price $385.00

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DSPE-PEG-NHS, MW 10000

Synonym: 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine PEG NHS, NHS PEG DSPE, DSPE PEG Succinimidyl ester

DSPE PEG NHS is one of Nanocs reactive phospholipid PEG conjugates that can react with primary amine groups. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. PEG backbone, on the other hand, offers good hydrophilicity and water solubility. Succinimidyl ester (NHS) on the other PEG terminal reacts with primary amine groups efficiently at pH 8~10. NHS PEG DSPE thus can be easily incorporated into liposome and other nanoparticles via the reaction of NHS and amine. DSPE PEG NHS is one of most commonly used reactive phospholipids to conjugate antibodies, proteins, peptides or other substrates to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated molecules. Nanocs has developed a comprehensive collection of chemical reactive phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule modification, formulation and delivery. 

Product Information:

  • Form: Solid;
  • Color: White;
  • Solubility: Soluble in chloroform, warm water;
  • Reactive group: Succinimidyl NHS Ester;
  • Reactive to: Primary amine group (-NH2);
  • Lipid type: C18, saturated;
  • Purity: >90%;

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-DSNS-2k , DSPE-PEG-NHS
PG2-DSML-2k , DSPE PEG Maleimide, DSPE-PEG-MAL
PG2-BNDS-2k , DSPE PEG Biotin
PG2-AMDS-2k , DSPE PEG Amine, DSPE-PEG-NH2
PG2-CADS-2k , DSPE PEG Acid, DSPE-PEG-COOH
PG2-CADS-20k , DSPE PEG Acid, DSPE-PEG-COOH

DBCO PEG Folic acid Cat. No. PG2-DBFA-2k-1 2000 Da 5 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO PEG Folic acid

Cat. No. PG2-DBFA-2k-1
Specification 2000 Da
Unit Size 5 mg
Price $385.00

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Description:

DBCO PEG Folic acid, also called DBCO PEG folate, is one of Nanocs’ folic acid PEG derivatives that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG folate derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. Folic acid, is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule for numerous biological functions. It participates in the synthesis, repairing and methylation of DNA as well as to act as a cofactor in many biological reactions. DBCO functional folic acid can be easily attached to azide functionalized molecules, particles or solid surfaces.

Physical Properties:

  • Yellow solid;
  • Soluble in DMSO;

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction solution.
  • Add DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage Conditions:

  • Store at -20 0C. Desicate. Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

mPEG-DBCO, PEG Dibenzylcyclooctyne Cat. No. PG1-DB-20k 20000 Da 25 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

mPEG-DBCO, PEG Dibenzylcyclooctyne

Cat. No. PG1-DB-20k mPEG-DBCO, PEG Dibenzylcyclooctyne           Cat. No. PG1-DB-20k     20000 Da    25 mg
Specification 20000 Da
Unit Size 25 mg
Price $485.00

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Methoxy PEG DBCO, MW 550, 750, 1000, 2000, 3400, 5000, 10k, 20k, 30k, 40k

Description:

mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies, biopolymers and particles via copper free Click Chemistry reaction.

Product Specifications:

  • Appearance: Light yellow to white solid, semi-solid depends on molecular weight of PEG;
  • Solubility: Soluble in water, ethanol, DMSO, etc.;
  • Reactivity: DBCO reacts with azide group (-N3).

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction buffer.
  • Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage:

  • Store at -20 0C; Desiccate; Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG1-DB-5k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-2k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-10k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-1k , mPEG-DBCO, PEG Dibenzylcyclooctyne

Tags: DBCO PEG,

Tos-PEG3-O-C1-CH3COO(Synonyms: PROTAC Linker 6)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Tos-PEG3-O-C1-CH3COO (Synonyms: PROTAC Linker 6)

Tos-PEG3-O-C1-CH3COO (PROTAC Linker 6) 是一种 PROTAC linker,属于 PEG 类。Tos-PEG3-O-C1-CH3COO 可用于合成 PROTAC 分子。

Tos-PEG3-O-C1-CH3COO(Synonyms: PROTAC Linker 6)

Tos-PEG3-O-C1-CH3COO Chemical Structure

CAS No. : 855120-17-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Tos-PEG3-O-C1-CH3COO (PROTAC Linker 6) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

376.42

Formula

C16H24O8S

CAS 号

855120-17-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Tos-PEG4-NH-Boc(Synonyms: PROTAC Linker 7)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Tos-PEG4-NH-Boc (Synonyms: PROTAC Linker 7)

Tos-PEG4-NH-Boc (PROTAC Linker 7) 是一种 PROTAC linker,属于 PEG 类。Tos-PEG4-NH-Boc 可用于合成 PROTAC 分子。

Tos-PEG4-NH-Boc(Synonyms: PROTAC Linker 7)

Tos-PEG4-NH-Boc Chemical Structure

CAS No. : 1246999-33-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

447.54

Formula

C20H33NO8S

CAS 号

1246999-33-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PEG3-O-CH2COOH(Synonyms: PROTAC Linker 8)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PEG3-O-CH2COOH (Synonyms: PROTAC Linker 8)

PEG3-O-CH2COOH (PROTAC Linker 8) 是一种 PROTAC linker,属于 PEG 类。PEG3-O-CH2COOH 可用于合成 SNIPER 分子。

PEG3-O-CH2COOH(Synonyms: PROTAC Linker 8)

PEG3-O-CH2COOH Chemical Structure

CAS No. : 51951-05-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker can be used in the synthesis of SNIPERs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PEG3-O-CH2COOH (Compound 15b) is a PROTAC linker can be used in the synthesis of a series of SNIPER(ER)s. SNIPERs that recruit inhibitor of the apoptosis protein (IAP) ubiquitin ligases to specifically degrade targeted proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

208.21

Formula

C8H16O6

CAS 号

51951-05-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Bis-Tos-PEG4(Synonyms: PROTAC Linker 16)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Bis-Tos-PEG4 (Synonyms: PROTAC Linker 16) 纯度: 98.61%

Bis-Tos-PEG4 (PROTAC Linker 16) 是一种 PROTAC linker,属于 PEG 类。Bis-Tos-PEG4 可用于合成 PROTAC 分子。

Bis-Tos-PEG4(Synonyms: PROTAC Linker 16)

Bis-Tos-PEG4 Chemical Structure

CAS No. : 37860-51-8

规格 价格 是否有货 数量
100 mg ¥500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

502.60

Formula

C22H30O9S2

CAS 号

37860-51-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

NH2-PEG5-C2-NH-Boc(Synonyms: PROTAC Linker 17)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

NH2-PEG5-C2-NH-Boc (Synonyms: PROTAC Linker 17)

NH2-PEG5-C2-NH-Boc (PROTAC Linker 17) 是一种 PROTAC linker,属于 PEG 类。NH2-PEG5-C2-NH-Boc 可用于合成 PROTAC 分子。

NH2-PEG5-C2-NH-Boc(Synonyms: PROTAC Linker 17)

NH2-PEG5-C2-NH-Boc Chemical Structure

CAS No. : 189209-27-6

规格 价格 是否有货 数量
100 mg ¥1100 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NH2-PEG5-C2-NH-Boc (PROTAC Linker 17) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

380.48

Formula

C17H36N2O7

CAS 号

189209-27-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

DSPE-PEG-NHS Cat. No. PG2-DSNS-1k 1000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DSPE-PEG-NHS

Cat. No. PG2-DSNS-1k DSPE-PEG-NHS           Cat. No. PG2-DSNS-1k     1000 Da    100 mg
Specification 1000 Da
Unit Size 100 mg
Price $425.00

Qty Add to Cart

DSPE-PEG-NHS, MW 1000

Synonym:1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine PEG NHS, NHS PEG DSPE, DSPE PEG Succinimidyl ester

 

DSPE PEG NHS is one of Nanocs reactive phospholipid PEG conjugates that can react with primary amine groups. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon phospholipid that is highly hydrophobic. PEG backbone, on the other hand, offers good hydrophilicity and water solubility. Succinimidyl ester (NHS) on the other PEG terminal reacts with primary amine groups efficiently at pH 8~10. NHS PEG DSPE thus can be easily incorporated into liposome and other nanoparticles via the reaction of NHS and amine. DSPE PEG NHS is one of most commonly used reactive phospholipids to conjugate antibodies, proteins, peptides or other substrates to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated molecules. Nanocs has developed a comprehensive collection of chemical reactive phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule modification, formulation and delivery. 

Product Information:

  • Form: Solid;
  • Color: White;
  • Solubility: Soluble in chloroform, warm water;
  • Reactive group: Succinimidyl NHS Ester;
  • Reactive to: Primary amine group (-NH2);
  • Lipid type: C18, saturated;
  • Purity: >90%;

Storage Conditions:

  • Store at -20 0C.  Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG2-DSNS-2k , DSPE-PEG-NHS
PG2-CADS-1k , DSPE PEG Acid, DSPE-PEG-COOH

Carboxylic PEG acid, mPEG-COOH Cat. No. PG1-CA-5k-1 5000 Da 1 g修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Carboxylic PEG acid, mPEG-COOH

Cat. No. PG1-CA-5k-1
Specification 5000 Da
Unit Size 1 g
Price $385.00

Qty Add to Cart

Description:

Carboxylic acid functionalized methoxyl polyethylene glycol, PEG acid (mPEG-COOH) is a mono reactive PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccate. Protect from light. Avoid frequent thaw and freeze.

*Note: Structure showed here mainly represents the functional groups derived from PEG. Exact linker may not show. Contact us if you have any concern about the linker.

Documents
  • SDS
  • DataSheet

Azido PEG Thiol, N3-PEG-SH Cat. No. PG2-AZTH-5k 5000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Azido PEG Thiol, N3-PEG-SH

Cat. No. PG2-AZTH-5k Azido PEG Thiol, N3-PEG-SH           Cat. No. PG2-AZTH-5k     5000 Da    100 mg
Specification 5000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Azide/azido functionalized polyethylene glycol (N3-PEG-X) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials. Azide group can react with alkyne in aqueous solution catalyzed by copper. It can also be reduced into amine group easily while another functional group can be react with other molecules or functional groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

DBCO-PEG4-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

DBCO-PEG4-NHS ester  纯度: 97.97%

DBCO-PEG4-NHS ester 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

DBCO-PEG4-NHS ester

DBCO-PEG4-NHS ester Chemical Structure

CAS No. : 1427004-19-0

规格 价格 是否有货 数量
5 mg ¥1800 In-stock
10 mg ¥3000 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

生物活性

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

649.69

Formula

C34H39N3O10

CAS 号

1427004-19-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
In Vitro: 

DMSO : 83.33 mg/mL (128.26 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5392 mL 7.6960 mL 15.3920 mL
5 mM 0.3078 mL 1.5392 mL 3.0784 mL
10 mM 0.1539 mL 0.7696 mL 1.5392 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.20 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (3.20 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (3.20 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.08 mg/mL (3.20 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.20 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (3.20 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

DBCO PEG Folic acid Cat. No. PG2-DBFA-1k 1000 Da 5 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO PEG Folic acid

Cat. No. PG2-DBFA-1k
Specification 1000 Da
Unit Size 5 mg
Price $385.00

Qty Add to Cart

Description:

DBCO PEG Folic acid, also called DBCO PEG folate, is one of Nanocs’ folic acid PEG derivatives that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG folate derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. Folic acid, is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule for numerous biological functions. It participates in the synthesis, repairing and methylation of DNA as well as to act as a cofactor in many biological reactions. DBCO functional folic acid can be easily attached to azide functionalized molecules, particles or solid surfaces.

Physical Properties:

  • Yellow solid;
  • Soluble in DMSO;

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction solution.
  • Add DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage Conditions:

  • Store at -20 0C. Desicate. Protect from light. Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

mPEG-DBCO, PEG Dibenzylcyclooctyne Cat. No. PG1-DB-30k 30000 Da 25 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

mPEG-DBCO, PEG Dibenzylcyclooctyne

Cat. No. PG1-DB-30k mPEG-DBCO, PEG Dibenzylcyclooctyne           Cat. No. PG1-DB-30k     30000 Da    25 mg
Specification 30000 Da
Unit Size 25 mg
Price $485.00

Qty Add to Cart

Methoxy PEG DBCO, MW 550, 750, 1000, 2000, 3400, 5000, 10k, 20k, 30k, 40k

Description:

mPEG DBCO, also called methoxy PEG DBCO, is a pegylated DBCO (dibenzocyclooctyne) derivative that can react with azide group without need any metal catalyst. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free Click reaction, is a bioorthogaonal reaction that enables the conjugation of two molecules in aqueous solution. PEG DBCO derivatives have excellent water solubility, possess fast kinetics and stability in aqueous buffer. They are one of the best pegylation reagents to modify proteins, peptides, antibodies, biopolymers and particles via copper free Click Chemistry reaction.

Product Specifications:

  • Appearance: Light yellow to white solid, semi-solid depends on molecular weight of PEG;
  • Solubility: Soluble in water, ethanol, DMSO, etc.;
  • Reactivity: DBCO reacts with azide group (-N3).

Copper-free Click reaction procedures:

  • Prepare the azide-containing reagents in reaction buffer.
  • Add PEG DBCO reagents to azide containing reagents. Add 1 mol equivalent of limiting reagent to 1.5~3.0 mol equivalents of abundance reagent.
  • Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4 0C.
  • Purify conjugates either by dialysis or size-exclusion chromatograph.

Storage:

  • Store at -20 0C; Desiccate; Avoid frequent thaw and freeze.
Documents
  • SDS
  • DataSheet

Related Products
PG1-DB-5k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-2k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-10k , mPEG-DBCO, PEG Dibenzylcyclooctyne
PG1-DB-1k , mPEG-DBCO, PEG Dibenzylcyclooctyne

Tags: DBCO PEG,

NH2-PEG2-C6-Cl

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

NH2-PEG2-C6-Cl  纯度: ≥95.0%

NH2-PEG2-C6-Cl 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

NH2-PEG2-C6-Cl

NH2-PEG2-C6-Cl Chemical Structure

CAS No. : 744203-60-9

规格 价格 是否有货 数量
50 mg ¥1350 In-stock
100 mg ¥1980 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

NH2-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

223.74

Formula

C10H22ClNO2

CAS 号

744203-60-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (446.95 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.4695 mL 22.3474 mL 44.6947 mL
5 mM 0.8939 mL 4.4695 mL 8.9389 mL
10 mM 0.4469 mL 2.2347 mL 4.4695 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.17 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (11.17 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.17 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (11.17 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.17 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (11.17 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Cl-PEG2-acid

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Cl-PEG2-acid 

Cl-PEG2-acid 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Cl-PEG2-acid

Cl-PEG2-acid Chemical Structure

CAS No. : 170304-76-4

规格 价格 是否有货
100 mg ¥2000 询问价格 & 货期
250 mg ¥3200 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Cl-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

182.60

Formula

C6H11ClO4

CAS 号

170304-76-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (547.65 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.4765 mL 27.3823 mL 54.7645 mL
5 mM 1.0953 mL 5.4765 mL 10.9529 mL
10 mM 0.5476 mL 2.7382 mL 5.4765 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (13.69 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (13.69 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (13.69 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (13.69 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (13.69 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (13.69 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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