Pep-1 (uncapped)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Pep-1 (uncapped) 

Pep-1 (uncapped) 是一种可透过细胞的多肽。

Pep-1 (uncapped)

Pep-1 (uncapped) Chemical Structure

CAS No. : 395069-86-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pep-1 (uncapped) is a cell-penetrating peptide.

分子量

2848.22

Formula

C136H195N35O33

CAS 号

395069-86-0

Sequence

Lys-Glu-Thr-Trp-Trp-Glu-Thr-Trp-Trp-Thr-Glu-Trp-Ser-Gln-Pro-Lys-Lys-Lys-Arg-Lys-Val

Sequence Shortening

KETWWETWWTEWSQPKKKRKV

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献
  • [1]. Almarwani B, et al. Vesicles mimicking normal and cancer cell membranes exhibit differential responses to the cell-penetrating peptide Pep-1. Biochim Biophys Acta Biomembr. 2018 Jun;1860(6):1394-1402.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Pep2-8

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Pep2-8  纯度: 99.01%

Pep2-8 是 PCSK9 抑制剂,其 KD 值为 0.7 μM,IC50 值为1.4 μM。

Pep2-8

Pep2-8 Chemical Structure

CAS No. : 1541011-97-5

规格 价格 是否有货 数量
5 mg ¥3000 In-stock
10 mg ¥5000 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

生物活性

Pep2-8 is a PCSK9 inhibitor with a binding KD of 0.7 μM and an IC50 of 1.4 μM[1].

体外研究
(In Vitro)

Pep2-8 binds to C-terminally truncated PCSK9[1].
Pep2-8 restored LDL uptake of PCSK9-treated HepG2 cells to about 90% of control activity at a concentration of 50 μM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2 cell.
Concentration: 15 μg/mL.
Incubation Time: 4 h.
Result: Inhibited PCSK9 activity.

分子量

1715.85

Formula

C83H110N16O24

CAS 号

1541011-97-5

Sequence Shortening

Ac-TVFTSWEEYLDWV-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Yingnan Zhang, et al. Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J Biol Chem. 2014 Jan 10;289(2):942-55.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

多肽定制Pep 4A 编码

上海金畔生物科技有限公司可以定制不同序列多肽,可以访问官网了解更多产品信息。

名称 Pep 4A
编码
别名 Pep 4A
纯度 80%,90%,95%,98%,99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列(单字母缩写) GSVVIVGRIILSGR-NH2
序列(三字母缩写) Gly-Ser-Val-Val-Ile-Val-Gly-Arg-Ile-Ile-Leu-Ser-Gly-Arg-NH2
基本描述
溶解度
分子量 1424.77
化学式 C63H117N21O16
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Pep 4A          编码
Figures Pep 4A          编码
Reference
C端
N端
化学桥

多肽定制Pep 4AK 编码

上海金畔生物科技有限公司可以定制不同序列多肽,可以访问官网了解更多产品信息。

名称 Pep 4AK
编码
别名 Pep 4AK
纯度 80%,90%,95%,98%,99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列(单字母缩写) KKKGSVVIVGRIILSGR-NH2
序列(三字母缩写) Lys-Lys-Lys-Gly-Ser-Val-Val-Ile-Val-Gly-Arg-Ile-Ile-Leu-Ser-Gly-Arg-NH2
基本描述
溶解度
分子量 1809.29
化学式 C81H153N27O19
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Pep 4AK          编码
Figures Pep 4AK          编码
Reference
C端
N端
化学桥

多肽定制Pep-1 编码

上海金畔生物科技有限公司可以定制不同序列多肽,可以访问官网了解更多产品信息。

名称 Pep-1
编码
别名 Pep-1
纯度 80%,90%,95%,98%,99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列(单字母缩写) KETWWETWWTEWSQPKKKRKV
序列(三字母缩写) H-Lys-Glu-Thr-Trp-Trp-Glu-Thr-Trp-Trp-Thr-Glu-Trp-Ser-Gln-Pro-Lys-Lys-Lys-Arg-Lys-Val-OH (trifluoroacetate salt)
基本描述 This is the most characterized fragment of the HIV transactivator protein (TAT). This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis, and has been proven to promote the entry of nucleic acids into several cell types
溶解度
分子量 2848.3
化学式 C136H195N35O33
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Pep-1          编码
Figures Pep-1          编码
Reference M. C. Morris, et al., Nature Pub. Group, Vol 19, pg 1173 (2001)
C端
N端
化学桥

多肽定制Pep11099 编码

上海金畔生物科技有限公司可以定制不同序列多肽,可以访问官网了解更多产品信息。

名称 Pep11099
编码
别名 Pep11099
纯度 80%,90%,95%,98%,99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列(单字母缩写) Pep11001
序列(三字母缩写)
基本描述
溶解度
分子量 0
化学式
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Pep11099          编码
Figures Pep11099          编码
Reference
C端
N端
化学桥

多肽定制Pep-1L-NOTA 编码

上海金畔生物科技有限公司可以定制不同序列多肽,可以访问官网了解更多产品信息。

名称 Pep-1L-NOTA
编码
别名 Pep-1L-NOTA
纯度 80%,90%,95%,98%,99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列(单字母缩写) ACGEMGWVRCGGGS-C6-K-K(NOTA)-NH2(Reduced Cys-H)
序列(三字母缩写) H-Ala-Cys-Gly-Glu-Met-Gly-Trp-Val-Arg-Cys-Gly-Gly-Gly-Ser-C6-Lys-Lys(NOTA)-NH2?(trifluoroacetate salt)(Reduced Cys-H)
基本描述 This peptide is the C-terminally amidated octapeptide found in bovine brain and adrenal tissue, corresponds to residues 206-213 of the bovine proenkephalin precursor. It is also related in sequence to the bovine adrenal medulla peptides. So far, it is the only endogenous opioid peptide with high affinity for 碌 opioid receptors.
溶解度
分子量 2023.36
化学式 C84H139N27O25S3
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Pep-1L-NOTA          编码
Figures Pep-1L-NOTA          编码
Reference Sai, Kiran Kumar Solingapuram, et al. “Peptide-based PET imaging of the tumor restricted IL13RA2 biomarker.” Oncotarget 5 (2017).
C端
N端
化学桥 (Reduced Cys-H)