上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Piclidenoson (Synonyms: IB-MECA; CF-101) 纯度: 99.32%
Piclidenoson (IB-MECA) 是一种首创的,具有口服活性的,选择性的腺苷 A3 受体 (A3AR) 激动剂。Piclidenoson 在不同类型的癌细胞如黑色素瘤、白血病中表现出抗增殖和诱导凋亡 (apoptosis) 的作用。Piclidenoson 可用于自身免疫性炎症疾病和 COVID-19 的研究。
Piclidenoson Chemical Structure
CAS No. : 152918-18-8
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1459 | In-stock | |
2 mg | ¥800 | In-stock | |
5 mg | ¥1300 | In-stock | |
10 mg | ¥2200 | In-stock | |
25 mg | ¥4400 | In-stock | |
50 mg | ¥7400 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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Piclidenoson 相关产品
•相关化合物库:
- Drug Repurposing Compound Library Plus
- Clinical Compound Library Plus
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- GPCR/G Protein Compound Library
- Immunology/Inflammation Compound Library
- Anti-Cancer Compound Library
- Clinical Compound Library
- Small Molecule Immuno-Oncology Compound Library
- Drug Repurposing Compound Library
- Anti-COVID-19 Compound Library
- Neurotransmitter Receptor Compound Library
- Anti-Blood Cancer Compound Library
- Rare Diseases Drug Library
生物活性 |
Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19[1][2][3][4]. |
IC50 & Target |
A3AR[2] |
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体外研究 (In Vitro) |
Piclidenoson is able to inhibit Forskolin (HY-15371)-stimulated cAMP levels with EC50s of 0.82 μM and 1.2 μM in OVCAR-3 cells and Caov-4 cells, respectively[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
Apoptosis Analysis[2]
Western Blot Analysis[2]
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体内研究 (In Vivo) |
Piclidenoson (105 μg/kg; i.p.) enhances survival of γ-irradiated mice[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
510.29 |
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Formula |
C18H19IN6O4 |
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CAS 号 |
152918-18-8 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 45 mg/mL (88.19 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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