Pimelic Diphenylamide 106 (analog)(Synonyms: RGFA-8 analog; TC-H 106 analog)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Pimelic Diphenylamide 106 (analog) (Synonyms: RGFA-8 analog; TC-H 106 analog) 纯度: 98.20%

Pimelic Diphenylamide 106 类似物是Pimelic Diphenylamide 106的类似物,活性未知。

Pimelic Diphenylamide 106 (analog)(Synonyms: RGFA-8 analog;  TC-H 106 analog)

Pimelic Diphenylamide 106 (analog) Chemical Structure

CAS No. : 2070015-24-4

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥792 In-stock
5 mg ¥720 In-stock
10 mg ¥1200 In-stock
50 mg ¥5000 In-stock
100 mg ¥8000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Pimelic Diphenylamide 106 (analog) 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library
  • Peptidomimetic Library

生物活性

Pimelic Diphenylamide 106 analog is an analog of Pimelic Diphenylamide 106 with unknown biological activity.

分子量

353.46

Formula

C21H27N3O2

CAS 号

2070015-24-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 30 mg/mL (84.88 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8292 mL 14.1459 mL 28.2917 mL
5 mM 0.5658 mL 2.8292 mL 5.6583 mL
10 mM 0.2829 mL 1.4146 mL 2.8292 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Chou CJ, et al. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19;283(51):35402-35409.

    [2]. Xu C, et al. Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing. Chem Biol. 2009 Sep 25;16(9):980-989.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Pimelic Diphenylamide 106 (analog)(Synonyms: RGFA-8 analog; TC-H 106 analog)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Pimelic Diphenylamide 106 (analog) (Synonyms: RGFA-8 analog; TC-H 106 analog) 纯度: 98.20%

Pimelic Diphenylamide 106 类似物是Pimelic Diphenylamide 106的类似物,活性未知。

Pimelic Diphenylamide 106 (analog)(Synonyms: RGFA-8 analog;  TC-H 106 analog)

Pimelic Diphenylamide 106 (analog) Chemical Structure

CAS No. : 2070015-24-4

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥792 In-stock
5 mg ¥720 In-stock
10 mg ¥1200 In-stock
50 mg ¥5000 In-stock
100 mg ¥8000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Pimelic Diphenylamide 106 (analog) 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library
  • Peptidomimetic Library

生物活性

Pimelic Diphenylamide 106 analog is an analog of Pimelic Diphenylamide 106 with unknown biological activity.

分子量

353.46

Formula

C21H27N3O2

CAS 号

2070015-24-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 30 mg/mL (84.88 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8292 mL 14.1459 mL 28.2917 mL
5 mM 0.5658 mL 2.8292 mL 5.6583 mL
10 mM 0.2829 mL 1.4146 mL 2.8292 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Chou CJ, et al. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19;283(51):35402-35409.

    [2]. Xu C, et al. Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing. Chem Biol. 2009 Sep 25;16(9):980-989.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Pimelic Diphenylamide 106 (analog)(Synonyms: RGFA-8 analog; TC-H 106 analog)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Pimelic Diphenylamide 106 (analog) (Synonyms: RGFA-8 analog; TC-H 106 analog) 纯度: 98.20%

Pimelic Diphenylamide 106 类似物是Pimelic Diphenylamide 106的类似物,活性未知。

Pimelic Diphenylamide 106 (analog)(Synonyms: RGFA-8 analog;  TC-H 106 analog)

Pimelic Diphenylamide 106 (analog) Chemical Structure

CAS No. : 2070015-24-4

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥792 In-stock
5 mg ¥720 In-stock
10 mg ¥1200 In-stock
50 mg ¥5000 In-stock
100 mg ¥8000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Pimelic Diphenylamide 106 (analog) 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library
  • Peptidomimetic Library

生物活性

Pimelic Diphenylamide 106 analog is an analog of Pimelic Diphenylamide 106 with unknown biological activity.

分子量

353.46

Formula

C21H27N3O2

CAS 号

2070015-24-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 30 mg/mL (84.88 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8292 mL 14.1459 mL 28.2917 mL
5 mM 0.5658 mL 2.8292 mL 5.6583 mL
10 mM 0.2829 mL 1.4146 mL 2.8292 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Chou CJ, et al. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19;283(51):35402-35409.

    [2]. Xu C, et al. Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing. Chem Biol. 2009 Sep 25;16(9):980-989.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Pimelic Diphenylamide 106(Synonyms: RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Pimelic Diphenylamide 106 (Synonyms: RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII) 纯度: 98.39%

Pimelic Diphenylamide 106 是一种缓慢的, 结合紧密的I类HDAC抑制剂 (抑制HDAC1, 2和3, IC50值分别150 nM, 760nM, 和370 nM), 对II类HDAC没有活性。

Pimelic Diphenylamide 106(Synonyms: RGFA-8;  TC-H 106;  Histone Deacetylase Inhibitor VII)

Pimelic Diphenylamide 106 Chemical Structure

CAS No. : 937039-45-7

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥550 In-stock
5 mg ¥500 In-stock
10 mg ¥850 In-stock
25 mg ¥1400 In-stock
50 mg ¥2400 In-stock
100 mg ¥4400 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Pimelic Diphenylamide 106 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Cell Cycle/DNA Damage Compound Library
  • Epigenetics Compound Library
  • Histone Modification Research Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Reprogramming Compound Library
  • Oxygen Sensing Compound Library
  • Anti-Breast Cancer Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Anti-Liver Cancer Compound Library

生物活性

Pimelic Diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (HDAC 1, 2, and 3, with IC50 values of 150 nM , 760nM, and 370 nM, respectively), demonstrating no activity against class II HDACs. IC50 value: 150 nM (HDAC1), 370 nM (HDAC3), 760nM(HDAC2) Target: HDAC in vitro: Pimelic Diphenylamide 106 has preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1. Pimelic Diphenylamide 106 exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM after a 3-h preincubation with HDAC8.

IC50 & Target

HDAC1

150 nM (IC50)

HDAC3

370 nM (IC50)

HDAC2

760 nM (IC50)

HDAC8

5000 nM (IC50)

分子量

339.43

Formula

C20H25N3O2

CAS 号

937039-45-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 125 mg/mL (368.26 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9461 mL 14.7306 mL 29.4612 mL
5 mM 0.5892 mL 2.9461 mL 5.8922 mL
10 mM 0.2946 mL 1.4731 mL 2.9461 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.55 mg/mL (1.62 mM); Clear solution

    此方案可获得 ≥ 0.55 mg/mL (1.62 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 5.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.55 mg/mL (1.62 mM); Clear solution

    此方案可获得 ≥ 0.55 mg/mL (1.62 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 5.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 0.55 mg/mL (1.62 mM); Clear solution

    此方案可获得 ≥ 0.55 mg/mL (1.62 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 5.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Chou CJ, et al. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19;283(51):35402-35409.

    [2]. Xu C, et al. Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing. Chem Biol. 2009 Sep 25;16(9):980-989.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务