Dromostanolone propionate (Drostanolone propionate) is a compound has antitumor activity against breast carcinoma[1]. Dromostanolone propionate inhibits the uptake of oestradiol-17ß by the tumour but has no apparent effect on the uptake by normal breast tissue [2]. Dromostanolone propionate implant pellet produces weight gains in animals and suppresses estrus in female animals[3].
分子量
360.53
Formula
C23H36O3
CAS 号
521-12-0
中文名称
屈他雄酮丙酸酯
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Takeuchi S, et al. Clinical experience with dromostanolone propionate (NSC-12198) in breast carcinoma. Saishin Igaku. 1967 May;22(5):1049-54.
[2]. N.Deshpande, et al. Accumulation of tritiated oestradiol by human breast tissue. Steroids, 1967 Sep;10(3), 219–232.
[3]. Brian H. Vickery . Dromostanolone propionate implant pellet useful for producing weight gains in animals and suppressing estrus in female animals. US3991750A.
Methyl propionate-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC50 & Target
PEGs
Alkyl/ether
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
632.74
Formula
C28H56O15
CAS 号
1239588-11-4
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Camptothecin-20(S)-O-propionate (CZ48) 是喜树碱 (CPT) 的类似物，是强效的抗肿瘤化合物。Camptothecin-20(S)-O-propionate (CZ48) 是拓扑异构酶 I (topoisomerase-Ι) 的抑制剂。
Camptothecin-20(S)-O-propionate Chemical Structure
CAS No. : 194414-69-2
规格
价格
是否有货
数量
10 mM * 1 mL in DMSO
￥3850
In-stock
5 mg
￥3500
In-stock
10 mg
￥5800
In-stock
50 mg
￥16500
In-stock
100 mg
￥25500
In-stock
200 mg
询价
500 mg
询价
* Please select Quantity before adding items.
Camptothecin-20(S)-O-propionate 相关产品
•相关化合物库:
Clinical Compound Library Plus
Bioactive Compound Library Plus
Cell Cycle/DNA Damage Compound Library
Anti-Cancer Compound Library
Clinical Compound Library
Anti-Aging Compound Library
Anti-Lung Cancer Compound Library
生物活性
Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3].
体内研究 (In Vivo)
Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice[3].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
A tumor xenograft growing in a nude mouse (size, ∼1 cm3)[3].
Dosage:
100-1000 mg/kg/day.
Administration:
Oral gavage, for 2, 4 and 6 days, respectively.
Result:
Exhibited anti-tumor effect.
Clinical Trial
分子量
404.42
Formula
C23H20N2O5
CAS 号
194414-69-2
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9.
[2]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9.
[3]. Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1(2):202-206.
N-Succinimidyl 3-(Bromoacetamido)propionate Chemical Structure
CAS No. : 57159-62-3
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
IC50 & Target
PEGs
Alkyl/ether
Cleavable
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
307.10
Formula
C9H11BrN2O5
CAS 号
57159-62-3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
[2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
N-Succinimidyl 3-(Bromoacetamido)propionate Chemical Structure
CAS No. : 57159-62-3
规格
是否有货
100 mg
询价
250 mg
询价
500 mg
询价
* Please select Quantity before adding items.
生物活性
N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
IC50 & Target
PEGs
Alkyl/ether
Cleavable
体外研究 (In Vitro)
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
307.10
Formula
C9H11BrN2O5
CAS 号
57159-62-3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
[2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
