Roslin 2 bromide(Synonyms: Benzylhexamethylenetetramine bromide)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Roslin 2 bromide (Synonyms: Benzylhexamethylenetetramine bromide)

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) 是一种具有抗癌作用的 p53 再激活剂。Roslin 2 bromide 结合 FAK,破坏 FAK 和 p53 的结合。

Roslin 2 bromide(Synonyms: Benzylhexamethylenetetramine bromide)

Roslin 2 bromide Chemical Structure

CAS No. : 29574-21-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK, disrupts the binding of FAK and p53[1].

体外研究
(In Vitro)

Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

311.22

Formula

C13H19BrN4

CAS 号

29574-21-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Vita M Golubovskaya, et al. Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer. 2013 Jul 11;13:342.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Roslin 2 bromide(Synonyms: Benzylhexamethylenetetramine bromide)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Roslin 2 bromide (Synonyms: Benzylhexamethylenetetramine bromide)

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) 是一种具有抗癌作用的 p53 再激活剂。Roslin 2 bromide 结合 FAK,破坏 FAK 和 p53 的结合。

Roslin 2 bromide(Synonyms: Benzylhexamethylenetetramine bromide)

Roslin 2 bromide Chemical Structure

CAS No. : 29574-21-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK, disrupts the binding of FAK and p53[1].

体外研究
(In Vitro)

Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

311.22

Formula

C13H19BrN4

CAS 号

29574-21-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Vita M Golubovskaya, et al. Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer. 2013 Jul 11;13:342.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Roslin 2 bromide(Synonyms: Benzylhexamethylenetetramine bromide)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Roslin 2 bromide (Synonyms: Benzylhexamethylenetetramine bromide)

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) 是一种具有抗癌作用的 p53 再激活剂。Roslin 2 bromide 结合 FAK,破坏 FAK 和 p53 的结合。

Roslin 2 bromide(Synonyms: Benzylhexamethylenetetramine bromide)

Roslin 2 bromide Chemical Structure

CAS No. : 29574-21-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK, disrupts the binding of FAK and p53[1].

体外研究
(In Vitro)

Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53+/+ but not in HCT116 p53-/- xenografts in vivo[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

311.22

Formula

C13H19BrN4

CAS 号

29574-21-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Vita M Golubovskaya, et al. Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. BMC Cancer. 2013 Jul 11;13:342.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务