标签归档：succinic

Succinic anhydride-d4

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Succinic anhydride-d4 

Succinic anhydride-d4 是 Succinic anhydride 的氘代物。Succinic anhydride 是一种环酐和不可降解 (non-cleavable) 的 ADC linker，详细信息可参考专利 WO2009064913A1。Succinic anhydride 与专利中的化合物 4 反应，可将前药连接到靶向多肽的胺或羟基 1。

Succinic anhydride-d4

Succinic anhydride-d4 Chemical Structure

CAS No. : 14341-86-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Succinic anhydride-d4 is the deuterium labeled Succinic anhydride. Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

104.10

Formula

C4D4O3
CAS 号

14341-86-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Succinic anhydride

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Succinic anhydride  纯度: ≥95.0%

Succinic anhydride 是一种环酐和不可降解 (non-cleavable) 的 ADC linker，详细信息可参考专利 WO2009064913A1。Succinic anhydride 与专利中的化合物 4 反应，可将前药连接到靶向多肽的胺或羟基 1。

Succinic anhydride

Succinic anhydride Chemical Structure

CAS No. : 108-30-5

规格 价格 是否有货 数量
100 mg ￥500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Succinic anhydride 相关产品

•相关化合物库:

  • Fragment Library

生物活性

Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide[1].

IC50 & Target[1]

Non-cleavable

 

分子量

100.07

Formula

C4H4O3
CAS 号

108-30-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (999.30 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 9.9930 mL 49.9650 mL 99.9300 mL
5 mM 1.9986 mL 9.9930 mL 19.9860 mL
10 mM 0.9993 mL 4.9965 mL 9.9930 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (24.98 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (24.98 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (24.98 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (24.98 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (24.98 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (24.98 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PEG succinic acid, mPEG-OCOCH2CH2COOH Cat. No. PG1-SA-5k-1 5000 Da 1 g修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG succinic acid, mPEG-OCOCH2CH2COOH

Cat. No. PG1-SA-5k-1
Specification 5000 Da
Unit Size 1 g
Price $385.00

Qty Add to Cart

Description:

Carboxylic acid functionalized methoxyl polyethylene glycol, PEG acid (mPEG-COOH) is a mono reactive PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccate. Protect from light. Avoid frequent thaw and freeze.

*Note: Structure showed here mainly represents the functional groups derived from PEG. Exact linker may not show. Contact us if you have any concern about the linker.

Documents
  • SDS
  • DataSheet

PEG succinic acid, mPEG-OCOCH2CH2COOH Cat. No. PG1-SA-5k-2 5000 Da 5 g修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG succinic acid, mPEG-OCOCH2CH2COOH

Cat. No. PG1-SA-5k-2
Specification 5000 Da
Unit Size 5 g
Price $885.00

Qty Add to Cart

Description:

Succinic acid functionalized methoxyl polyethylene glycol, PEG acid (mPEG-COOH) is a mono reactive PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Form: Solid
  • Color: White
  • Solubility: Soluble in water and chloroform
  • Purity: >95%
  • PDI: <1.10

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.

References:

Click here to see hundreds of publications from Nanocs PEGs.

Documents
  • SDS
  • DataSheet

PEG succinic acid, mPEG-OCOCH2CH2COOH Cat. No. PG1-SA-2k 2000 Da 1 g修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG succinic acid, mPEG-OCOCH2CH2COOH

Cat. No. PG1-SA-2k
Specification 2000 Da
Unit Size 1 g
Price $325.00

Qty Add to Cart

Description:

Carboxylic acid functionalized methoxyl polyethylene glycol, PEG acid (mPEG-COOH) is a mono reactive PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, dessiccate. Protect from light. Avoid frequent thaw and freeze.

*Note: Structure showed here mainly represents the functional groups derived from PEG. Exact linker may not show. Contact us if you have any concern about the linker.

Documents
  • SDS
  • DataSheet

PEG succinic acid, mPEG-OCOCH2CH2COOH Cat. No. PG1-SA-1k 1000 Da 1 g修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG succinic acid, mPEG-OCOCH2CH2COOH

Cat. No. PG1-SA-1k
Specification 1000 Da
Unit Size 1 g
Price $325.00

Qty Add to Cart

Description:

Carboxylic acid functionalized methoxyl polyethylene glycol, PEG acid (mPEG-COOH) is a mono reactive PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Form: Solid
  • Color: White
  • Solubility: Soluble in water and chloroform
  • Functional group: Acid (-COOH)
  • Purity: >95%
  • PDI: <1.10

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.

References:

Click here to see hundreds of publications from Nanocs PEGs.

Documents
  • SDS
  • DataSheet

PEG succinic acid, mPEG-OCOCH2CH2COOH Cat. No. PG1-SA-10k 10000 Da 100 mg修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

PEG succinic acid, mPEG-OCOCH2CH2COOH

Cat. No. PG1-SA-10k
Specification 10000 Da
Unit Size 100 mg
Price $385.00

Qty Add to Cart

Description:

Succinic acid functionalized methoxyl polyethylene glycol, PEG acid (mPEG-COOH) is a mono reactive PEG derivative that can be used to modify proteins, peptides and other materials via amino or other acid reactive chemical groups. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Physical Properties:

  • Form: Solid
  • Color: White
  • Solubility: Soluble in water and chloroform
  • Functional group: succinic acid
  • Purity: >95%
  • PDI: <1.10

Storage Conditions:

  • Store at -20 0C. Avoid frequent thaw and freeze.

References:

Click here to see hundreds of publications from Nanocs PEGs.

Documents
  • SDS
  • DataSheet

Methoxy PEG succinic acid NHS Cat. No. PG1-SSA-5k 5000 Da 1 g修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Methoxy PEG succinic acid NHS

Cat. No. PG1-SSA-5k Methoxy PEG succinic acid NHS Cat. No. PG1-SSA-5k 5000 Da 1 g
Specification 5000 Da
Unit Size 1 g
Price $325.00

Qty Add to Cart

Description:

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol (PEG-NHS) is an amino (-NH2) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with their available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl carbonate (SC) functionalized mPEG-NHS offers superior reactivity and higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, desiccate. NHS PEG tends to hydrolyze from moisture. Avoid frequent thaw and frozen.

Reaction Procedures:

Generally, a 10 to 50-fold molar excess of NHS PEG over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

  • Conjugation buffer: Sodium bicarbonate 100 mM buffer, pH 8.5 or other amine-free buffer at pH 7-8.5.
  • PEG NHS stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add NHS PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG NHS needed for optimal conjugation; Allow mixture agitates at room temperature for 30~60 min at room temperature or 2 hours at 4 0C. Conjugates can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

Methoxy PEG succinic acid NHS Cat. No. PG1-SSA-2k 2000 Da 1 g修饰性聚乙二醇

发表于由

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Methoxy PEG succinic acid NHS

Cat. No. PG1-SSA-2k Methoxy PEG succinic acid NHS Cat. No. PG1-SSA-2k 2000 Da 1 g
Specification 2000 Da
Unit Size 1 g
Price $325.00

Qty Add to Cart

Description:

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol (PEG-NHS) is an amino (-NH2) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with their available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl carbonate (SC) functionalized mPEG-NHS offers superior reactivity and higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, desiccate. NHS PEG tends to hydrolyze from moisture. Avoid frequent thaw and frozen.

Reaction Procedures:

Generally, a 10 to 50-fold molar excess of NHS PEG over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

  • Conjugation buffer: Sodium bicarbonate 100 mM buffer, pH 8.5 or other amine-free buffer at pH 7-8.5.
  • PEG NHS stock solution: 100 mg in 1 mL conjugation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjugation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add NHS PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG NHS needed for optimal conjugation; Allow mixture agitates at room temperature for 30~60 min at room temperature or 2 hours at 4 0C. Conjugates can be purified either by size exclusion chromatography or dialysis.

Documents
  • SDS
  • DataSheet

甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺, ,Methoxy PEG succinic acid NHS,

发表于由

甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺

MW 5000 Da

有货

甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺, ,Methoxy PEG succinic acid NHS,

品牌：Jinpan
Methoxy PEG succinic acid NHS

MSDS

质检证书(CoA)

相似产品

货号 (SKU) 包装规格 是否现货 价格 数量
M163958-250mg 250mg 期货 甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺, ,Methoxy PEG succinic acid NHS,  
M163958-1g 1g 期货 甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺, ,Methoxy PEG succinic acid NHS,  
M163958-5g 5g 期货 甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺, ,Methoxy PEG succinic acid NHS,  

基本信息

产品名称 甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺
英文名称 Methoxy PEG succinic acid NHS
规格或纯度 MW 5000 Da
运输条件 超低温冰袋运输
生化机理

Generally, a 10 to 50-fold molar excess of NHS PEG over the amount of amine-containing material results in sufficient conjμgation.

Materials Required:

  • Conjμgation buffer: Sodium bicarbonate 100 mM buffer, pH 8.5 or other amine-free buffer at pH 7-8.5.
  • PEG NHS stock solution: 100 mg in 1 mL conjμgation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjμgation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add NHS PEG stock solution to the targeted conjμgation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG NHS needed for optimal conjμgation; Allow mixture agitates at room temperature for 30~60 min at room temperature or 2 hours at 4 0C. Conjμgates can be purified either by size exclusion chromatography or dialysis.

一般描述

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol (PEG-NHS) is an amino (-NH2) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with their available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl carbonate (SC) functionalized mPEG-NHS offers superior reactivity and higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol (PEG-NHS) is an amino (-NH2) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with their available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl carbonate (SC) functionalized mPEG-NHS offers superior reactivity and higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

相关属性

敏感性 对湿度敏感
溶解性 Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;
储存温度 -20°C储存,充氩
品牌 Jinpan

甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺, ,Methoxy PEG succinic acid NHS,

发表于由

甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺

MW 2000 Da

有货

甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺, ,Methoxy PEG succinic acid NHS,

品牌：Jinpan
Methoxy PEG succinic acid NHS

MSDS

质检证书(CoA)

相似产品

货号 (SKU) 包装规格 是否现货 价格 数量
M163957-1g 1g 现货 甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺, ,Methoxy PEG succinic acid NHS,  

基本信息

产品名称 甲氧基 PEG 琥珀酸 N-羟基琥珀酰亚胺
英文名称 Methoxy PEG succinic acid NHS
规格或纯度 MW 2000 Da
运输条件 超低温冰袋运输
生化机理

Generally, a 10 to 50-fold molar excess of NHS PEG over the amount of amine-containing material results in sufficient conjμgation.

Materials Required:

  • Conjμgation buffer: Sodium bicarbonate 100 mM buffer, pH 8.5 or other amine-free buffer at pH 7-8.5.
  • PEG NHS stock solution: 100 mg in 1 mL conjμgation buffer.
  • Washing solution: Distilled water or any aqueous buffer.

Reaction Steps:

Dissolve targeted materials in conjμgation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add NHS PEG stock solution to the targeted conjμgation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of PEG NHS needed for optimal conjμgation; Allow mixture agitates at room temperature for 30~60 min at room temperature or 2 hours at 4 0C. Conjμgates can be purified either by size exclusion chromatography or dialysis.

一般描述

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol (PEG-NHS) is an amino (-NH2) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with their available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl carbonate (SC) functionalized mPEG-NHS offers superior reactivity and higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol (PEG-NHS) is an amino (-NH2) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with their available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl carbonate (SC) functionalized mPEG-NHS offers superior reactivity and higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

相关属性

溶解性 Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;
储存温度 -20°C储存
品牌 Jinpan
备注 卖完停产，不再备货