Ivacaftor-d9(Synonyms: VX-770-d9)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ivacaftor-d9 (Synonyms: VX-770-d9)

Ivacaftor-D9 (CTP-656) 是一种有效的 CFTR 调节剂,在 G551D/F508del HBE 细胞中 CFTR 增强的 EC50 值为 255 nM。Ivacaftor- d9 作为一种具有口服活性和改良的 Ivacaftor 氘化物用于囊性纤维化研究。

Ivacaftor-d9(Synonyms: VX-770-d9)

Ivacaftor-d9 Chemical Structure

CAS No. : 1413431-07-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ivacaftor-D9 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

体内研究
(In Vivo)

In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.
CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg).

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

401.55

Formula

C24H19D9N2O3

CAS 号

1413431-07-8

中文名称

依伐卡托 D9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

    [2]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

3′-Deoxyuridine(Synonyms: 3-脱氧尿苷)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

3′-Deoxyuridine (Synonyms: 3-脱氧尿苷) 纯度: 95.74%

3′-Deoxyuridine 是一种潜在的抗癌和抗病毒药。3′-Deoxyuridine 抑制牛腹泻病毒 (BVDV) 的产生。

3′-Deoxyuridine(Synonyms: 3-脱氧尿苷)

3′-Deoxyuridine Chemical Structure

CAS No. : 7057-27-4

规格 价格 是否有货 数量
50 mg ¥2900 In-stock
100 mg ¥4500 In-stock
250 mg ¥8600 In-stock
500 mg   询价  
1 g   询价  

* Please select Quantity before adding items.

3′-Deoxyuridine 相关产品

相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Like Compound Library
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Anti-Cancer Compound Library
  • Covalent Screening Library
  • Nucleotide Compound Library

生物活性

3′-Deoxyuridine is a potential anticancer and antiviral agent. 3′-deoxyuridine inhibits bovine diarrhoea virus (BVDV) production[1].

分子量

228.20

Formula

C9H12N2O5

CAS 号

7057-27-4

中文名称

3-脱氧尿苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 50 mg/mL (219.11 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.3821 mL 21.9106 mL 43.8212 mL
5 mM 0.8764 mL 4.3821 mL 8.7642 mL
10 mM 0.4382 mL 2.1911 mL 4.3821 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.96 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.96 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.96 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.96 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.96 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.96 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Lin TS, et al. Synthesis and anticancer activity of various 3′-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine. J Med Chem. 1991;34(2):693-701.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Ivacaftor-d9(Synonyms: VX-770-d9)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ivacaftor-d9 (Synonyms: VX-770-d9)

Ivacaftor-D9 (CTP-656) 是一种有效的 CFTR 调节剂,在 G551D/F508del HBE 细胞中 CFTR 增强的 EC50 值为 255 nM。Ivacaftor- d9 作为一种具有口服活性和改良的 Ivacaftor 氘化物用于囊性纤维化研究。

Ivacaftor-d9(Synonyms: VX-770-d9)

Ivacaftor-d9 Chemical Structure

CAS No. : 1413431-07-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ivacaftor-D9 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

体内研究
(In Vivo)

In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.
CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg).

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

401.55

Formula

C24H19D9N2O3

CAS 号

1413431-07-8

中文名称

依伐卡托 D9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

    [2]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Ivacaftor-d9(Synonyms: VX-770-d9)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ivacaftor-d9 (Synonyms: VX-770-d9)

Ivacaftor-D9 (CTP-656) 是一种有效的 CFTR 调节剂,在 G551D/F508del HBE 细胞中 CFTR 增强的 EC50 值为 255 nM。Ivacaftor- d9 作为一种具有口服活性和改良的 Ivacaftor 氘化物用于囊性纤维化研究。

Ivacaftor-d9(Synonyms: VX-770-d9)

Ivacaftor-d9 Chemical Structure

CAS No. : 1413431-07-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ivacaftor-D9 (CTP-656) is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

体内研究
(In Vivo)

In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.
CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters Cmax, AUC0-24 hr, C24hr and t1/2 of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg).

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

401.55

Formula

C24H19D9N2O3

CAS 号

1413431-07-8

中文名称

依伐卡托 D9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

    [2]. Scott L Harbeson, et al. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development. J Pharmacol Exp Ther. 2017 Aug;362(2):359-367.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

3′-Deoxyuridine(Synonyms: 3-脱氧尿苷)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

3′-Deoxyuridine (Synonyms: 3-脱氧尿苷) 纯度: 95.74%

3′-Deoxyuridine 是一种潜在的抗癌和抗病毒药。3′-Deoxyuridine 抑制牛腹泻病毒 (BVDV) 的产生。

3′-Deoxyuridine(Synonyms: 3-脱氧尿苷)

3′-Deoxyuridine Chemical Structure

CAS No. : 7057-27-4

规格 价格 是否有货 数量
50 mg ¥2900 In-stock
100 mg ¥4500 In-stock
250 mg ¥8600 In-stock
500 mg   询价  
1 g   询价  

* Please select Quantity before adding items.

3′-Deoxyuridine 相关产品

相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Like Compound Library
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Anti-Cancer Compound Library
  • Covalent Screening Library
  • Nucleotide Compound Library

生物活性

3′-Deoxyuridine is a potential anticancer and antiviral agent. 3′-deoxyuridine inhibits bovine diarrhoea virus (BVDV) production[1].

分子量

228.20

Formula

C9H12N2O5

CAS 号

7057-27-4

中文名称

3-脱氧尿苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 50 mg/mL (219.11 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.3821 mL 21.9106 mL 43.8212 mL
5 mM 0.8764 mL 4.3821 mL 8.7642 mL
10 mM 0.4382 mL 2.1911 mL 4.3821 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.96 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.96 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.96 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.96 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.96 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.96 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Lin TS, et al. Synthesis and anticancer activity of various 3′-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine. J Med Chem. 1991;34(2):693-701.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

3′-Deoxyuridine(Synonyms: 3-脱氧尿苷)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

3′-Deoxyuridine (Synonyms: 3-脱氧尿苷) 纯度: 95.74%

3′-Deoxyuridine 是一种潜在的抗癌和抗病毒药。3′-Deoxyuridine 抑制牛腹泻病毒 (BVDV) 的产生。

3′-Deoxyuridine(Synonyms: 3-脱氧尿苷)

3′-Deoxyuridine Chemical Structure

CAS No. : 7057-27-4

规格 价格 是否有货 数量
50 mg ¥2900 In-stock
100 mg ¥4500 In-stock
250 mg ¥8600 In-stock
500 mg   询价  
1 g   询价  

* Please select Quantity before adding items.

3′-Deoxyuridine 相关产品

相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Like Compound Library
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Anti-Cancer Compound Library
  • Covalent Screening Library
  • Nucleotide Compound Library

生物活性

3′-Deoxyuridine is a potential anticancer and antiviral agent. 3′-deoxyuridine inhibits bovine diarrhoea virus (BVDV) production[1].

分子量

228.20

Formula

C9H12N2O5

CAS 号

7057-27-4

中文名称

3-脱氧尿苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 50 mg/mL (219.11 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.3821 mL 21.9106 mL 43.8212 mL
5 mM 0.8764 mL 4.3821 mL 8.7642 mL
10 mM 0.4382 mL 2.1911 mL 4.3821 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.96 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.96 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.96 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.96 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.96 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.96 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Lin TS, et al. Synthesis and anticancer activity of various 3′-deoxy pyrimidine nucleoside analogues and crystal structure of 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine. J Med Chem. 1991;34(2):693-701.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

(Z)-Semaxanib(Synonyms: (Z)-SU5416)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

(Z)-Semaxanib (Synonyms: (Z)-SU5416)

Z)-Semaxanib (compound (z)-1) 是一种有效的酪氨酸激酶抑制剂。(Z)-Semaxanib 对 TAMH 和 HepG2 细胞具有细胞毒性,IC50s 分别为 6.28 µM 和 8.17 µM。

(Z)-Semaxanib(Synonyms: (Z)-SU5416)

(Z)-Semaxanib Chemical Structure

CAS No. : 194413-58-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1].

分子量

238.28

Formula

C15H14N2O

CAS 号

194413-58-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ngai MH, So CL, Sullivan MB, Ho HK, Chai CL. Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones. ChemMedChem. 2016 Jan 5;11(1):72-80.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Moracin P(Synonyms: 桑辛素P)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Moracin P (Synonyms: 桑辛素P)

Moracin P 是从 Mori Cortex Radicis 中分离出来的 2-芳基苯并呋喃。Moracin P 对缺氧诱导因子 (HIF-1) 表现出强大的体外抑制活性。Moracin P 减少了氧葡萄糖剥夺 (OGD) 诱导的活性氧 (ROS) 的产生。Moracin P 具有神经保护和抗炎作用。

Moracin P(Synonyms: 桑辛素P)

Moracin P Chemical Structure

CAS No. : 102841-46-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin P reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects[1][2][3].

体外研究
(In Vitro)

Moracin P enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC50 value of 10.4 μM. Moracin P reduces ROS production in OGD-induced cell death (IC50 values of 1.9 μM). Consequently, reactive oxygen species (ROS) are overexpressed in OGD-induced cells and Moracin P reduces ROS induced by OGD in dosedependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

326.34

Formula

C19H18O5

CAS 号

102841-46-3

中文名称

桑辛素P

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34(8):1373-80.

    [2]. Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46(6):2386-96.

    [3]. Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Moracin O(Synonyms: 桑辛素O)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Moracin O (Synonyms: 桑辛素O)

Moracin O 是从 Mori Cortex Radicis 中分离出来的 2-芳基苯并呋喃。Moracin O 对缺氧诱导因子 (HIF-1) 表现出强大的体外抑制活性。Moracin O 减少了氧葡萄糖剥夺 (OGD) 诱导的活性氧 (ROS) 的产生。Moracin O 具有神经保护和抗炎作用。

Moracin O(Synonyms: 桑辛素O)

Moracin O Chemical Structure

CAS No. : 123702-97-6

规格 价格 是否有货
5 mg ¥3700 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Moracin O is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects[1][2][3].

体外研究
(In Vitro)

Moracin O enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC50 value of 12.6 μM. Moracin O reduces ROS production in OGD-induced cell death (IC50 value of 0.3 μM). Moracin O protects neuronal cell death against the oxidative stress induced by OGD[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

326.34

Formula

C19H18O5

CAS 号

123702-97-6

中文名称

桑辛素O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34(8):1373-80.

    [2]. Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46(6):2386-96.

    [3]. Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Nortrachelogenin(Synonyms: (-)-Wikstromol; (-)-Nortrachelogenin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Nortrachelogenin (Synonyms: (-)-Wikstromol; (-)-Nortrachelogenin)

Nortrachelogenin ((-)-Wikstromol) 可从 Partrinia scabiosaefolia 分离得到,可诱导 Candida albicans 的凋亡.

Nortrachelogenin(Synonyms: (-)-Wikstromol;  (-)-Nortrachelogenin)

Nortrachelogenin Chemical Structure

CAS No. : 34444-37-6

规格 价格 是否有货
1 mg ¥4500 询问价格 & 货期
5 mg ¥12800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Nortrachelogenin ((-)-Wikstromol) from Partrinia scabiosaefolia elicits an apoptotic response in Candida albicans[1].

分子量

374.38

Formula

C20H22O7

CAS 号

34444-37-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Heejeong Lee, et al. (-)-Nortrachelogenin from Partrinia scabiosaefolia elicits an apoptotic response in Candida albicans. FEMS Yeast Res. 2016 May;16(3):fow013.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Moracin P(Synonyms: 桑辛素P)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Moracin P (Synonyms: 桑辛素P)

Moracin P 是从 Mori Cortex Radicis 中分离出来的 2-芳基苯并呋喃。Moracin P 对缺氧诱导因子 (HIF-1) 表现出强大的体外抑制活性。Moracin P 减少了氧葡萄糖剥夺 (OGD) 诱导的活性氧 (ROS) 的产生。Moracin P 具有神经保护和抗炎作用。

Moracin P(Synonyms: 桑辛素P)

Moracin P Chemical Structure

CAS No. : 102841-46-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin P reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects[1][2][3].

体外研究
(In Vitro)

Moracin P enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC50 value of 10.4 μM. Moracin P reduces ROS production in OGD-induced cell death (IC50 values of 1.9 μM). Consequently, reactive oxygen species (ROS) are overexpressed in OGD-induced cells and Moracin P reduces ROS induced by OGD in dosedependent manner[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

326.34

Formula

C19H18O5

CAS 号

102841-46-3

中文名称

桑辛素P

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34(8):1373-80.

    [2]. Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46(6):2386-96.

    [3]. Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Moracin P(Synonyms: 桑辛素P)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Moracin P (Synonyms: 桑辛素P)

Moracin P 是从 Mori Cortex Radicis 中分离出来的 2-芳基苯并呋喃。Moracin P 对缺氧诱导因子 (HIF-1) 表现出强大的体外抑制活性。Moracin P 减少了氧葡萄糖剥夺 (OGD) 诱导的活性氧 (ROS) 的产生。Moracin P 具有神经保护和抗炎作用。

Moracin P(Synonyms: 桑辛素P)

Moracin P Chemical Structure

CAS No. : 102841-46-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin P reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects[1][2][3].

体外研究
(In Vitro)

Moracin P enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC50 value of 10.4 μM. Moracin P reduces ROS production in OGD-induced cell death (IC50 values of 1.9 μM). Consequently, reactive oxygen species (ROS) are overexpressed in OGD-induced cells and Moracin P reduces ROS induced by OGD in dosedependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

326.34

Formula

C19H18O5

CAS 号

102841-46-3

中文名称

桑辛素P

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34(8):1373-80.

    [2]. Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46(6):2386-96.

    [3]. Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Moracin O(Synonyms: 桑辛素O)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Moracin O (Synonyms: 桑辛素O)

Moracin O 是从 Mori Cortex Radicis 中分离出来的 2-芳基苯并呋喃。Moracin O 对缺氧诱导因子 (HIF-1) 表现出强大的体外抑制活性。Moracin O 减少了氧葡萄糖剥夺 (OGD) 诱导的活性氧 (ROS) 的产生。Moracin O 具有神经保护和抗炎作用。

Moracin O(Synonyms: 桑辛素O)

Moracin O Chemical Structure

CAS No. : 123702-97-6

规格 价格 是否有货
5 mg ¥3700 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Moracin O is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects[1][2][3].

体外研究
(In Vitro)

Moracin O enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC50 value of 12.6 μM. Moracin O reduces ROS production in OGD-induced cell death (IC50 value of 0.3 μM). Moracin O protects neuronal cell death against the oxidative stress induced by OGD[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

326.34

Formula

C19H18O5

CAS 号

123702-97-6

中文名称

桑辛素O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34(8):1373-80.

    [2]. Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46(6):2386-96.

    [3]. Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Moracin O(Synonyms: 桑辛素O)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Moracin O (Synonyms: 桑辛素O)

Moracin O 是从 Mori Cortex Radicis 中分离出来的 2-芳基苯并呋喃。Moracin O 对缺氧诱导因子 (HIF-1) 表现出强大的体外抑制活性。Moracin O 减少了氧葡萄糖剥夺 (OGD) 诱导的活性氧 (ROS) 的产生。Moracin O 具有神经保护和抗炎作用。

Moracin O(Synonyms: 桑辛素O)

Moracin O Chemical Structure

CAS No. : 123702-97-6

规格 价格 是否有货
5 mg ¥3700 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Moracin O is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects[1][2][3].

体外研究
(In Vitro)

Moracin O enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC50 value of 12.6 μM. Moracin O reduces ROS production in OGD-induced cell death (IC50 value of 0.3 μM). Moracin O protects neuronal cell death against the oxidative stress induced by OGD[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

326.34

Formula

C19H18O5

CAS 号

123702-97-6

中文名称

桑辛素O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34(8):1373-80.

    [2]. Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46(6):2386-96.

    [3]. Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Nortrachelogenin(Synonyms: (-)-Wikstromol; (-)-Nortrachelogenin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Nortrachelogenin (Synonyms: (-)-Wikstromol; (-)-Nortrachelogenin)

Nortrachelogenin ((-)-Wikstromol) 可从 Partrinia scabiosaefolia 分离得到,可诱导 Candida albicans 的凋亡.

Nortrachelogenin(Synonyms: (-)-Wikstromol;  (-)-Nortrachelogenin)

Nortrachelogenin Chemical Structure

CAS No. : 34444-37-6

规格 价格 是否有货
1 mg ¥4500 询问价格 & 货期
5 mg ¥12800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Nortrachelogenin ((-)-Wikstromol) from Partrinia scabiosaefolia elicits an apoptotic response in Candida albicans[1].

分子量

374.38

Formula

C20H22O7

CAS 号

34444-37-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Heejeong Lee, et al. (-)-Nortrachelogenin from Partrinia scabiosaefolia elicits an apoptotic response in Candida albicans. FEMS Yeast Res. 2016 May;16(3):fow013.

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Nortrachelogenin(Synonyms: (-)-Wikstromol; (-)-Nortrachelogenin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Nortrachelogenin (Synonyms: (-)-Wikstromol; (-)-Nortrachelogenin)

Nortrachelogenin ((-)-Wikstromol) 可从 Partrinia scabiosaefolia 分离得到,可诱导 Candida albicans 的凋亡.

Nortrachelogenin(Synonyms: (-)-Wikstromol;  (-)-Nortrachelogenin)

Nortrachelogenin Chemical Structure

CAS No. : 34444-37-6

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5 mg ¥12800 询问价格 & 货期

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生物活性

Nortrachelogenin ((-)-Wikstromol) from Partrinia scabiosaefolia elicits an apoptotic response in Candida albicans[1].

分子量

374.38

Formula

C20H22O7

CAS 号

34444-37-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Heejeong Lee, et al. (-)-Nortrachelogenin from Partrinia scabiosaefolia elicits an apoptotic response in Candida albicans. FEMS Yeast Res. 2016 May;16(3):fow013.

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Daurinoline(Synonyms: 蝙蝠葛诺林碱)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Daurinoline (Synonyms: 蝙蝠葛诺林碱)

Daurinoline 是一种可以从 Menispermum dauricum 根中分离得到的生物碱。Daurinoline 可能是一种潜在的抗肿瘤药物或化学增敏剂,可用于化疗耐药的非小型肺癌 (NSCLC) 研究。

Daurinoline(Synonyms: 蝙蝠葛诺林碱)

Daurinoline Chemical Structure

CAS No. : 2831-75-6

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生物活性

Daurinoline is an alkaloid that can be isolated from the roots of Menispermum dauricum. Daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC research[1].

体外研究
(In Vitro)

Daurinoline inhibits the proliferation, migration, invasion and EMT phenotype of chemo-resistant NSCLC cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

610.74

Formula

C37H42N2O6

CAS 号

2831-75-6

中文名称

蝙蝠葛诺林碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dan-Dan Li, et al. Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol. Environ Toxicol Pharmacol. 2019 Feb;66:109-115.

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Daurinoline(Synonyms: 蝙蝠葛诺林碱)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Daurinoline (Synonyms: 蝙蝠葛诺林碱)

Daurinoline 是一种可以从 Menispermum dauricum 根中分离得到的生物碱。Daurinoline 可能是一种潜在的抗肿瘤药物或化学增敏剂,可用于化疗耐药的非小型肺癌 (NSCLC) 研究。

Daurinoline(Synonyms: 蝙蝠葛诺林碱)

Daurinoline Chemical Structure

CAS No. : 2831-75-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Daurinoline is an alkaloid that can be isolated from the roots of Menispermum dauricum. Daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC research[1].

体外研究
(In Vitro)

Daurinoline inhibits the proliferation, migration, invasion and EMT phenotype of chemo-resistant NSCLC cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

610.74

Formula

C37H42N2O6

CAS 号

2831-75-6

中文名称

蝙蝠葛诺林碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dan-Dan Li, et al. Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol. Environ Toxicol Pharmacol. 2019 Feb;66:109-115.

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Daurinoline(Synonyms: 蝙蝠葛诺林碱)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Daurinoline (Synonyms: 蝙蝠葛诺林碱)

Daurinoline 是一种可以从 Menispermum dauricum 根中分离得到的生物碱。Daurinoline 可能是一种潜在的抗肿瘤药物或化学增敏剂,可用于化疗耐药的非小型肺癌 (NSCLC) 研究。

Daurinoline(Synonyms: 蝙蝠葛诺林碱)

Daurinoline Chemical Structure

CAS No. : 2831-75-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Daurinoline is an alkaloid that can be isolated from the roots of Menispermum dauricum. Daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC research[1].

体外研究
(In Vitro)

Daurinoline inhibits the proliferation, migration, invasion and EMT phenotype of chemo-resistant NSCLC cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

610.74

Formula

C37H42N2O6

CAS 号

2831-75-6

中文名称

蝙蝠葛诺林碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dan-Dan Li, et al. Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol. Environ Toxicol Pharmacol. 2019 Feb;66:109-115.

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Cinnamtannin B-1(Synonyms: 肉桂单宁B-1)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Cinnamtannin B-1 (Synonyms: 肉桂单宁B-1) 纯度: ≥95.0%

Cinnamtannin B-1 是一种原花青素,具有多种生物学功能,包括抗氧化作用。Cinnamtannin B-1 抑制 RANKL 诱导的破骨细胞生成,预防卵巢切除诱导的骨质疏松。Cinnamtannin B-1 抑制可用于骨质疏松症和结肠癌的研究。

Cinnamtannin B-1(Synonyms: 肉桂单宁B-1)

Cinnamtannin B-1 Chemical Structure

CAS No. : 88082-60-4

规格 价格 是否有货 数量
1 mg ¥1200 In-stock
5 mg ¥2600 In-stock
10 mg ¥4350 In-stock
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Cinnamtannin B-1 相关产品

相关化合物库:

  • Natural Product Library Plus
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生物活性

Cinnamtannin B-1 is a proanthocyanidin with multiple biological functions, including antioxidant effects. Cinnamtannin B-1 inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced osteoporosis in vivo[1]. Cinnamtannin B-1 can be used for the research osteoporosis and colon cancers[1][2].

分子量

864.76

Formula

C45H36O18

CAS 号

88082-60-4

中文名称

肉桂单宁B-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Meng Li, et al. Cinnamtannin B-1 Prevents Ovariectomy-Induced Osteoporosis via Attenuating Osteoclastogenesis and ROS Generation. Front Pharmacol. 2020 Jul 10;11:1023.

    [2]. Patrick P Carriere, et al. Cinnamtannin B-1 inhibits cell survival molecules and induces apoptosis in colon cancer.Int J Oncol. 2018 Oct;53(4):1442-1454.

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