TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma[1].
IC50 & Target[1]
CK1α
体外研究 (In Vitro)
TMX-4116 (compound 16; 1 μM; 4 h) shows a high degradation preference for CK1α in MOLT4 cells[1]. TMX-4116 (250 nM, 4 h) induces primary target degradation of CK1α, while no downregulation of PDE6D, IKZF1, and IKZF3 in MOLT4 cells[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis[1]
Cell Line:
MOLT4 cells
Concentration:
1 μM
Incubation Time:
4 hours
Result:
Showed a high degradation preference for CK1α.
Western Blot Analysis[1]
Cell Line:
MOLT4, Jurkat, and MM.1S cells
Concentration:
0 nM, 40 nM, 200 nM, 1 μM
Incubation Time:
4 hours
Result:
Showed a high degradation preference for CK1α with the DC50 value less than 200 nM in MOLT4, Jurkat, and MM.1S cells.
分子量
389.43
Formula
C17H19N5O4S
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.
TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer[1].
IC50 & Target[1]
PDE6D
CK1α
体外研究 (In Vitro)
TMX-4113 (compound 21; 1 μM; 4 h) shows a high degradation preference for PDE6D and CK1α in MOLT4 cells[1]. TMX-4113 (0 nM, 40 nM, 200 nM, 1µM; 4h) induces degradation of PDE6D in MOLT4 cells[1]. TMX-4113 (0 nM, 40 nM, 200 nM, 1µM; 4h) degrades over 50% of CK1α at a dose of 40 nM in MM.1S cells[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis[1]
Cell Line:
MOLT4 cells
Concentration:
1 μM
Incubation Time:
4 h
Result:
Showed a high degradation preference for PDE6D and CK1α.
Western Blot Analysis[1]
Cell Line:
MOLT4 cells
Concentration:
0 nM, 40 nM, 200 nM, 1µM
Incubation Time:
4 h
Result:
Induced degradation of PDE6D.
分子量
308.38
Formula
C12H12N4O2S2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.
TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma[1].
IC50 & Target[1]
PDE6D
体外研究 (In Vitro)
TMX-4100 (compound 3; 1 μM; 4 h) shows a high degradation preference for PDE6D in MOLT4 cells[1]. TMX-4100 has better proteome-wide degradation selectivity in MOLT4 cells, compare to PDE6D degrader FPFT-2216[1]. TMX-4100 does not impede the growth of KRAS-dependent cell lines (MIA PaCa-2, NCI-H358, AGS, PA-TU-8988T cells)[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis[1]
Cell Line:
MOLT4 cells
Concentration:
1 μM
Incubation Time:
4 hours
Result:
Showed a high degradation preference for PDE6D.
Western Blot Analysis[1]
Cell Line:
MOLT4, Jurkat, and MM.1S cells
Concentration:
0 nM, 40 nM, 200 nM, 1 μM;
Incubation Time:
4 hours
Result:
Showed a high degradation preference for PDE6D with the DC50 value less than 200 nM.
分子量
262.29
Formula
C11H10N4O2S
CAS 号
2367619-63-2
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
DMSO : 100 mg/mL (381.26 mM; ultrasonic and warming and heat to 60°C)
