上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Tyrphostin AG1296 (Synonyms: AG1296) 纯度: 99.25%
Tyrphostin AG1296 是一种有效的、选择性血小板衍生生长因子受体 (PDGFR) 抑制剂,IC50 值为 0.8 μM。Tyrphostin AG1296 抑制人 PDGF α 和 β 受体以及相关干细胞因子受体 (c-Kit) 的信号传导。Tyrphostin AG1296 也是有效的 FLT3 抑制剂,IC50 值在微摩尔范围内。
Tyrphostin AG1296 Chemical Structure
CAS No. : 146535-11-7
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
10 mM * 1 mL in DMSO | ¥1100 | In-stock | |
5 mg | ¥1000 | In-stock | |
10 mg | ¥1700 | In-stock | |
25 mg | ¥3500 | In-stock | |
50 mg | ¥5500 | In-stock | |
100 mg | ¥9500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
Tyrphostin AG1296 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Immunology/Inflammation Compound Library
- Kinase Inhibitor Library
- Protein Tyrosine Kinase Compound Library
- Anti-Cancer Compound Library
- Reprogramming Compound Library
- Anti-Cardiovascular Disease Compound Library
- Anti-Blood Cancer Compound Library
- Angiogenesis Related Compound Library
- Anti-Liver Cancer Compound Library
生物活性 |
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range[1][2][3]. |
||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target |
|
||||||||||||||||||||||||
体外研究 (In Vitro) |
Tyrphostin AG1296 (0.625-20 μM; 72 h) suppresses viability of PLX4032-resistant melanoma cells[4]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[4]
Apoptosis Analysis[4]
Western Blot Analysis[4]
|
||||||||||||||||||||||||
体内研究 (In Vivo) |
Tyrphostin AG1296 (40 and 80 mg/kg; i.p. daily for two weeks) suppresses A375R tumor growth in vivo[4]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||||||||||||||||||
分子量 |
266.29 |
||||||||||||||||||||||||
Formula |
C16H14N2O2 |
||||||||||||||||||||||||
CAS 号 |
146535-11-7 |
||||||||||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||||||||||
储存方式 |
|
||||||||||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 33.33 mg/mL (125.16 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
|
||||||||||||||||||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务