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Quinacrine dihydrochloride (Synonyms: 阿的平; Mepacrine dihydrochloride; SN-390 dihydrochloride) 纯度: 99.01%
Quinacrine (Mepacrine) dihydrochloride 是一种有效的,具有口服活性的抗疟剂 (antimalarial),在体内外均具有抗肿瘤作用。Quinacrine dihydrochloride 抑制 NF-κB 并激活 p53 信号转导,诱导肿瘤细胞发生凋亡 (apoptosis)。
Quinacrine dihydrochloride Chemical Structure
CAS No. : 69-05-6
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥605 | In-stock | |
100 mg | ¥550 | In-stock | |
500 mg | ¥980 | In-stock | |
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5 g | 询价 |
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Quinacrine dihydrochloride 相关产品
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生物活性 |
Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis[1]. |
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体外研究 (In Vitro) |
Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
Apoptosis Analysis[1]
Western Blot Analysis[1]
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体内研究 (In Vivo) |
Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
472.88 |
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Formula |
C23H32Cl3N3O |
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CAS 号 |
69-05-6 |
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中文名称 |
奎纳克林二盐酸盐;阿的平;米帕林 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : ≥ 44 mg/mL (93.05 mM) H2O : 13.89 mg/mL (29.37 mM; Need ultrasonic) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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