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卢湘仪 大容量冷冻离心机 DL-8M

卢湘仪 大容量冷冻离心机 DL-8M

卢湘仪 大容量冷冻离心机 DL-8M

  • 商品品牌: 卢湘仪
    商品编号:DL-8M
  • 商品价格: 请与我们联系
  • 卢湘仪 大容量冷冻离心机 DL-8M-卢湘仪-DL-8M

    • 类型:大容量离心机
    • 主机最高转速:4001-10000rpm
    • 品牌属性:国产
    实验室常用设备|||混合分离|||离心机|||卢湘仪大容量冷冻离心机DL-8M
    大容量 冷冻 离心机 大容量离心机
    卢湘仪 大容量冷冻离心机 DL-8M产品简介:

    1、微机控制,数字显示;

    2、中英文操作系统,设定参数和运行参数同时显示,转速,离心力,

    温度时间等可自由设定;

    3、采用高性能进口压缩机组、无氟制冷剂R404a,符合环保要求;

    4、采用大力矩无刷变频电机驱动,免维护;

    5、主机和转子运动所有参数的自动存储;

    6、实时RPM/RCF之读数换算和设定,方便快捷;

    7、具有10个程序的升、降速离心曲线;

    8、设有不平衡、门盖自锁、超速、超温等多种程序的保护功能,

    配有电子门锁,确保仪器安全运行。


    商品属性

    • 类型:大容量离心机
    • 主机最高转速:4001-10000rpm
    • 品牌属性:国产
    商品属性
    商品名称 卢湘仪 大容量冷冻离心机 DL-8M-DL-8M-卢湘仪
    型号 DL-8M
    类别 实验室常用设备|||混合分离|||离心机|||卢湘仪大容量冷冻离心机DL-8M
    品牌 卢湘仪
    品牌简介 卢湘仪
    关键字 大容量 冷冻 离心机 大容量离心机,转速,离心机,温度,参数,程序,制冷剂

    卢湘仪 大容量冷冻离心机 DL-8M

    Dromostanolone propionate(Synonyms: Drostanolone propionate)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Dromostanolone propionate (Synonyms: Drostanolone propionate) 纯度: ≥97.0%

    Dromostanolone propionate (Drostanolone propionate) 是一种具有抗乳腺癌活性的化合物。Dromostanolone propionate 能抑制肿瘤对雌二醇 -17ß 的摄取,但对正常乳腺组织的摄取没有明显影响。Dromostanolone propionate 植入颗粒能使动物的体重增加并抑制雌性动物发情。

    Dromostanolone propionate(Synonyms: Drostanolone propionate)

    Dromostanolone propionate Chemical Structure

    CAS No. : 521-12-0

    规格 价格 是否有货 数量
    50 mg ¥500 In-stock
    100 mg ¥850 In-stock
    200 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Dromostanolone propionate (Drostanolone propionate) is a compound has antitumor activity against breast carcinoma[1]. Dromostanolone propionate inhibits the uptake of oestradiol-17ß by the tumour but has no apparent effect on the uptake by normal breast tissue [2]. Dromostanolone propionate implant pellet produces weight gains in animals and suppresses estrus in female animals[3].

    分子量

    360.53

    Formula

    C23H36O3

    CAS 号

    521-12-0

    中文名称

    屈他雄酮丙酸酯

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    参考文献
    • [1]. Takeuchi S, et al. Clinical experience with dromostanolone propionate (NSC-12198) in breast carcinoma. Saishin Igaku. 1967 May;22(5):1049-54.

      [2]. N.Deshpande, et al. Accumulation of tritiated oestradiol by human breast tissue. Steroids, 1967 Sep;10(3), 219–232.

      [3]. Brian H. Vickery . Dromostanolone propionate implant pellet useful for producing weight gains in animals and suppressing estrus in female animals. US3991750A.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Ribociclib succinate hydrate(Synonyms: LEE011 succinate hydrate)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Ribociclib succinate hydrate (Synonyms: LEE011 succinate hydrate) 纯度: 99.96%

    Ribociclib succinate hydrate (LEE011 succinate hydrate) 是一种高度特异性的 CDK4/6 抑制剂,IC50 值分别为 10 nM 和 39 nM,对 cyclin B/CDK1 复合体的活性低于其 1000 倍。

    Ribociclib succinate hydrate(Synonyms: LEE011 succinate hydrate)

    Ribociclib succinate hydrate Chemical Structure

    CAS No. : 1374639-79-8

    规格 价格 是否有货 数量
    10 mM * 1 mL in DMSO ¥1243 In-stock
    2 mg ¥560 In-stock
    5 mg ¥990 In-stock
    10 mg ¥1200 In-stock
    50 mg ¥4500 In-stock
    100 mg ¥6500 In-stock
    200 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    Ribociclib succinate hydrate 相关产品

    相关化合物库:

    • Drug Repurposing Compound Library Plus
    • FDA-Approved Drug Library Plus
    • FDA-Approved Drug Library Mini
    • Bioactive Compound Library Plus
    • Cell Cycle/DNA Damage Compound Library
    • Kinase Inhibitor Library
    • FDA-Approved Drug Library
    • Anti-Cancer Compound Library
    • CNS-Penetrant Compound Library
    • Anti-Aging Compound Library
    • Drug Repurposing Compound Library
    • Orally Active Compound Library
    • FDA Approved & Pharmacopeial Drug Library
    • Anti-Breast Cancer Compound Library
    • Anti-Pancreatic Cancer Compound Library
    • Anti-Blood Cancer Compound Library

    生物活性

    Ribociclib succinate hydrate (LEE011 succinate hydrate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

    IC50 & Target[1]

    CDK4

    10 nM (IC50)

    CDK6

    39 nM (IC50)

    体外研究
    (In Vitro)

    Treating a panel of 17 neuroblastoma cell lines with Ribociclib (LEE011) across a four-log dose range (10 to 10,000 nM). Treatment with Ribociclib significantly inhibits substrate adherent growth relative to the control in 12 of the 17 neuroblastoma cell lines examined (mean IC50=306±68 nM, considering sensitive lines only, where sensitivity is defined as an IC50 of less than 1 μM. Ribociclib treatment of two neuroblastoma cell lines (BE2C and IMR5) with demonstrated sensitivity to CDK4/6 inhibition results in a dose-dependent accumulation of cells in the G0/G1 phase of the cell cycle. This G0/G1 arrest becomes significant at Ribociclib concentrations of 100 nM (p=0.007) and 250 nM (p=0.01), respectively[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    CB17 immunodeficient mice bearing BE2C, NB-1643 (MYCN amplified, sensitive in vitro), or EBC1 (non-amplified, resistant in vitro) xenografts are treated once daily for 21 days with Ribociclib (LEE011; 200 mg/kg) or with a vehicle control. This dosing strategy is well tolerated, as no weight loss or other signs of toxicity are observed in any of the xenograft models. Tumor growth is significantly delayed throughout the 21 days of treatment in mice harboring the BE2C or 1643 xenografts (both, p<0.0001), although growth resumed post-treatment[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial

    分子量

    570.64

    Formula

    C27H38N8O6

    CAS 号

    1374639-79-8

    中文名称

    瑞博西尼琥珀酸盐水合物;瑞柏司可里布琥珀酸盐水合物

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    In Vitro: 

    DMSO : 100 mg/mL (175.24 mM; Need ultrasonic)

    H2O : 4 mg/mL (7.01 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.7524 mL 8.7621 mL 17.5242 mL
    5 mM 0.3505 mL 1.7524 mL 3.5048 mL
    10 mM 0.1752 mL 0.8762 mL 1.7524 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.38 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (4.38 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.38 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (4.38 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
    • 3.

      请依序添加每种溶剂: 10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.38 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (4.38 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献
    • [1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.

      [2]. Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.

    Cell Assay
    [2]

    Cells are grown for 24 hours in 35 mm plates, treated with 500 nM Ribociclib for 6 days, and then fixed and stained overnight. Cells are then imaged for SA-β-gal using an Axio Observer D.1 phase contrast microscope. The percentage of SA-β-gal positive cells is determined by counting the number of positive cells present in three separate microscope frames, and then normalizing to the control. To assess apoptotic activity, cells are plated in triplicate in 96 well plates, treated with Ribociclib, and assayed for caspase 3/7 activation 16 hours after treatment with Caspase-Glo 3/7. Cells treated with SN-38 are used as a positive control[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration
    [2]

    Mice[2]
    The BE2C, NB-1643, or EBC1 cell line-derived xenografts are implanted subcutaneously into the right flank of CB17 SCID-/- mice. Animals bearing engrafted tumors of 200-600 mm3 are then randomized to oral treatment with 200 mg/kg Ribociclib in 0.5 % methylcellulose (n=10) or vehicle (n=10) daily for a total of 21 days. Tumor burden is determined periodically throughout treatment according to the formula (π/6)×d2, where d represents the mean tumor diameter obtained by caliper measurement.

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    参考文献
    • [1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.

      [2]. Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Folic Acid-d2(Synonyms: 叶酸 d2)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Folic Acid-d2 (Synonyms: 叶酸 d2)

    Folic Acid-d2 是 Folic acid 的氘代物。Folic acid (Vitamin M; Vitamin B9)是维生素B9。

    Folic Acid-d2(Synonyms: 叶酸 d2)

    Folic Acid-d2 Chemical Structure

    CAS No. : 69022-87-3

    规格 价格 是否有货
    1 mg ¥2000 询问价格 & 货期
    5 mg ¥8000 询问价格 & 货期

    * Please select Quantity before adding items.

    生物活性

    Folic Acid-d2 is the deuterium labeled Folic acid. Folic acid (Vitamin M; Vitamin B9) is a B vitamin; is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.

    体外研究
    (In Vitro)

    Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    443.41

    Formula

    C19H17D2N7O6

    CAS 号

    69022-87-3

    中文名称

    叶酸 d2

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    多肽定制Dynorphin A (13-17) 编码

    上海金畔生物科技有限公司可以定制不同序列多肽,可以访问官网了解更多产品信息。

    名称 Dynorphin A (13-17)
    编码
    别名 Dynorphin A (13-17)
    纯度 80%,90%,95%,98%,99%
    重量 1mg,5mg,10mg,50mg,100mg,1g
    序列(单字母缩写) KWDNQ
    序列(三字母缩写) Lys-Trp-Asp-Asn-Gln
    基本描述
    溶解度
    分子量 689.73
    化学式 C30H43N9O10
    存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
    注释
    Documents Dynorphin A (13-17)          编码
    Figures Dynorphin A (13-17)          编码
    Reference
    C端
    N端
    化学桥

    天名精内酯酮对照品

    天名精内酯酮对照品

      【编号】:PR0314

      【产品名称】:天名精内酯酮对照品

      【规格】:10mg

      【用途】:

      天名精内酯酮对照品

      编号:PR0314
      英文名称:Carabrone
      英文别名:Grandicin
      Cas 号: 1748-81-8
      分 子 式:C15H20O3
      分 子 量:248.322
      植物来源:天名精
      来源: the fruits of Carpesium abrotanoides. Also from Inula grandis
      纯度: 95%~99%
      分析方法: HPLC-DAD or/and HPLC-ELSD
      鉴定方法: 质谱(Mass), 核磁(NMR)
      包装: 棕色小玻璃瓶,标准包装10mg,20mg,50mg;可以按客户需求包装。
      类别:上海金畔生物科技有限公司,天然提取物
      作为标准品,对照品或者供研究用,不能直接用于人体。

    抗生素检定培养基4号

    上海金畔生物科技有限公司可以定制生产国产培养基,可以访问官网了解更多产品信息。
    抗生素检定培养基4号

    英文名称: Antibiotic Agar No.4
    产品货号: JP5207
    产品规格: 250g
    100元
    保质期: 三年
    产品用途: 用于两性霉素B等的效价测定
    备  注:

    产品介绍:

    用途:用于两性霉素 B等的效价测定。

    成分(g/L):

    蛋白胨 10.0
    氯化钠 10.0
    葡萄糖 10.0
    琼脂 20.0
    枸橼酸钠 10.0
    pH值6.1±0.1 25℃

    检验原理
    本法是利用抗生素在琼脂培养基内的扩散作用,抑菌圈直径与抗生素的浓度或活性有关;比较标准品与供试品两者对接种的试验菌产生抑菌圈的大小,以测定供试品效价的一种微生物学方法。

    用法

    称取本品 60.0g,加热溶解于 1000ml 纯化水中,分装,115℃高压灭菌 30 分钟,备用。

    抗生素检定培养基微生物质控结果:

    抗生素检定培养基4号(ph6.0-6.2)微生物灵敏度试验:

    按标签用法制备培养基,接种以下质控菌株,放置36±1℃需氧培养24-36小时。
    注:回收率计算时,用SDA琼脂做对照培养基。


    抗生素检定培养基4号相关产品:

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    Antibiotic Agar NO.1
    250g 用于链霉素、卡那霉素、庆大霉素、红霉素等效价检定
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    250g 用于磺苄青霉素效价检定
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    250g 用于林可霉素,克林霉素等效价测定
    JP5196-1 抗生素检定培养基2号(低pH)
    Antibiotic Agar NO.2
    250g 用于四环素,土霉素等效价测定
    JP8692 抗生素检定培养基3号
    Antibiotic Agar NO.3
    250g 用于藤黄八叠球菌菌悬液制备
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    Antibiotic Agar NO.4
    250g 用于两性霉素B等的效价测定
    JP5209 抗生素检定培养基7号
    Antibiotic Agar NO.7
    250g 用于头孢噻肟钠等的效价测定
    JP5210 抗生素检定培养基8号
    Antibiotic Agar NO.8
    250g 用于去甲万古霉素等的效价测定
    JP5212 抗生素检定培养基5号(pH7.8-8.0)
    Antibiotic NO.5
    250g 用于两性霉素B检定菌种培养
    JP5208 抗生素检定培养基6号
    Antibiotic Agar NO.6
    250g 用于粘菌素等的效价测定
    JP5235 麦迪、麦白霉素检定培养基(普通轻质斜面培养基)
    Wheat albomycin Test Medium
    250g 麦迪(白)霉素效价测定
    JP5234 阿奇霉素检定培养基
    Azithromycin Test Medium
    250g 阿奇霉素效价测定
    JP5233 制霉素检定培养基
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    250g 制霉素效价测定
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    JP5231 抗生素检定培养基9号
    Antibiotic Agar NO.9
    250g 白色念珠菌悬液抗生素效价测定
    JP5196-2 抗生素检定培养基2号高PH8.0-8.2
    Antibiotic Agar NO.2 (PH8.0-8.2)
    250g 用于林可霉素,克林霉素等效价测定
    JP5212-1 抗生素检定培养基5号(pH6.0-6.2)
    Antibiotic No.5(pH6.0-6.2)
    250g 用于两性霉素B检定培养
    JP5196-3 抗生素检测培养基II
    Antibiotic Agar No.2
    250g 用于拮抗剂检测
    JP5195-2 抗生素检定培养基1号(PH6.5-6.7)
    Medium 1
    250g 用于药品抗生素效价测定
    JP5195-1 抗生素检定培养基1号(低PH)
    Antibiotic Agar No.1
    250g 用于磺苄青霉素效价测定
    JP5195 抗生素检定培养基1号(低PH)
    Antibiotic Agar No.1
    250g 用于磺苄青霉素效价测定
    JP5207-1 抗生素检定培养基4号(PH6.5-6.6)
    Antibiotic Agar No.4
    250g 用于盐霉素钠、莫能菌素及其制剂等效价测定
    JP5207-3 抗生素检定培养基4号
    Antibiotic Agar No.4
    250g 用于盐霉素钠、莫能菌素及其制剂等效价测定
    JP5208-1 抗生素检定培养基6号(7.8-8.0)
    Antibiotic Agar No.6
    250g 用于粘菌素等的效价测定
    JP8838 0.5%葡萄糖肉汤琼脂
    0.5% Dextrose Agar
    250g 用于硫酸链霉素等抗生素的无菌检查
    JPPC001 JP四连式牛津杯
    JP Four-Part Attached Oxford Cup
    10个*15包/箱 应用于药敏试验
    JP8843 培养基C(EP标准)
    Medium C
    250g 用于抗生素效价测定
    JP8842 培养基B(EP标准)
    Medium B
    250g 用于抗生素效价测定
    JP8844 培养基1(USP)(Medium 1)
    Medium 1
    250g 用于微生物方法测定抗生素效价
    JP8845 培养基2(USP)(Medium 2)
    Medium 2
    250g 用于微生物方法测定抗生素效价
    JP8856 抗生素检定培养基8号(USP)(Medium 8)
    Medium 8
    250g 用于万古霉素效价测定的菌层培养基
    JP8857 培养基32(USP)(Medium 32)
    Medium 32
    250g 用于双氢链霉素、万古霉素等效价测定

    Procaine hydrochloride(Synonyms: 盐酸普鲁卡因)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Procaine hydrochloride (Synonyms: 盐酸普鲁卡因) 纯度: 99.94%

    Procaine hydrochloride 是 DNA 脱甲基剂。Procaine hydrochloride 通过多个靶标起作用,起效缓慢,作用持续时间短。

    Procaine hydrochloride(Synonyms: 盐酸普鲁卡因)

    Procaine hydrochloride Chemical Structure

    CAS No. : 51-05-8

    规格 价格 是否有货 数量
    Free Sample (0.1-0.5 mg)   Apply now  
    500 mg ¥400 In-stock
    1 g ¥500 In-stock
    5 g ¥800 In-stock
    10 g   询价  
    50 g   询价  

    * Please select Quantity before adding items.

    Procaine hydrochloride 相关产品

    相关化合物库:

    • Drug Repurposing Compound Library Plus
    • FDA-Approved Drug Library Plus
    • Bioactive Compound Library Plus

    生物活性

    Procaine hydrochloride is a DNA-demethylating agent. Procaine hydrochloride acts through multiple targets and has a slow onset and a short duration of action[1][2].

    体外研究
    (In Vitro)

    Procaine hydrochloride (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM[1]. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest[2]. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale[3].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial

    分子量

    272.77

    Formula

    C13H21ClN2O2

    CAS 号

    51-05-8

    中文名称

    盐酸普鲁卡因;盐酸普罗卡因;盐酸奴佛卡因;盐酸奴呋卡因;盐酸奴夫卡因

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, sealed storage, away from moisture and light

    *该产品在溶液状态不稳定,建议您现用现配,即刻使用。

    溶解性数据
    In Vitro: 

    DMSO : 50 mg/mL (183.30 mM; Need ultrasonic)

    H2O : ≥ 50 mg/mL (183.30 mM)

    * “≥” means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.6661 mL 18.3305 mL 36.6609 mL
    5 mM 0.7332 mL 3.6661 mL 7.3322 mL
    10 mM 0.3666 mL 1.8330 mL 3.6661 mL

    *

    请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: PBS

      Solubility: 130 mg/mL (476.59 mM); Clear solution; Need ultrasonic

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献
    • [1]. Fan, P. and F.F. Weight, Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons. Neuropharmacology, 1994. 33(12): p. 1573-9.

      [2]. Villar-Garea, A., et al., Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res, 2003. 63(16): p. 4984-9.

      [3]. Adamec, R.E. and C. Stark-Adamec, The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits. Prog Neuropsychopharmacol Biol Psychiatry, 1987. 11(4): p. 345-64.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Nolatrexed-d4 dihydrochloride(Synonyms: 盐酸诺拉曲塞 d4 (双盐酸盐))

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Nolatrexed-d4 dihydrochloride (Synonyms: 盐酸诺拉曲塞 d4 (双盐酸盐))

    Nolatrexed-d4 dihydrochloride 是 Nolatrexed dihydrochloride 的氘代物。Nolatrexed dihydrochloride (AG 337) 是一种非竞争性的胸苷酸合酶 (thymidylate synthase) 抑制剂,与该酶的叶酸辅因子结合位点相互作用,对人 thymidylate synthase 的 Ki 值为 11 nM。Nolatrexed dihydrochloride (AG 337) 能够在癌细胞 S 期诱导细胞周期停滞。具有抗癌活性。

    Nolatrexed-d4 dihydrochloride(Synonyms: 盐酸诺拉曲塞 d4 (双盐酸盐))

    Nolatrexed-d4 dihydrochloride Chemical Structure

    规格 是否有货
    1 mg Check price and availability
    10 mg Check price and availability

    * Please select Quantity before adding items.

    生物活性

    Nolatrexed-d4 dihydrochloride (AG 337-d4) is the deuterium labeled Nolatrexed dihydrochloride. Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity[2].

    体外研究
    (In Vitro)

    Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    361.28

    Formula

    C14H10D4Cl2N4OS

    中文名称

    盐酸诺拉曲塞 d4 (双盐酸盐)

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

      [2]. Webber S, et al. AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer Chemother Pharmacol. 1996;37(6):509-17.

      [3]. McGuire JJ, et al. Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Brand普兰德 PCR8联管 管盖(781334)

    Brand普兰德 PCR8联管 管盖(781334)

    Brand普兰德 PCR8联管 管盖(781334)

  • 商品品牌: Brand普兰德
    商品编号:781334
  • 商品价格: 请与我们联系
  • Brand普兰德 PCR8联管 管盖(781334)-Brand普兰德-781334

    • 产品类型:其他
    • 品牌属性:进口
    实验室耗材|||分子生物|||PCR管|||Brand普兰德PCR8联管管盖(781334)
    PCR管

    Brand普兰德 PCR8联管 管盖(781334)

    产品描述

    PP材质。八联管,圆形盖。单独的突盖或平盖都有8联形式。容易开盖或关盖,无需借助其他工具。管子一端带有手持条带,同时联盖的每个盖子边缘的都有小的唇形设计,便于开闭盖与防治污染。

    产品资料下载: BRAND PCR产品介绍.pdf


    商品属性

    • 产品类型:其他
    • 品牌属性:进口
    商品属性
    商品名称 Brand普兰德 PCR8联管 管盖(781334)-781334-Brand普兰德
    型号 781334
    类别 实验室耗材|||分子生物|||PCR管|||Brand普兰德PCR8联管管盖(781334)
    品牌 Brand普兰德
    品牌简介 Brand普兰德
    关键字 PCR管,普兰,圆形,无色,条带,盖子,产品描述

    Brand普兰德 PCR8联管 管盖(781334)

    德国WIGGENS 60024台式多功能振荡混匀器

    【简单介绍】

    德国WIGGENS 60024台式多功能振荡混匀器可以在桌面上放置的台式振荡和混匀装置。可以长时间连续工作,调速马达提供低速到高速强力的振荡。不需要负载平衡,带有一个易拆装的振荡头,能够使用各种不同形式的玻璃器皿。可以放在通风柜中进一步增加安全性。

    【详细说明】

    德国WIGGENS 60024台式多功能振荡混匀器

     

    产品简述:   

        德国WIGGENS 60024台式多功能振荡混匀器,可以在桌面上放置的台式振荡和混匀装置。可以长时间连续工作,调速马达提供低速到高速强力的振荡。不需要负载平衡,带有一个易拆装的振荡头,能够使用各种不同形式的玻璃器皿。可以放在通风柜中进一步增加安全性。

     

    技术特点:

    1. 可以使用多种支架适用于更广泛的应用
    2. 速度可调以达到更好的振荡效果
    3. 直流滤波马达,负载大,长时间可靠稳定运行
    4. 模拟手动的运动方式
    5. 节省成本,而且具有更高的安全性
    6. 大承重9.1kg. 大电流1.0A, 外形尺寸:330x254x298mm

     

    订货信息:

    定货号

    描述

    转速(RPM)

    重量kg)

    60024

    振荡器主机

    2-125

    25

     

    台式多功能振荡器  
    60024 台式多功能振荡器
    分液漏斗承载支架 (大500 ml)  
    FR435SS 分液漏斗承载支架
    FR600SS 分液漏斗承载支架
    分液漏斗承载支架 (1000 ml &更大)  
    BT1000S 分液漏斗承载支架
    BT2000S 分液漏斗承载支架
    R80 258 分液漏斗承载支架
    R80 2552 分液漏斗承载支架
    锥形瓶承载支架  
    EF521 锥形瓶承载支架
    脂肪提取管支架  
    MFG3 脂肪提取管支架
    试管架振荡头  
    TR700 试管架振荡头
    通用安装平台  
    BT6000 通用安装平台
    大三爪夹  
    344 大三爪夹
    离心管支架  
    SR815 离心管支架
    SR850 离心管支架

    Docetaxel-d9(Synonyms: RP-56976-d9)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Docetaxel-d9 (Synonyms: RP-56976-d9) 纯度: ≥98.0%

    Docetaxel-d9 (RP-56976-d9) 是 Docetaxel 的氘代物。Docetaxel (RP-56976) 是一种微管解聚 (microtubule depolymerization) 抑制剂,其 IC50 值为 0.2 μM。Docetaxel 是紫杉醇的半合成类似物,能减弱 bcl-2 和 bcl-xL 基因表达的影响。Docetaxel 阻滞 G2/M 细胞周期,导致细胞凋亡 (apoptosis)。Docetaxel 具有抗肿瘤活性。

    Docetaxel-d9(Synonyms: RP-56976-d9)

    Docetaxel-d9 Chemical Structure

    CAS No. : 940867-25-4

    规格 价格 是否有货 数量
    1 mg ¥6600 In-stock
    10 mg ¥30500 In-stock
    50 mg   询价  
    100 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Docetaxel-d9 (RP-56976-d9) is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity[1][3].

    体外研究
    (In Vitro)

    Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    816.93

    Formula

    C43H44D9NO14

    CAS 号

    940867-25-4

    中文名称

    多西他赛 d9

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    参考文献
    • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

      [2]. Attia RT, et al. The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells. PeerJ. 2016 Jun 29;4:e2168.;Che CL, et al. DNA microarray reveals different pathways responding to NSC 125973 and docetaxel in non-small cell lung cancer cell line. Int J Clin Exp Pathol. 2013 Jul 15;6(8):1538-48.;Obi-Ioka Y, et al. Involvement of Wee1 in the circadian rhythm dependent intestinal damage induced by docetaxel. J Pharmacol Exp Ther. 2013 Oct;347(1):242-8.;Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    实验耗材细胞培养板CCP06-006


    实验耗材细胞培养板

    • 产品型号:CCP06-006
    • 简要描述:实验耗材细胞培养板金畔生物公司供应:ELISA试剂盒,分光光度计,血清,荧光定量PCR耗材,移液器吸嘴,微量离心管,进口冻存管,细胞培养皿,培养板,培养瓶,吸头,仪器及手套,色谱耗材,针头过滤器。
    产品咨询在线客服
    • 产品简介

    实验耗材细胞培养板金畔生物公司供应:elisa试剂盒,动物血清,荧光定量PCR耗材,移液器吸嘴,微量离心管,进口冻存管,细胞培养皿,培养板,培养瓶,进口吸头,仪器及手套,色谱耗材,针头过滤器,分光光度计。

    细胞培养板:

    每孔均有数字与字母标注,易于定位。板盖一端具有两个斜角导向设计,防止交叉污染。孔周围的低挥发槽,可有效降低孔内液体蒸发。增高的孔边缘,极大的降低了交叉污染的风险。每块培养板均为独立包装。

    细胞培养耗材表面处理采用先进的等离子处理技术。相比传统的电晕/TC处理贴壁效果更佳表面更均匀。

    采用无细胞毒素的聚苯乙烯材质制成

    好的透光性,方便观察细胞各阶段形态

    无菌、无RNase/DNase、无热原

    实验耗材细胞培养板

    订货号

    描述

    包装

    CCP06-006

    细胞培养板;6孔

    1个/包;100个/箱

    CCP06-012

    细胞培养板;12孔

    1个/包;100个/箱

    CCP06-024

    细胞培养板;24孔

    1个/包;100个/箱

    CCP06-048

    细胞培养板;48孔

    1个/包;100个/箱

    CCP06-096

    细胞培养板;96孔

    1个/包;100个/箱

    实验耗材细 胞培养板

    细胞培养皿

    实验耗材 圆底高速离心管

    实验耗材 圆底离心管

    适应客户:医院检验科PCR实验室,中心实验室,肝病中心;第三方检测机构,科研院所,大专院校,制药厂,试剂生产厂家,疾控中心,检验检疫。

    Anagrelide hydrochloride(Synonyms: 盐酸阿那格雷; BL4162A)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Anagrelide hydrochloride (Synonyms: 盐酸阿那格雷; BL4162A) 纯度: 99.65%

    Anagrelide盐酸盐 (BL4162A) 对血小板增多症有效。

    Anagrelide hydrochloride(Synonyms: 盐酸阿那格雷; BL4162A)

    Anagrelide hydrochloride Chemical Structure

    CAS No. : 58579-51-4

    规格 价格 是否有货 数量
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    生物活性

    Anagrelide hydrochloride (BL4162A) is a drug used for the treatment of essential thrombocytosis. Target: PDE Anagrelide hydrochloride is an oral imidazoquinazoline agent that has been shown to reduce elevated platelet counts and the risk of thrombosis in patients with thrombocythaemia in various myeloproliferative disorders (MPD). It is currently approved by the FDA as oral treatment for essential thrombocythaemia (ET) and thrombocythaemia associated with polycythaemia vera (PV). Anagrelide is known to inhibit platelet cyclic adenosine monophosphate (cAMP) phosphodiesterase at concentrations that exceed those achieved at doses used to treat ET. Anagrelide is extensively metabolised in the liver and its metabolites are primarily excreted in the urine [1]. Anagrelide is an established platelet-reducing drug. Studies have also investigated the effects of anagrelide on platelets, indicating that platelet function is as important as platelet counts in ET [2].

    Clinical Trial

    分子量

    292.55

    Formula

    C10H8Cl3N3O

    CAS 号

    58579-51-4

    中文名称

    盐酸阿那格雷

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    In Vitro: 

    DMSO : 7.69 mg/mL (26.29 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.4182 mL 17.0911 mL 34.1822 mL
    5 mM 0.6836 mL 3.4182 mL 6.8364 mL
    10 mM 0.3418 mL 1.7091 mL 3.4182 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 0.77 mg/mL (2.63 mM); Suspended solution; Need ultrasonic

      此方案可获得 0.77 mg/mL (2.63 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

      以 1 mL 工作液为例,取 100 μL 7.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 0.77 mg/mL (2.63 mM); Suspended solution; Need ultrasonic

      此方案可获得 0.77 mg/mL (2.63 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

      以 1 mL 工作液为例,取 100 μL 7.7 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
    • 3.

      请依序添加每种溶剂: 10% DMSO    90% corn oil

      Solubility: ≥ 0.77 mg/mL (2.63 mM); Clear solution

      此方案可获得 ≥ 0.77 mg/mL (2.63 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例,取 100 μL 7.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献
    • [1]. Pescatore, S.L. and C. Lindley, Anagrelide: a novel agent for the treatment of myeloproliferative disorders. Expert Opin Pharmacother, 2000. 1(3): p. 537-46.

      [2]. Petrides, P.E., Anagrelide: what was new in 2004 and 2005? Semin Thromb Hemost, 2006. 32(4 Pt 2): p. 399-408.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    卢湘仪 高速冷冻离心机角转子 GL-12M-NO.3 2000ml

    卢湘仪 高速冷冻离心机角转子 GL-12M-NO.3  2000ml

    卢湘仪 高速冷冻离心机角转子 GL-12M-NO.3 2000ml

  • 商品品牌: 卢湘仪
    商品编号:GL-12M-NO.3
  • 商品价格: 请与我们联系
  • 卢湘仪 高速冷冻离心机角转子 GL-12M-NO.3 2000ml-卢湘仪-GL-12M-NO.3

    • 转子规格:大于1000ml
    • 转子转速:4001-10000rpm
    实验室常用设备|||混合分离|||离心机转子|||卢湘仪高速冷冻离心机角转子GL-12M-NO.32000ml
    角转子 水平转子 酶标转子 连续转子
    卢湘仪 高速冷冻离心机角转子 GL-12M-NO.3产品简介:

    1、最大容量:2000ml*4;

    2、最高转速:6000r/min;

    3、最大相对离心力:8410*g;


    商品属性

    • 转子规格:大于1000ml
    • 转子转速:4001-10000rpm
    商品属性
    商品名称 卢湘仪 高速冷冻离心机角转子 GL-12M-NO.3 2000ml-GL-12M-NO.3-卢湘仪
    型号 GL-12M-NO.3
    类别 实验室常用设备|||混合分离|||离心机转子|||卢湘仪高速冷冻离心机角转子GL-12M-NO.32000ml
    品牌 卢湘仪
    品牌简介 卢湘仪
    关键字 角转子 水平转子 酶标转子 连续转子,转子,可编程,液晶显示,操作,离心力,转速

    卢湘仪 高速冷冻离心机角转子 GL-12M-NO.3  2000ml

    RSP01-BGII分体式微量单推注射泵RSP01-BG2

    【简单介绍】

    品牌 其他品牌 产地 国产
    输送介质 类型 其他
    驱动方式 其他 泵轴位置 其他
    扬程 9m

    RSP01-BGII分体式微量单推注射泵RSP01-BG2是一款分体式、多通道可串联推拉型注射泵,多可完成大8通道注射泵的独立控制,RSP01-BGII能够装卡不同规格的注射器(进样器),多可以串联8个通道同时工作。广泛用于生物、化学反应注射实验、长时间动物药物注射实验、静电纺丝、微流控领域应用及其他实验室微量注射实验等,通过机械装置推动注射器,实现高精度,平稳的液体传输。
    现货常备。

    【详细说明】

    RSP01-BGII分体式微量单推注射泵RSP01-BG2

    产品特点:

      RSP01-BGII微量注射泵是一款分体式、多通道可串联推拉型注射泵,多可完成大8通道注射泵的独立控制,RSP01-BGII能够装卡不同规格的注射器(进样器),广泛用于生物、化学反应注射实验、长时间动物药物注射实验、静电纺丝、微流控领域应用及其他实验室微量注射实验等,通过机械装置推动注射器,实现高精度,平稳的液体传输。

    产品特点

    1、多道独立性:选用分体式、可串联多通道独立控制注射泵,1个控制器(触摸屏或电脑)完成多通道的任意组合任务;

    2、直观且易用:采用4.3英寸带有触摸功能的多彩液晶显示屏,显示直观,操作简单;

    3、电脑控制:可通过USB-TTL232通讯线连接设备至电脑,通过后台软件对其控制;

    4、洁净无隐忧:连接无线鼠标遥控工作,让注射泵在超净工作台等封闭环境中无隐忧操作;

    5DIY功能:提供底层动态库及编程接口,用户可在个人电脑通过C#C++VB等编程语言进行二次开发;

    6、精确校准:程序自带流量校准功能,消除工作产生的体积误差;

    7、保护设置:通过设置左右极限位置,保护注射器不被损坏;

    8、掉电记忆:系统自动保存当前运行参数,重新上电后可直接开始工作。

    9、多厂家模式:程序中集合了市场95%以上的常用注射器型号,并可自动记忆新输入的注射器.

    技术指标

    产品型号:RSP01-BGII

    通道数量:1~8(根据需要自选)

    每微步注射量:0.000313uL(100uL注射器)

    适用注射器类型:0.5uL-1mL

    每微步注射距离: 0.156um

    流量范围:0.1uL/h-2.02mL/min

    大线速度:79.4mm/min

    小线速度:7.9um/min

    大步速:6933 Step/s

    小步速:0.02533 Step/s

    工作模式:推拉

    线性推力:>30N

    控制精度:当>30%满行程时,控制误差<=0.1%

    控制及显示:4.3寸液晶多彩触摸屏

    电压范围:DC18V-DC36V

    工作环境:温度5-40℃,相对湿度<80%

    主机外形尺寸:175*45*66mm

    主机重量:0.6Kg

    触摸屏外形尺寸:118*86*34mm

    注射器选型参考

    注射器规格(注射器内径):小流量uL/min~大流量mL/min

    0.5uL0.103):0.000003954 uL/min~0.005999 mL/min

    1uL0.1457mm):0.000007912 uL/min~0.012004 mL/min

    2uL0.206mm):0.000015817 uL/min~0.023996 mL/min

    5uL0.343mm):0.000043852 uL/min~0.06652 mL/min

    10uL0.46mm): 0.000157 uL/min~0.119653 mL/min

    25uL0.73mm):0.000397 uL/min~0.301339mL/min

    50uL1.03mm):0.000791 uL/min~0.599907mL/min

    100uL1.46mm):0.001590 uL/min~1.205356mL/min

    250uL2.3mm):0.003946 uL/min~2.991336mL/min

    500uL3.26mm):0.007927uL/min~6.009589mL/min

    1000uL4.61mm):0.015852uL/min~12.01742mL/min

    注:不同厂家的注射器规格稍有不同。

    RSP01-BGII分体式微量单推注射泵RSP01-BG2

    Ramatroban(Synonyms: 雷马曲班; BAY u3405)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Ramatroban (Synonyms: 雷马曲班; BAY u3405) 纯度: 99.10%

    Ramatroban 是一种选择性血栓素 A2 (TxA2IC50=14 nM) 拮抗剂。Ramatroban 还通过抑制 PGD2 结合从而拮抗 CRTH2 (IC50=113 nM)。

    Ramatroban(Synonyms: 雷马曲班; BAY u3405)

    Ramatroban Chemical Structure

    CAS No. : 116649-85-5

    规格 价格 是否有货 数量
    Free Sample (0.1-0.5 mg)   Apply now  
    10 mM * 1 mL in DMSO ¥748 In-stock
    10 mg ¥680 In-stock
    50 mg ¥2100 In-stock
    100 mg ¥3200 In-stock
    200 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    Ramatroban 相关产品

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    • Drug Repurposing Compound Library Plus
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    • FDA-Approved Drug Library
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    • Drug Repurposing Compound Library
    • Endocrinology Compound Library
    • FDA Approved & Pharmacopeial Drug Library
    • Angiogenesis Related Compound Library
    • Rare Diseases Drug Library

    生物活性

    Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.

    IC50 & Target[1]

    hTP

    14 nM (IC50)

    hDP2

    311 nM (IC50)

    hDP1

    33.4 μM (IC50)

    CYP 2C9

    15 μM (IC50)

    体外研究
    (In Vitro)

    Ramatroban is a potent human thromboxane receptor (hTP) antagonist with an IC50 of 18 nM in a human TP binding assay. Ramatroban inhibits prostaglandin D2 receptor DP2 (CRTH2) with an IC50 of 113 nM in a human DP2 binding assay. Ramatroban also inhibits human CYP isoform CYP2C9 with an IC50 of 15 μM[1]. Ramatroban is a selective thromboxane-type prostanoid (TP) receptor antagonist. PGD2-stimulated human eosinophil migration is shown to be mediated exclusively through activation of CRTH2, and surprisingly, these effects are completely inhibited by Ramatroban. Ramatroban is an antagonist for CRTH2, and inhibits PGD2-induced migration of eosinophils via CRTH2 blockade. 3H-labeled PGD2 binds to a single site on CRTH2 transfectants with high affinity (KD=6.3 nM, Bmax=450 pM). Nonlabeled PGD2 inhibits the binding of 3H-labeled PGD2 to CRTH2 transfectants in a concentration-dependent manner with an EC50 value of 2.7 nM. Ramatroban shows significant inhibitory effects on the binding of 3H-labeled PGD2 to CRTH2, albeit with much lower potency (IC50=100 nM). Ramatroban also inhibits PGD2-induced Ca2+ mobilization in CRTH2 transfectants to almost the same extent with an IC50 value of 30 nM. Ramatroban completely inhibits the PGD2-induced migration of eosinophils in a concentration-dependent manner with an IC50 value of 170 nM[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    Ramatroban is an orally bioavailable small molecule antagonist of CRTH2. Systemic administration of Ramatroban (30 mg/kg) in CRTH2+/+ mice produces the same effects as seen in CRTH2 deficiency. Ramatroban completely blocks LPS-induced decreases in social and object exploratory behavior (p<0.01). In addition, tumor-impaired social interaction and object exploratory behavior in CRTH2+/+ mice are completely reversed by a single injection of Ramatroban, even when the tumor is enlarged[3].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial

    分子量

    416.47

    Formula

    C21H21FN2O4S

    CAS 号

    116649-85-5

    中文名称

    雷马曲班

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 125 mg/mL (300.14 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.4011 mL 12.0057 mL 24.0113 mL
    5 mM 0.4802 mL 2.4011 mL 4.8023 mL
    10 mM 0.2401 mL 1.2006 mL 2.4011 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (4.99 mM); Clear solution

      此方案可获得 ≥ 2.08 mg/mL (4.99 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (4.99 mM); Clear solution

      此方案可获得 ≥ 2.08 mg/mL (4.99 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
    • 3.

      请依序添加每种溶剂: 10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (4.99 mM); Clear solution

      此方案可获得 ≥ 2.08 mg/mL (4.99 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献
    • [1]. Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51.

      [2]. Sugimoto H, et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52.

      [3]. Haba R, et al. Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci. 2014 Feb 12;34(7):2514-23.

    Kinase Assay
    [2]

    CRTH2 transfectants are resuspended in binding buffer (50 mM Tris-HCl, pH 7.4, 40 mM MgCl2, 0.1% BSA, 0.1% NaN3). Cell suspension (2×105 cells), 3H-labeled PGD2, and various concentrations of Ramatroban (0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM and 10 μM) are then mixed in a 96-well U-bottomed polypropylene plate and incubated in a final volume of 100 μL for 60 min at room temperature. After incubation, the cell suspension is transferred to a filtration plate and washed three times with binding buffer. Scintillant is added to the filtration plate, and radioactivity remaining on the filter is measured by a scintillation counter. Nonspecific binding is determined by incubating the cell suspension and 3H-labeled PGD2 in the presence of 1 μM unlabeled PGD2[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Assay
    [2]

    Human eosinophils are purified and resuspended in migration buffer (20 mM HEPES, pH 7.6, 0.1% BSA, Hanks’ solution) at a density of 6 ×106 cells/mL. Fifty microliters of the cell suspension (3×105 cells/well) is then dispensed into the upper chamber of a 96-well type chemotaxis chamber (pore diameter=5 μm), and 30 μL of ligand solution is added to the lower chamber. Cells are preincubated with various concentrations of Ramatroban (0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM and 10 μM) or BWA868C at 37°C for 10 min. The migration assays are performed in a humidified incubator at 37°C, 5% CO2 for 2 h. The number of cells migrating into the lower chamber is counted[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration
    [3]

    Mice[3]
    Five micrograms of LPS (closed columns) or saline (open columns) are intraperitoneally injected into CRTH2+/+ mice. CRTH2+/+ mice are pretreated intraperitoneally for 1 h with 30 mg/kg Ramatroban.

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    参考文献
    • [1]. Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51.

      [2]. Sugimoto H, et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52.

      [3]. Haba R, et al. Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci. 2014 Feb 12;34(7):2514-23.

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    Urea-15N2(Synonyms: Carbamide-15N2; Carbonyldiamide-15N2)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Urea-15N2 (Synonyms: Carbamide-15N2; Carbonyldiamide-15N2)

    Urea-15N2 (Carbamide-15N2) 是 15N 标记的 Urea。Urea是一种强效蛋白质变性剂,作用通过直接和间接机制。 一种有效的润肤剂和角质层分离剂。 用作利尿剂。 血尿素氮 (BUN) 已被用于评估肾功能。 广泛用于肥料中的氮源,是化学工业的重要原料。

    Urea-15N2(Synonyms: Carbamide-15N2;  Carbonyldiamide-15N2)

    Urea-15N2 Chemical Structure

    CAS No. : 2067-80-3

    规格 价格 是否有货
    50 mg ¥1200 询问价格 & 货期
    100 mg ¥2000 询问价格 & 货期
    250 mg ¥4600 询问价格 & 货期

    * Please select Quantity before adding items.

    生物活性

    Urea-15N2 (Carbamide-15N2) is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

    体外研究
    (In Vitro)

    Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    62.04

    Formula

    CH415N2O

    CAS 号

    2067-80-3

    中文名称

    尿素 15N2

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

      [2]. Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7.

      [3]. Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 15;19(11):20392.

      [4]. Wang H, et al. Urea. Subcell Biochem. 2014;73:7-29.

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    Xylitol(Synonyms: 木糖醇; Xylite)

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Xylitol (Synonyms: 木糖醇; Xylite) 纯度: ≥98.0%

    Xylitol可被分类为多元醇和糖醇。

    Xylitol(Synonyms: 木糖醇; Xylite)

    Xylitol Chemical Structure

    CAS No. : 87-99-0

    规格 价格 是否有货 数量
    Free Sample (0.1-0.5 mg)   Apply now  
    10 mM * 1 mL in DMSO ¥550 In-stock
    100 mg ¥500 In-stock
    200 mg   询价  
    500 mg   询价  

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    Xylitol 相关产品

    相关化合物库:

    • Natural Product Library Plus
    • Drug Repurposing Compound Library Plus
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    • Children’s Drug Library

    生物活性

    Xylitol is a chemical categorized as a polyalcohol or sugar alcohol. Target: Others Xylitol is a chemical categorized as a polyalcohol or sugar alcohol (alditol). Xylitol has the formula (CHOH)3(CH2OH)2 and is an achiral isomer of pentane-1,2,3,4,5-pentol. Xylitol is used as a diabetic sweetener which is roughly as sweet as sucrose with 33% fewer calories. Unlike other natural or synthetic sweeteners, xylitol is actively beneficial for dental health by reducing caries to a third in regular use and helpful to remineralization. Xylitol is naturally found in low concentrations in the fibers of many fruits and vegetables, and can be extracted from various berries, oats, and mushrooms, as well as fibrous material such as corn husks and sugar cane bagasse and birch.

    IC50 & Target

    Human Endogenous Metabolite

     

    Clinical Trial

    分子量

    152.15

    Formula

    C5H12O5

    CAS 号

    87-99-0

    中文名称

    木糖醇

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 130 mg/mL (854.42 mM; Need ultrasonic)

    H2O : 110 mg/mL (722.97 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 6.5725 mL 32.8623 mL 65.7246 mL
    5 mM 1.3145 mL 6.5725 mL 13.1449 mL
    10 mM 0.6572 mL 3.2862 mL 6.5725 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 3.25 mg/mL (21.36 mM); Clear solution

      此方案可获得 ≥ 3.25 mg/mL (21.36 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 32.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 3.25 mg/mL (21.36 mM); Clear solution

      此方案可获得 ≥ 3.25 mg/mL (21.36 mM,饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例,取 100 μL 32.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
    • 3.

      请依序添加每种溶剂: 10% DMSO    90% corn oil

      Solubility: ≥ 3.25 mg/mL (21.36 mM); Clear solution

      此方案可获得 ≥ 3.25 mg/mL (21.36 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例,取 100 μL 32.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献
    • [1]. http://en.wikipedia.org/wiki/Xylitol

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