上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
EHT 1864 纯度: 99.85%
EHT 1864 是 Rac family small GTPases 的抑制剂。EHT 1864 直接结合并削弱了这种 small GTPase 与生长转化所需的关键下游效应器结合的能力。EHT 1864 结合 Rac1、Rac1b、Rac2 和 Rac3 的 Kd 值分别为 40、50、60 和 230 nM。EHT 1864 还对其它 Rac 依赖的转化过程,Tiam1 和 Ras 介导的生长转化有明显的抑制作用。EHT 1864 阻止体内 Aβ40 和 Aβ42 的产生。
EHT 1864 Chemical Structure
CAS No. : 754240-09-0
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1266 | In-stock | |
5 mg | ¥990 | In-stock | |
10 mg | ¥1430 | In-stock | |
50 mg | ¥6360 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
* Please select Quantity before adding items.
EHT 1864 相关产品
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生物活性 |
EHT 1864 is an inhibitor of Rac family small GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo[1][2][3]. |
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体内研究 (In Vivo) |
EHT 1864 (oral administration) displays good tolerability, brain penetrance, and no genotoxicity. EHT 1864 (10 and 40 mg/kg/day; daily; 15 days; intraperitoneal injections) lowers brain Aβ 40 by 37% in guinea pigs[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
581.48 |
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Formula |
C25H29Cl2F3N2O4S |
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CAS 号 |
754240-09-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
H2O : ≥ 100 mg/mL (171.97 mM) DMSO : ≥ 32 mg/mL (55.03 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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