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PhiKan 083 hydrochloride 纯度: ≥99.0%
PhiKan 083 hydrochloride 是一种咔唑衍生物,可以稳定 p53 的突变体 Y220C,Kd 值为 167 μM,在 Ln229 细胞中,相对亲和力 (Kd) 为 150 μM;PhiKan 083 可用于癌症研究。
PhiKan 083 hydrochloride Chemical Structure
CAS No. : 1050480-30-2
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥1000 | In-stock | |
5 mg | ¥1200 | In-stock | |
10 mg | 询价 | ||
50 mg | 询价 |
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生物活性 |
PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM[1], and a relative binding affinity (Kd) of 150 μM in Ln229 cells[3]. |
IC50 & Target |
Kd: 167 μM (p53-Y220C)[1], 150 μM (p53Y220C, in Ln229 cells)[3] |
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体外研究 (In Vitro) |
PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM[1], shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
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分子量 |
274.79 |
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Formula |
C16H19ClN2 |
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CAS 号 |
1050480-30-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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溶解性数据 |
In Vitro:
DMSO : 62.5 mg/mL (227.45 mM; ultrasonic and warming and heat to 60°C) H2O : 2 mg/mL (7.28 mM; Need ultrasonic and warming) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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