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INDY
INDY 是一种有效,ATP 竞争性的 Dyrk1A 和 Dyrk1B 抑制剂,IC50 分别为 0.24 μM 和 0.23 μM。INDY 结合在酶的 ATP 口袋中,对 Dyrk1A 的 Ki 值为 0.18 μM。INDY 大大降低了原代胶质母细胞瘤 (GBM) 细胞系和神经祖细胞中正常细胞和致瘤细胞的自我更新能力。
INDY Chemical Structure
CAS No. : 1169755-45-6
规格 | 价格 | 是否有货 | |
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5 mg | ¥2700 | 询问价格 & 货期 | |
10 mg | ¥4500 | 询问价格 & 货期 |
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生物活性 |
INDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC50s of 0.24 μM and 0.23 μM, respectively. INDY binds in the ATP pocket of the enzyme and has a Ki value of 0.18 μM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells[1][2]. |
IC50 & Target |
IC50: 0.24 μM (Dyrk1A) and 0.23 μM (Dyrk1B)[1] |
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体外研究 (In Vitro) |
INDY (0.3-30 μM; 20 hours) mildly inhibits tau-phosphorylation at 3 μM, and nearly completely inhibits at 30 μM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
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体内研究 (In Vivo) |
ProINDY (2.5 μM) recoveres apparently normal development of the Xenopus embryo[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
235.30 |
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Formula |
C12H13NO2S |
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CAS 号 |
1169755-45-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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参考文献 |
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