上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
IWP-O1 纯度: 99.61%
IWP-O1 是一个有效的 Porcn 抑制剂,在 L-Wnt-STF 细胞中的 EC50 值为 80 pM。IWP-O1 抑制 Wnt 蛋白分泌。IWP-O1 能够抑制 HeLa 细胞中 Dvl2/3 和 LRP6 磷酸化。
IWP-O1 Chemical Structure
CAS No. : 2074607-48-8
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1320 | In-stock | |
5 mg | ¥1200 | In-stock | |
10 mg | ¥2100 | In-stock | |
25 mg | ¥4500 | In-stock | |
50 mg | ¥8100 | In-stock | |
100 mg | ¥14500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
IWP-O1 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Stem Cell Signaling Compound Library
- Wnt/Hedgehog/Notch Compound Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
- Cytoskeleton Compound Library
- Neuroprotective Compound Library
- Anti-Breast Cancer Compound Library
生物活性 |
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells[1]. |
IC50 & Target |
EC50: 80 pM (Porcn)[1]. |
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体外研究 (In Vitro) |
IWP-O1 (17) suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM, 2.5 times more active than the investigational drug LGK974[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
432.48 |
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Formula |
C26H20N6O |
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CAS 号 |
2074607-48-8 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 125 mg/mL (289.03 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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