上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
ZINC05007751 纯度: 98.47%
ZINC05007751 是一种有效的 NIMA 相关激酶 NEK6 抑制剂,IC50 为 3.4 μM。ZINC05007751 对一组人类癌细胞系显示出抗增殖活性,并且在 BRCA2 突变的卵巢癌细胞系中显示出与顺铂和紫杉醇的协同效应。ZINC05007751 对 NEK1 和 NEK6 具有很强的选择性,但对 NEK2、NEK7 和 NEK9 没有明显的活性。
ZINC05007751 Chemical Structure
CAS No. : 591239-68-8
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥1500 | In-stock | |
10 mg | ¥2500 | In-stock | |
25 mg | ¥5500 | In-stock | |
50 mg | ¥9500 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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ZINC05007751 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Kinase Inhibitor Library
- Anti-Cancer Compound Library
生物活性 |
ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9[1]. |
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体外研究 (In Vitro) |
ZINC05007751 (6 μM-190 μM; 24 hours) inhibits the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15 with IC50 below 100 µM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity Assay[1]
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分子量 |
304.30 |
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Formula |
C18H12N2O3 |
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CAS 号 |
591239-68-8 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 8.33 mg/mL (27.37 mM; ultrasonic and warming and heat to 60°C) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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