L-Alanosine(Synonyms: 丙氨菌素; NSC-153353; SDX-102)

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L-Alanosine (Synonyms: 丙氨菌素; NSC-153353; SDX-102) 纯度: ≥95.0%

L-Alanosine (NSC-153353) 是来自 Streptomyces alanosinicus 的抗生素，具有抗肿瘤和抗病毒活性。L-Alanosine (NSC-153353) 抑制腺苷酸琥珀酸合成酶，将肌苷一磷酸 (IMP) 转化为腺苷酸琥珀酸。L-Alanosine (NSC-153353) 阻断常见的从头嘌呤生物合成途径，从而抑制具有 MTAP 缺陷的肿瘤细胞。

L-Alanosine(Synonyms: 丙氨菌素; NSC-153353; SDX-102)

L-Alanosine Chemical Structure

CAS No. : 5854-93-3

规格 价格 是否有货 数量
1 mg ￥1150 In-stock
5 mg ￥3400 In-stock
10 mg ￥5800 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

L-Alanosine 相关产品

•相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus

生物活性

L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine (NSC-153353) blocks the common de novo purine biosynthesis pathway and, thereby, inhibits tumor cells with MTAP deficiency[1][2][3].

Clinical Trial

分子量

149.11

Formula

C3H7N3O4
CAS 号

5854-93-3
中文名称

丙氨菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。
溶解性数据
In Vitro: 

H2O : 15 mg/mL (100.60 mM; ultrasonic and adjust pH to 8 with NaOH)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.7065 mL 33.5323 mL 67.0646 mL
5 mM 1.3413 mL 6.7065 mL 13.4129 mL
10 mM 0.6706 mL 3.3532 mL 6.7065 mL

*

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。
参考文献

  • [1]. Efferth T, et al. Identification of gene expression profiles predicting tumor cell response to L-alanosine. Biochem Pharmacol. 2003 Aug 15;66(4):613-21.

    [2]. Chitnis MP, et al. Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias. Tumori. 1984 Aug 31;70(4):317-20.

    [3]. Tyagi AK, et al. Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase. Cancer Res. 1980 Dec;40(12):4390-7.

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