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CRT0044876 纯度: 98.35%
CRT0044876 是一种高效、选择性的嘌呤/嘧啶核苷核酸内切酶 1 (APE1) 抑制剂,IC50 约为 3 μM。CRT0044876 可抑制 APE1 的 AP 内切酶、3′-磷酸二酯酶和 3′-磷酸酶活性,也是 APE1 所属的核酸外切酶 III 家族的特异性抑制剂。CRT0044876 增强了几种 DNA 碱基靶向化合物的细胞毒性。
![CRT0044876 Chemical Structure CRT0044876](http://www.fluoroprobe.com/wp-content/uploads/2022/05/hy-w014622.gif)
CRT0044876 Chemical Structure
CAS No. : 6960-45-8
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1100 | In-stock | |
50 mg | ¥1000 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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CRT0044876 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Cell Cycle/DNA Damage Compound Library
- Anti-Cancer Compound Library
- Anti-Aging Compound Library
- Targeted Diversity Library
生物活性 |
CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC50=~3 μM). CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds[1]. |
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体外研究 (In Vitro) |
A key step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP endonuclease. CRT0044876 has an IC50 for inhibition of APE1 of ∼3 μM and not only inhibits AP site cleavage catalyzed by purified APE1, but also cleavage directed by APE1 in a HeLa whole cell extract. CRT0044876 inhibits the 3′-phosphoglycolate diesterase activity of APE1 with an IC50 of ∼5 μM[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
206.15 |
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Formula |
C9H6N2O4 |
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CAS 号 |
6960-45-8 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (242.54 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic) (insoluble) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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