Dehydrocorydaline nitrate(Synonyms: 硝酸脱氢紫堇碱; 13-Methylpalmatine nitrate)

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Dehydrocorydaline nitrate (Synonyms: 硝酸脱氢紫堇碱; 13-Methylpalmatine nitrate) 纯度: 99.89%

Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) 是一种生物碱。Dehydrocorydaline 调节 Bax，Bcl-2 蛋白表达；激活 caspase-7，caspase-8，并使 PARP 失活。Dehydrocorydaline nitrate 能增强 p38 MAPK 活化，具有抗炎、抗癌等功效。。Dehydrocorydaline nitrate 具有强大的抗疟疾作用，并具低细胞毒性 (细胞生存力> 90％)， P. falciparum 3D7 strain (IC50=38 nM)。

Dehydrocorydaline nitrate(Synonyms: 硝酸脱氢紫堇碱; 13-Methylpalmatine nitrate)

Dehydrocorydaline nitrate Chemical Structure

CAS No. : 13005-09-9

规格 价格 是否有货 数量
5 mg ￥3360 In-stock
10 mg ￥5710 In-stock
50 mg   询价  
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生物活性

Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP[1]. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities.[2]. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain[3].

IC50 & Target

IC50: 38 nM (P. falciparum 3D7 strain)[3]
分子量

428.44

Formula

C22H24N2O7
CAS 号

13005-09-9
中文名称

硝酸脱氢紫堇碱；硝酸去氢紫堇碱；硝酸脱氢紫堇硷；硝酸脱氢延胡索碱；硝酸去氢延胡索碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Xu Z, et al. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85.

    [2]. Yoo M, et al. Dehydrocorydaline promotes myogenic differentiation via p38 MAPK activation. Mol Med Rep. 2016 Oct;14(4):3029-36.

    [3]. Nonaka M, et al. Screening of a library of traditional Chinese medicines to identify anti-malarial compounds and extracts. Malar J. 2018 Jun 25;17(1):244. doi: 10.1186/s12936-018-2392-4.

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