Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride

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Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride 

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride 结合了 E3 泛素连接酶的配体 cereblon (CRBN). Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride 可用于设计 PROTAC MD-224.

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride Chemical Structure

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生物活性

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312)[1].

IC50 & Target[1]

Cereblon

 

分子量

480.94

Formula

C25H25ClN4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466.

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