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| 名称 | Amyloid beta/A4 Protein Precursor770 (135- |
| 编码 | [315229-44-8] |
| 别名 | Amyloid beta/A4 Protein Precursor770 (135- |
| 纯度 | 80%，90%，95%，98%，99% |
| 重量 | 1mg,5mg,10mg,50mg,100mg,1g |
| 序列（单字母缩写） | FLHQERMDVCETHLHWHTVAK |
| 序列（三字母缩写） | H-Phe-Leu-His-Gln-Glu-Arg-Met-Asp-Val-Cys-Glu-Thr-His-Leu-His-Trp-His-Thr-Val-Ala-Lys-OH (trifluoroacetate salt) |
| 基本描述 | This peptide is the C-terminal fragment of amyloid precursor protein (APP) also known as C31. It is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer’s disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid beta-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid beta-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis. |
| 溶解度 | |
| 分子量 | 2618 |
| 化学式 | C116H173N35O31S2 |
| 存储条件 | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| 注释 | |
| Documents | ![Amyloid beta/A4 Protein Precursor770 (135- 编码 [315229-44-8]](http://www.fluoroprobe.com/wp-content/uploads/2022/10/20221013_634880b355d13.png) |
| Figures | ![Amyloid beta/A4 Protein Precursor770 (135- 编码 [315229-44-8]](http://www.fluoroprobe.com/wp-content/uploads/2022/10/20221013_634880b3a8c5a.jpg) |
| Reference | G.Multhaup et al., Science, 271, 1406 (1996) |
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