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名称 | [Lys(Ac)373]-p53 (368-393), p53 K373(Ac), biotin-labeled, human |
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别名 | [Lys(Ac)373]-p53 (368-393), p53 K373(Ac), biotin-labeled, human |
纯度 | 80%,90%,95%,98%,99% |
重量 | 1mg,5mg,10mg,50mg,100mg,1g |
序列(单字母缩写) | Biotin-KGGHLKSK-K(Ac)-GQSTSRHKKLMFKTEGPDSD-NH2 |
序列(三字母缩写) | Biotin-Lys-Gly-Gly-His-Leu-Lys-Ser-Lys-Lys(Ac)-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2(trifluoroacetate salt) |
基本描述 | This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with acetylation at Lys373 and additional KGW residues on its N-terminus. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo. |
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分子量 | 3481 |
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存储条件 | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
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Reference | Kanovsky, M. et al. Proc Natl Acad Sci 98, 12438 (2001) |
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