Jasplakinolide

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Jasplakinolide 

Jasplakinolide 是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂，可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白，Kd 值为 15 nM。Jasplakinolide 是一种来自海洋海绵 (marine sponge) 的天然环状肽，具有抗真菌和抗肿瘤活性。

Jasplakinolide

Jasplakinolide Chemical Structure

CAS No. : 102396-24-7

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生物活性

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].

体外研究
(In Vitro)

Jasplakinolide has an IC50 of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells[2].
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites[2].
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

709.67

Formula

C36H45BrN4O6
CAS 号

102396-24-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27;269(21):14869-71.

    [2]. Holzinger A, et al. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol. 2009;586:71-87.

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