标签归档：jasplakinolide

Jasplakinolide

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Jasplakinolide 

Jasplakinolide 是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂，可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白，Kd 值为 15 nM。Jasplakinolide 是一种来自海洋海绵 (marine sponge) 的天然环状肽，具有抗真菌和抗肿瘤活性。

Jasplakinolide

Jasplakinolide Chemical Structure

CAS No. : 102396-24-7

规格 价格 是否有货
100 μg ￥12000 询问价格 & 货期

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生物活性

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].

体外研究
(In Vitro)

Jasplakinolide has an IC50 of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells[2].
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites[2].
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

709.67

Formula

C36H45BrN4O6
CAS 号

102396-24-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27;269(21):14869-71.

    [2]. Holzinger A, et al. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol. 2009;586:71-87.

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Cas(102396-24-7), Jasplakinolide, ,Jasplakinolide,

发表于由

茉莉花内酯

肌动蛋白聚合和稳定诱导剂。细胞可渗透的。
≥97% (HPLC)

有货

Cas(102396-24-7), Jasplakinolide,  ,Jasplakinolide,

CAS编号 102396-24-7 | 品牌：Jinpan
Jasplakinolide

MSDS

质检证书(CoA)

相似产品

  • 分子式 C36H45BrN4O6
  • 分子量709.67
  • MDL号 MFCD00873735
  • PubChem编号 134689754

货号 (SKU) 包装规格 是否现货 价格 数量
J132593-100μg 100μg 现货 Cas(102396-24-7), Jasplakinolide,  ,Jasplakinolide,  

基本信息

产品名称 茉莉花内酯
英文名称 Jasplakinolide
别名 Jaspamide
英文别名 NSC 613009; cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-8S-hydroxy-2S,4E,6R-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]
规格或纯度 ≥97% (HPLC)
运输条件 超低温冰袋运输
生化机理 Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. In vitro, Jasplakinolidet potently induces actin polymerization by stimulating actin filament nucleation and competes with phalloidin for actin binding (Kd = 15 nM). In vivo, Jasplakinolide has been found to disrupt actin filaments and induce polymerization of monomeric actin into amorphous masses, the exact mechanism of which has not been determined yet. Jasplakinolide differs from other actin stabilizers in that it is cell permeable. This peptide has fungicidal, insecticidal and antiproliferative activity, and is useful for investigating cell processes mediated by actin polymerization and depolymerization, such as cell adhesion, locomotion, endocytosis, and vesicle sorting and release.Cell-permeable actin polymerization and stabilization inducer. Potent antiproliferative activity (IC 50 = 15 nM). Antitumor and antifungal agent. Active in vitro .

一般描述

A cell permeable compound which stabilizes pre-formed actin filaments and inhibits their disassembly.

A cell permeable compound which stabilizes pre-formed actin filaments and inhibits their disassembly.

相关属性

CAS编号 102396-24-7
敏感性 对光敏感
溶解性 Soluble in DMSO (>2 mg/ml), water (partly), 100% ethanol, and 83% methanol
储存温度 避光,-20°C储存
RTECS GX7000000
MDL号 MFCD00873735
分子量 709.67
分子式 C36H45BrN4O6
品牌 Jinpan
备注 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
PubChem CID 134689754