Stilbamidine(Synonyms: 司替巴脒; Ba 2652; Stilbamidin)

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Stilbamidine (Synonyms: 司替巴脒; Ba 2652; Stilbamidin)

Stilbamidine 是 Stilbene 衍生的二脒化合物,主要以其羟乙基磺酸盐形式发挥作用,用于抑制各种真菌感染。

Stilbamidine(Synonyms: 司替巴脒; Ba 2652;  Stilbamidin)

Stilbamidine Chemical Structure

CAS No. : 122-06-5

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生物活性

Stilbamidine is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.

IC50 & Target

fungal

体外研究
(In Vitro)

The high-affinity pentamidine transporter (HAPT1) is inhibited by Propamidine but displays only low affinity to Stilbamidine. adenosine-sensitive pentamidine transporter (ASPT1), in contrast, is strongly inhibited by Stilbamidine, and Propamidine. [3H]pentamidine uptake is determined in the presence of various concentrations of adenosine (IC50=1.2 μM) or melarsen oxide (IC50=0.7 μM), as well as in the presence of 250 μM adenosine and increasing concentrations of hypoxanthine, Propamidine (IC50=6.1 μM) and Stilbamidine (IC50=110 μM)[1]. The two diamidine compounds, Stilbamidine and Pentamidine are used to treat in multiple myeloma, a disease in which increase of the globulin content of the serum is of frequent occurrence[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

264.33

Formula

C16H16N4

CAS 号

122-06-5

中文名称

司替巴脒

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. De Koning HP. Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals. Mol Pharmacol. 2001 Mar;59(3):586-92.

    [2]. BREWER AE.et al. Multiple myeloma treated with stilbamidine and pentamidine. Br Med J. 1948 Dec 4;2(4587):978-82.

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