上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Anagrelide
Anagrelide是一种III型磷酸二酯酶(PDEIII)抑制剂 (IC50=36 nM),抑制血小板生成。Anagrelide 是一种咪唑喹唑啉衍生物,可作为血小板聚集抑制剂。Anagrelide 具有抗血栓形成作用。
Anagrelide Chemical Structure
CAS No. : 68475-42-3
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Anagrelide 的其他形式现货产品:
生物活性 |
Anagrelide, an inhibitor of phosphodiesterase type III (PDEIII) (IC50=36 nM), inhibits platelet production. Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide plays in the antithrombopoietic action. The platelet-lowering agent[1]. |
IC50 & Target |
PDEIII[1] |
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体外研究 (In Vitro) |
Anagrelide potently inhibits the development of marrow megakaryocytes (IC50=26 nM)[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
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体内研究 (In Vivo) |
Anagrelide is effective in a GIST xenograft mouse model with KIT exon 9 mutation that may pose a therapeutic challenge, as these GISTs require a high daily dose of Imatinib[3]. Anagrelide inhibits GIST growth in patient-derived mouse xenograft models. Anagrelide has therapeutic value in the treatment of GIST. Anagrelide has antitumoral activity in GIST xenograft models[3]. Anagrelide (5 mg/kg/bid) inhibits or reduces tumor growth in GIST2B, GIST9, GIST882 model models[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
256.09 |
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Formula |
C10H7Cl2N3O |
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CAS 号 |
68475-42-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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