I-PEG5-OH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

I-PEG5-OH 

I-PEG5-OH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

I-PEG5-OH

I-PEG5-OH Chemical Structure

CAS No. : 1883516-31-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

I-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

348.18

Formula

C10H21IO5

CAS 号

1883516-31-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

I-PEG6-OH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

I-PEG6-OH 

I-PEG6-OH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

I-PEG6-OH

I-PEG6-OH Chemical Structure

CAS No. : 136399-07-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

I-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

392.23

Formula

C12H25IO6

CAS 号

136399-07-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Ph-PEG3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ph-PEG3 

Ph-PEG3 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Ph-PEG3

Ph-PEG3 Chemical Structure

CAS No. : 7204-16-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

226.27

Formula

C12H18O4

CAS 号

7204-16-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Seph-PAO

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Seph-PAO 

Seph-PAO 是连接sepharose 荧光基团的 PAO,可用于检测硫氧还蛋白还原酶 (TrxR)。

Seph-PAO

Seph-PAO Chemical Structure

CAS No. : 851461-65-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Seph-PAO is the modified PAO attached a sepharose fluorophore and is used to detect the thioredoxin reductase (TrxR)[1].

CAS 号

851461-65-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dongzhu Duan, et al. Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells. J Biol Chem. 2016 May 6;291(19):10021-31.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

I-PEG5-OH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

I-PEG5-OH 

I-PEG5-OH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

I-PEG5-OH

I-PEG5-OH Chemical Structure

CAS No. : 1883516-31-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

I-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

348.18

Formula

C10H21IO5

CAS 号

1883516-31-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Ph-PEG3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ph-PEG3 

Ph-PEG3 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Ph-PEG3

Ph-PEG3 Chemical Structure

CAS No. : 7204-16-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

226.27

Formula

C12H18O4

CAS 号

7204-16-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

FTISADTSK

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

FTISADTSK 

FTISADTSK 是一种内源性稳定的曲妥珠单抗信号肽,由 SRM 监测得到。

FTISADTSK

FTISADTSK Chemical Structure

CAS No. : 1431957-73-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

FTISADTSK 的其他形式现货产品:

FTISADTSK acetate

生物活性

FTISADTSK is an endogenous stable signature peptide from Trastuzumab monitored by selected reaction monitoring (SRM)[1].

分子量

969.05

Formula

C42H68N10O16

CAS 号

1431957-73-1

Sequence Shortening

FTISADTSK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bults P, et al. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Anal Chem. 2016;88(3):1871-1877.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

F-PEG2-S-Boc

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

F-PEG2-S-Boc 

F-PEG2-S-Boc 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

F-PEG2-S-Boc

F-PEG2-S-Boc Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

F-PEG2-S-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

282.37

Formula

C12H23FO4S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. “An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. “

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

DBCO-S-S-acid

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

DBCO-S-S-acid 

DBCO-S-S-acid 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

DBCO-S-S-acid

DBCO-S-S-acid Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

DBCO-S-S-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

468.59

Formula

C24H24N2O4S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PAO-Nap

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PAO-Nap 

PAO-Nap 是NAP (naphthalimide) 荧光基团修饰的 PAO。PAO 通过选择性靶向硫氧蛋白还原酶诱导 HL-60 细胞氧化应激介导的凋亡。

PAO-Nap

PAO-Nap Chemical Structure

CAS No. : 1613402-20-2

规格 价格 是否有货
5 mg ¥3000 询问价格 & 货期
10 mg ¥4800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1].

体外研究
(In Vitro)

PAO exhibits IC50 values of 6.2 μM, 9.4 μM, 7.7 μM in HL-60, 7721 and Hela cells (48 h)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

509.39

Formula

C24H24AsN3O5

CAS 号

1613402-20-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yaping Liu, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PLK4-IN-3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PLK4-IN-3 

PLK4-IN-3 是PLK4-IN-1 的绝对构型。PLK4-IN-1 (Example A6) 是PLK4 的抑制剂,其IC50 值为 ≤0.1 μM。

PLK4-IN-3

PLK4-IN-3 Chemical Structure

CAS No. : 1247001-86-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PLK4-IN-3 is a less active absolute stereochemistry of PLK4-IN-1. PLK4-IN-1 is a PLK4 inhibitor, with an IC50 of 0.65 μM[1].

IC50 & Target[1]

PLK4

≤ 0.1 μM (IC50)

分子量

431.23

Formula

C18H14IN3O2

CAS 号

1247001-86-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Peter Brent Sampson, et al. KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME. Patent. WO2011123946A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PLK4-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PLK4-IN-1 

PLK4-IN-1 (Example A6) 是 PLK4 的抑制剂,其 IC50 值为 ≤ 0.1 μM。

PLK4-IN-1

PLK4-IN-1 Chemical Structure

CAS No. : 1247001-12-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PLK4-IN-1 (Example A6) is a PLK4 inhibitor, with an IC50 of ≤ 0.1 μM[1].

IC50 & Target

IC50: ≤ 0.1 μM (PLK4)[1].

分子量

431.23

Formula

C18H14IN3O2

CAS 号

1247001-12-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Peter Brent Sampson, et al. KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME. Patent. WO2011123946A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PAO-Nap

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PAO-Nap 

PAO-Nap 是NAP (naphthalimide) 荧光基团修饰的 PAO。PAO 通过选择性靶向硫氧蛋白还原酶诱导 HL-60 细胞氧化应激介导的凋亡。

PAO-Nap

PAO-Nap Chemical Structure

CAS No. : 1613402-20-2

规格 价格 是否有货
5 mg ¥3000 询问价格 & 货期
10 mg ¥4800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[1].

体外研究
(In Vitro)

PAO exhibits IC50 values of 6.2 μM, 9.4 μM, 7.7 μM in HL-60, 7721 and Hela cells (48 h)[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

509.39

Formula

C24H24AsN3O5

CAS 号

1613402-20-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yaping Liu, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PLK4-IN-3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PLK4-IN-3 

PLK4-IN-3 是PLK4-IN-1 的绝对构型。PLK4-IN-1 (Example A6) 是PLK4 的抑制剂,其IC50 值为 ≤0.1 μM。

PLK4-IN-3

PLK4-IN-3 Chemical Structure

CAS No. : 1247001-86-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PLK4-IN-3 is a less active absolute stereochemistry of PLK4-IN-1. PLK4-IN-1 is a PLK4 inhibitor, with an IC50 of 0.65 μM[1].

IC50 & Target[1]

PLK4

≤ 0.1 μM (IC50)

分子量

431.23

Formula

C18H14IN3O2

CAS 号

1247001-86-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Peter Brent Sampson, et al. KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME. Patent. WO2011123946A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

CH2COOH-PEG3-CH2COOH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CH2COOH-PEG3-CH2COOH 

CH2COOH-PEG3-CH2COOH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

CH2COOH-PEG3-CH2COOH

CH2COOH-PEG3-CH2COOH Chemical Structure

CAS No. : 32775-08-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CH2COOH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

266.25

Formula

C10H18O8

CAS 号

32775-08-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PLK4-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PLK4-IN-1 

PLK4-IN-1 (Example A6) 是 PLK4 的抑制剂,其 IC50 值为 ≤ 0.1 μM。

PLK4-IN-1

PLK4-IN-1 Chemical Structure

CAS No. : 1247001-12-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PLK4-IN-1 (Example A6) is a PLK4 inhibitor, with an IC50 of ≤ 0.1 μM[1].

IC50 & Target

IC50: ≤ 0.1 μM (PLK4)[1].

分子量

431.23

Formula

C18H14IN3O2

CAS 号

1247001-12-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Peter Brent Sampson, et al. KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME. Patent. WO2011123946A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Seph-PAO

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Seph-PAO 

Seph-PAO 是连接sepharose 荧光基团的 PAO,可用于检测硫氧还蛋白还原酶 (TrxR)。

Seph-PAO

Seph-PAO Chemical Structure

CAS No. : 851461-65-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Seph-PAO is the modified PAO attached a sepharose fluorophore and is used to detect the thioredoxin reductase (TrxR)[1].

CAS 号

851461-65-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dongzhu Duan, et al. Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells. J Biol Chem. 2016 May 6;291(19):10021-31.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

FTISADTSK

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

FTISADTSK 

FTISADTSK 是一种内源性稳定的曲妥珠单抗信号肽,由 SRM 监测得到。

FTISADTSK

FTISADTSK Chemical Structure

CAS No. : 1431957-73-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

FTISADTSK 的其他形式现货产品:

FTISADTSK acetate

生物活性

FTISADTSK is an endogenous stable signature peptide from Trastuzumab monitored by selected reaction monitoring (SRM)[1].

分子量

969.05

Formula

C42H68N10O16

CAS 号

1431957-73-1

Sequence Shortening

FTISADTSK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bults P, et al. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Anal Chem. 2016;88(3):1871-1877.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Seph-PAO

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Seph-PAO 

Seph-PAO 是连接sepharose 荧光基团的 PAO,可用于检测硫氧还蛋白还原酶 (TrxR)。

Seph-PAO

Seph-PAO Chemical Structure

CAS No. : 851461-65-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Seph-PAO is the modified PAO attached a sepharose fluorophore and is used to detect the thioredoxin reductase (TrxR)[1].

CAS 号

851461-65-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dongzhu Duan, et al. Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells. J Biol Chem. 2016 May 6;291(19):10021-31.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

F-PEG2-S-Boc

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

F-PEG2-S-Boc 

F-PEG2-S-Boc 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

F-PEG2-S-Boc

F-PEG2-S-Boc Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

F-PEG2-S-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

282.37

Formula

C12H23FO4S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. “An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. “

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务