标签归档：mg

AKT-IN-11

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AKT-IN-11 

AKT-IN-11 是抗人肝癌Bel-7402细胞株最有效的抗菌剂之一，其IC501.15μM。

AKT-IN-11

AKT-IN-11 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

AKT-IN-11 is one of the most effective antibacterial agents against human hepatoma BEL-7402 cell line with an IC50 value of 1.15μM.

IC50 & Target

AKT,ERK

1.15 μM (IC50)

分子量

521.96

Formula

C27H27ClF3NO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hai Y,et al. Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma. Eur J Med Chem. 2022 Feb 5;232:114166.

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Penicitide A

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Penicitide A 

Penicitide A 是一种海洋次生代谢产物。Penicitide A 对病原体 A.brassicae和人肝细胞肝癌 (HepG2) 细胞系显示中度细胞毒性。

Penicitide A

Penicitide A Chemical Structure

CAS No. : 1338332-27-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Penicitide A is a marine secondary metabolite. Penicitide A shows moderate cytotoxicity against pathogen A. brassicae and the human hepatocellular liver carcinoma (HepG2) cell line[1].

IC50 & Target[1]

Microbial Metabolite

 

分子量

314.46

Formula

C18H34O4
CAS 号

1338332-27-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Saha D, et al. Total Synthesis and Stereochemical Assignment of Penicitide A. Org Lett. 2020;22(2):745-749.

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Mal-Deferoxamine

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Mal-Deferoxamine 

Mal-Deferoxamine 是构建 RDC 的接头。

Mal-Deferoxamine

Mal-Deferoxamine Chemical Structure

CAS No. : 1638156-31-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Mal-Deferoxamine is the linker for construct RDC[1].

分子量

711.80

Formula

C32H53N7O11
CAS 号

1638156-31-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Summer D, et al. Cyclic versus Noncyclic Chelating Scaffold for 89Zr-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression. Mol Pharm. 2018;15(1):175-185.

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Maximiscin

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Maximiscin 

Maximiscin是一种真菌代谢产物，可诱导 DNA damage 损伤，并对一种三阴性乳腺癌亚型显示出选择性的细胞毒活性。

Maximiscin

Maximiscin Chemical Structure

CAS No. : 1612154-44-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Maximiscin, a fungal metabolite, induces DNA damage and shows selective cytotoxic activity against a subtype of triple-negative breast cancer.

分子量

449.49

Formula

C23H31NO8
CAS 号

1612154-44-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Robles AJ, et al. Maximiscin Induces DNA Damage, Activates DNA Damage Response Pathways, and Has Selective Cytotoxic Activity against a Subtype of Triple-Negative Breast Cancer. J Nat Prod. 2016 Jul 22;79(7):1822-7.

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ZY-444

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ZY-444 

ZY-444是一种通过靶向丙酮酸羧化酶抑制乳腺癌进展的小分子。

ZY-444

ZY-444 Chemical Structure

CAS No. : 1802650-31-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ZY-444 is a small molecule that suppresses breast cancer progression by targeting pyruvate carboxylase.

分子量

444.59

Formula

C26H28N4OS
CAS 号

1802650-31-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lin Q, et al. Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. Adv Sci (Weinh). 2020 Mar 12;7(9):1903483.

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Mal-Deferoxamine

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Mal-Deferoxamine 

Mal-Deferoxamine 是构建 RDC 的接头。

Mal-Deferoxamine

Mal-Deferoxamine Chemical Structure

CAS No. : 1638156-31-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Mal-Deferoxamine is the linker for construct RDC[1].

分子量

711.80

Formula

C32H53N7O11
CAS 号

1638156-31-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Summer D, et al. Cyclic versus Noncyclic Chelating Scaffold for 89Zr-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression. Mol Pharm. 2018;15(1):175-185.

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Indolokine A4

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Indolokine A4 

Indolokine A4, 吲哚-3-丙酮酸 (I3P) 的分解代谢物, 是一种有效的 AhR 激动剂。

Indolokine A4

Indolokine A4 Chemical Structure

CAS No. : 1809317-07-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Indolokine A4, a catabolite of indole-3-pyruvate (I3P), is a potent AhR agonist[1].

IC50 & Target

AhR[1]
分子量

274.30

Formula

C13H10N2O3S
CAS 号

1809317-07-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gatsios A, et, al. Escherichia coli small molecule metabolism at the host-microorganism interface. Nat Chem Biol. 2021 Oct;17(10):1016-1026.

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Penicitide A

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Penicitide A 

Penicitide A 是一种海洋次生代谢产物。Penicitide A 对病原体 A.brassicae和人肝细胞肝癌 (HepG2) 细胞系显示中度细胞毒性。

Penicitide A

Penicitide A Chemical Structure

CAS No. : 1338332-27-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Penicitide A is a marine secondary metabolite. Penicitide A shows moderate cytotoxicity against pathogen A. brassicae and the human hepatocellular liver carcinoma (HepG2) cell line[1].

IC50 & Target[1]

Microbial Metabolite

 

分子量

314.46

Formula

C18H34O4
CAS 号

1338332-27-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Saha D, et al. Total Synthesis and Stereochemical Assignment of Penicitide A. Org Lett. 2020;22(2):745-749.

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Indolokine A5

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Indolokine A5 

Indolokine A5, L-半胱氨酸的分解代谢物, 是一种有效的 AhR 激动剂。

Indolokine A5

Indolokine A5 Chemical Structure

CAS No. : 951207-88-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Indolokine A5, a catabolite of L-cysteine, is a potent AhR agonist[1].

IC50 & Target

AhR[1]
分子量

272.28

Formula

C13H8N2O3S
CAS 号

951207-88-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gatsios A, et, al. Escherichia coli small molecule metabolism at the host-microorganism interface. Nat Chem Biol. 2021 Oct;17(10):1016-1026.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Maximiscin

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Maximiscin 

Maximiscin是一种真菌代谢产物，可诱导 DNA damage 损伤，并对一种三阴性乳腺癌亚型显示出选择性的细胞毒活性。

Maximiscin

Maximiscin Chemical Structure

CAS No. : 1612154-44-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Maximiscin, a fungal metabolite, induces DNA damage and shows selective cytotoxic activity against a subtype of triple-negative breast cancer.

分子量

449.49

Formula

C23H31NO8
CAS 号

1612154-44-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Robles AJ, et al. Maximiscin Induces DNA Damage, Activates DNA Damage Response Pathways, and Has Selective Cytotoxic Activity against a Subtype of Triple-Negative Breast Cancer. J Nat Prod. 2016 Jul 22;79(7):1822-7.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

BIM-26226

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BIM-26226 

BIM-26226 是一种胃泌素释放肽，是一种强效选择性的 bombesin receptor 拮抗剂。 BIM-26226 抑制 BN 或 GRP 刺激的淀粉酶释放，IC50 值在纳摩尔范围内。BIM-26226 可用于癌症研究。

BIM-26226

BIM-26226 Chemical Structure

CAS No. : 136207-23-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

BIM-26226, gastrin-releasing peptide, is a potent and selective antagonist of bombesin receptor. BIM-26226 inhibits BN- or GRP-stimulated amylase release with IC50s in the nanomolar range. BIM-26226 can be used for the research of cancer[1][2].

IC50 & Target

bombesin receptor[1]
分子量

1075.09

Formula

C49H63F5N12O10
CAS 号

136207-23-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Dietrich JB, et, al. Effects of BIM26226, a potent and specific bombesin receptor antagonist, on amylase release and binding of bombesin-like peptides to AR4-2J cells. Regul Pept. 1994 Oct 21;53(3):165-73.

    [2]. Damgé C, et, al. Effect of the gastrin-releasing peptide antagonist BIM 26226 and lanreotide on an acinar pancreatic carcinoma. Eur J Pharmacol. 1998 Apr 17;347(1):77-86.

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ZY-444

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ZY-444 

ZY-444是一种通过靶向丙酮酸羧化酶抑制乳腺癌进展的小分子。

ZY-444

ZY-444 Chemical Structure

CAS No. : 1802650-31-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ZY-444 is a small molecule that suppresses breast cancer progression by targeting pyruvate carboxylase.

分子量

444.59

Formula

C26H28N4OS
CAS 号

1802650-31-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lin Q, et al. Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. Adv Sci (Weinh). 2020 Mar 12;7(9):1903483.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Stephacidin B

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Stephacidin B 

Stephacidin B是一种真菌代谢物。Stephacidin B 对一组人类肿瘤细胞系显示出体外细胞毒性。Stephacidin B 对睾酮依赖性前列腺 LNCaP 癌细胞具有最强的细胞毒性。

Stephacidin B

Stephacidin B Chemical Structure

CAS No. : 360765-75-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Stephacidin B is a fungal metabolite. Stephacidin B shows in vitro cytotoxicity against a panel of human tumor cell lines. Stephacidin B shows the strongest cytotoxicity against testosterone-dependent prostate LNCaP cancer cells[1].

IC50 & Target[1]

Microbial Metabolite

 

分子量

891.02

Formula

C52H54N6O8
CAS 号

360765-75-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. von Nussbaum F. Stephacidin B-A new stage of complexity within prenylated indole alkaloids from fungi. Angew Chem Int Ed Engl. 2003;42(27):3068-3071.

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Penicitide A

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Penicitide A 

Penicitide A 是一种海洋次生代谢产物。Penicitide A 对病原体 A.brassicae和人肝细胞肝癌 (HepG2) 细胞系显示中度细胞毒性。

Penicitide A

Penicitide A Chemical Structure

CAS No. : 1338332-27-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Penicitide A is a marine secondary metabolite. Penicitide A shows moderate cytotoxicity against pathogen A. brassicae and the human hepatocellular liver carcinoma (HepG2) cell line[1].

IC50 & Target[1]

Microbial Metabolite

 

分子量

314.46

Formula

C18H34O4
CAS 号

1338332-27-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Saha D, et al. Total Synthesis and Stereochemical Assignment of Penicitide A. Org Lett. 2020;22(2):745-749.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Indolokine A4

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Indolokine A4 

Indolokine A4, 吲哚-3-丙酮酸 (I3P) 的分解代谢物, 是一种有效的 AhR 激动剂。

Indolokine A4

Indolokine A4 Chemical Structure

CAS No. : 1809317-07-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Indolokine A4, a catabolite of indole-3-pyruvate (I3P), is a potent AhR agonist[1].

IC50 & Target

AhR[1]
分子量

274.30

Formula

C13H10N2O3S
CAS 号

1809317-07-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gatsios A, et, al. Escherichia coli small molecule metabolism at the host-microorganism interface. Nat Chem Biol. 2021 Oct;17(10):1016-1026.

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Aspericin C

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Aspericin C 

Aspericin C 是一种吡喃衍生物，存在于海洋真菌根霉 2-PDA-61 中。Aspericin C 对 P388、A549、HL-60 和 BEL-7420 细胞系 (IC50 分别为14.6、7.1、61.4 和 24.2 μM) 显示出细胞毒性活性。

Aspericin C

Aspericin C Chemical Structure

CAS No. : 1216840-17-3

规格 是否有货
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生物活性

Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC50=14.6, 7.1, 61.4, and 24.2 μM, respectively)[1].

IC50 & Target[1]

Microbial Metabolite

 

分子量

298.42

Formula

C17H30O4
CAS 号

1216840-17-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wang F, et al. Structural determination of aspericins A-C, new furan and pyran derivates from the marine-derived fungus Rhizopus sp. 2-PDA-61, by 1D and 2D NMR spectroscopy. Magn Reson Chem. 2010;48(2):155-158.

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Indolokine A5

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Indolokine A5 

Indolokine A5, L-半胱氨酸的分解代谢物, 是一种有效的 AhR 激动剂。

Indolokine A5

Indolokine A5 Chemical Structure

CAS No. : 951207-88-8

规格 是否有货
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生物活性

Indolokine A5, a catabolite of L-cysteine, is a potent AhR agonist[1].

IC50 & Target

AhR[1]
分子量

272.28

Formula

C13H8N2O3S
CAS 号

951207-88-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gatsios A, et, al. Escherichia coli small molecule metabolism at the host-microorganism interface. Nat Chem Biol. 2021 Oct;17(10):1016-1026.

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Maximiscin

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Maximiscin 

Maximiscin是一种真菌代谢产物，可诱导 DNA damage 损伤，并对一种三阴性乳腺癌亚型显示出选择性的细胞毒活性。

Maximiscin

Maximiscin Chemical Structure

CAS No. : 1612154-44-5

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生物活性

Maximiscin, a fungal metabolite, induces DNA damage and shows selective cytotoxic activity against a subtype of triple-negative breast cancer.

分子量

449.49

Formula

C23H31NO8
CAS 号

1612154-44-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Robles AJ, et al. Maximiscin Induces DNA Damage, Activates DNA Damage Response Pathways, and Has Selective Cytotoxic Activity against a Subtype of Triple-Negative Breast Cancer. J Nat Prod. 2016 Jul 22;79(7):1822-7.

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YF479

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YF479 

YF479 是一种有效的组蛋白去乙酰化酶 (histone deacetylase) 抑制剂。YF479 降低细胞活力，抑制集落形成和肿瘤细胞运动。YF479 显着抑制乳腺肿瘤的生长和转移。YF479具有乳腺癌临床试验研究的潜力。

YF479

YF479 Chemical Structure

CAS No. : 1803281-22-2

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生物活性

YF479 is a potent inhibitor of histone deacetylase. YF479 abates cell viability, suppresses colony formation and tumor cell motility. YF479 significantly inhibits breast tumor growth and metastasis. YF479 has the potential for the research of clinical trials for breast cancer[1].

分子量

479.36

Formula

C22H27BrN2O5
CAS 号

1803281-22-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang T, et al. Antitumor action of a novel histone deacetylase inhibitor, YF479, in breast cancer. Neoplasia. 2014 Aug;16(8):665-77.

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BIM-26226

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BIM-26226 

BIM-26226 是一种胃泌素释放肽，是一种强效选择性的 bombesin receptor 拮抗剂。 BIM-26226 抑制 BN 或 GRP 刺激的淀粉酶释放，IC50 值在纳摩尔范围内。BIM-26226 可用于癌症研究。

BIM-26226

BIM-26226 Chemical Structure

CAS No. : 136207-23-3

规格 是否有货
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生物活性

BIM-26226, gastrin-releasing peptide, is a potent and selective antagonist of bombesin receptor. BIM-26226 inhibits BN- or GRP-stimulated amylase release with IC50s in the nanomolar range. BIM-26226 can be used for the research of cancer[1][2].

IC50 & Target

bombesin receptor[1]
分子量

1075.09

Formula

C49H63F5N12O10
CAS 号

136207-23-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Dietrich JB, et, al. Effects of BIM26226, a potent and specific bombesin receptor antagonist, on amylase release and binding of bombesin-like peptides to AR4-2J cells. Regul Pept. 1994 Oct 21;53(3):165-73.

    [2]. Damgé C, et, al. Effect of the gastrin-releasing peptide antagonist BIM 26226 and lanreotide on an acinar pancreatic carcinoma. Eur J Pharmacol. 1998 Apr 17;347(1):77-86.

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