IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC₅₀s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity^[1].

IDO1-IN-2 inhibits amino-cyclobutarene-derived indoleamine-2,3-dioxygenase 1 (IDO1) Hela cellular with an IC₅₀ of 49 nM. IDO1-IN-2 has an IC₅₀ of 249 nM for IDO1 wholr blood^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

IDO1-IN-2 (100 mg/kg, twice daily) demonstrates good efficacy synergy when combined with anti-PD-1 mAb in a mouse EMT6 tumor syngeneic model^[1].
IDO1-IN-2 has a t_1/2 of 3.7 hours, a CL/CLu of 15/319 mL/min/kg, and a F of 63% for rats. IDO1-IN-2 has a t_1/2 of 6 hours, a CL/CLu of 6/88 mL/min/kg, and a F of 67% for dogs^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

364.33

C₁₅H₁₇FN₆O₄

2346614-58-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang H, et al.Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.ACS Med Chem Lett. 2019 Sep 18;10(11):1530-1536.