Antiproliferative against-5 (compound 2y) has excellent anti-proliferative activity against certain cancer cell lines. Antiproliferative against-5 reduces the mitochondrial membrane potential, and increases the apoptosis rate and the level of ROS on EC109. Antiproliferative against-5 inhibits tumour growth in nude mice, with low toxicity^[1].

IC₅₀: 0.13 ± 0.01 μM in EC109, 0.27 ± 0.02 μM in TE-1, 0.20 ± 0.01 μM in MGC-803, 0.35 ± 0.03 μM in MCF-7^[1]

Antiproliferative against-5 has inhibitory activity against cancer cell lines EC109, TE-1, MGC-803 and MCF-7 with IC₅₀s of 0.13 ± 0.01 μM, 0.27 ± 0.02 μM, 0.20 ± 0.01 μM and 0.35 ± 0.03 μM^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

547.04

C₂₉H₃₅ClO₈

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Huo JF, et al. Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents. Eur J Med Chem. 2020;208:112789.