上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
SZL P1-41 纯度: ≥98.0%
SZL P1-41 是一种特异的 Skp2 抑制剂,结合在 Skp2 的 F-box 域以防止与 Skp1 关联和 Skp2 SCF 复合物形成。与 Skp2 缺乏一样,SZL P1-41 增加 p27 介导的凋亡/衰老,同时损害 Akt 驱动的糖酵解。具有抗肿瘤活性。
SZL P1-41 Chemical Structure
CAS No. : 222716-34-9
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1089 | In-stock | |
5 mg | ¥990 | In-stock | |
10 mg | ¥1800 | In-stock | |
25 mg | ¥3700 | In-stock | |
50 mg | ¥6500 | In-stock | |
100 mg | ¥11000 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
SZL P1-41 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Metabolism/Protease Compound Library
- Anti-Cancer Compound Library
- Oxygen Sensing Compound Library
- Ubiquitination Compound Library
- Glycolysis Compound Library
- Anti-Cancer Metabolism Compound Library
- Glucose Metabolism Compound Library
- Anti-Liver Cancer Compound Library
生物活性 |
SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities[1][2]. |
IC50 & Target |
Skp2[1] |
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
体外研究 (In Vitro) |
SZL P1-41 (5-20μM; 24 hours) induces endogenous p27 protein expression in PC3 cells and also induced expression of p21, another Skp2 substrate[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||
体内研究 (In Vivo) |
SZL P1-41 (40-80 mg/kg; i.p.) displays a potent effect on inhibiting prostate and lung tumor growth in Nude mice bearing A549 and PC3 tumor xenografts[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||
分子量 |
420.52 |
||||||||||||||||
Formula |
C24H24N2O3S |
||||||||||||||||
CAS 号 |
222716-34-9 |
||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 |
|
||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 2.5 mg/mL (5.95 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
||||||||||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务