艾菲地可宁
基本信息
| 产品名称 | 艾菲地可宁 |
|---|---|
| 英文名称 | Aphidicolin |
| 别名 | Aphidicolin |
| 英文别名 | APC |
| 应用 | A novel tetracyclic diterpene antibiotic and also a DNA synthesis inhibitor in eukaryotes |
| 规格或纯度 | 98% |
| 运输条件 | 冰袋运输 |
| 生化机理 | DNA聚合酶α，δ和ε抑制剂。四环二萜抗生素。真核细胞核DNA复制的可逆抑制剂。它在S期早期阻断细胞周期。 |
一般描述
Aphidicolin is a tetracyclic diterpene antibiotic and DNA synthesis inhibitor isolated from Cephalosporium aphidicola. Aphidicolin is reported to specifically inhibit DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases. This compound blocks the cell cycle at early S phase and has been reported to be useful for synchronizing cell cycles in cultured eukaryotic cells. This compound is also noted to induce apoptosis in HeLa S3 cells after 18-24 hours of the cell cycle.A novel tetracyclic diterpene antibiotic and also a DNA synthesis inhibitor in eukaryotes
Aphidicolin is a tetracyclic diterpene antibiotic and DNA synthesis inhibitor isolated from Cephalosporium aphidicola. Aphidicolin is reported to specifically inhibit DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases. This compound blocks the cell cycle at early S phase and has been reported to be useful for synchronizing cell cycles in cultured eukaryotic cells. This compound is also noted to induce apoptosis in HeLa S3 cells after 18-24 hours of the cell cycle.
A novel tetracyclic diterpene antibiotic and also a DNA synthesis inhibitor in eukaryotes
相关属性
| CAS编号 | 38966-21-1 |
|---|---|
| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in ethanol (1 mg/ml,stable at least a week at 4°C.), DMSO (10 mg/ml,stable at least six weeks at -20°C.), and methanol (10 mg/ml). Insoluble in water. |
| 储存温度 | 2-8°C储存 |
| RTECS | PB9185000 |
| MDL号 | MFCD00083214 |
| 密度 | 1.22 |
| 分子量 | 338.48 |
| 分子式 | C20H34O4 |
| 品牌 | Jinpan |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 457964 |