盐酸四环素
基本信息
| 产品名称 | 盐酸四环素 |
|---|---|
| 英文名称 | Tetracycline hydrochloride |
| 别名 | 四环素 盐酸盐 |
| 应用 | 作用模式: 靠阻止胺酰基-tRNA至核糖体30S亚单位上阻止蛋白的合成。 抗菌谱:革兰氏阴性和阳性细菌。 阻断模式: 细胞壁渗透性缺失。 |
| 规格或纯度 | USP级 |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Mode of Action: Tetracycline passively diffuses throμgh proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, sμggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drμg, that is responsible for antibacterial action. Mode of Resistance: The effects are inactivated via a loss of cell wall permeability. Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria. |
一般描述
溶解度:20 g/L水，5 g/L乙醇，不溶于醚、烃类和丙酮。 作用模式: 靠阻止胺酰基-tRNA至核糖体30S亚单位上阻止蛋白的合成。 抗菌谱:革兰氏阴性和阳性细菌。 阻断模式: 细胞壁渗透性缺失。
An antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing binding of aminoacyl tRNA to the A-site and blocking translocation. Used commonly for selection of the bacterial tetr gene whose product, a 399-amino acid membrane-associated protein, functions in active export of the drug from the cell. Broad-based antibiotic agent that blocks protein synthesis by inhibiting binding of aminoacyl tRNA to the A-site of ribosomes. Induces cold shock-response and enhances P450 expression in bacteria
Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis. It is recommended for use in cell culture applications at 10 mg/L.
相关属性
| CAS编号 | 64-75-5 |
|---|---|
| 敏感性 | 对光及空气敏感 |
| 比旋光度 | -253° (C=0.5,0.1mol/L HCl) |
| 熔点 | 223°C |
| 储存温度 | -20°C储存 |
| MDL号 | MFCD00078142 |
| 密度 | 1.177 |
| 分子量 | 480.9 |
| 分子式 | C22H24N2O8·HCl |
| EC号 | 200-593-8 |
| 品牌 | Jinpan |