Cas(2001-95-8), 缬氨霉素, ,Valinomycin,

发表于由

缬氨霉素

K +选择性离子载体
≥98% (TLC), ≥95% (HPLC)

有货

Cas(2001-95-8), 缬氨霉素,  ,Valinomycin,

CAS编号 2001-95-8 | 品牌：Jinpan
Valinomycin

MSDS

质检证书(CoA)

相似产品

  • 分子式 C54H90N6O18
  • 分子量1111.32
  • Beilstein号 78657
  • EC号 217-896-6
  • MDL号 MFCD00005114
  • PubChem编号 122173113

货号 (SKU) 包装规格 是否现货 价格 数量
V100895-5mg 5mg 期货 Cas(2001-95-8), 缬氨霉素,  ,Valinomycin,  
V100895-10mg 10mg 期货 Cas(2001-95-8), 缬氨霉素,  ,Valinomycin,  
V100895-50mg 50mg 期货 Cas(2001-95-8), 缬氨霉素,  ,Valinomycin,  
V100895-100mg 100mg 期货 Cas(2001-95-8), 缬氨霉素,  ,Valinomycin,  

基本信息

产品名称 缬氨霉素
英文名称 Valinomycin
英文别名 Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid;Lac = Lactic acid;NSC 122023
规格或纯度 ≥98% (TLC), ≥95% (HPLC)
运输条件 超低温冰袋运输
来源 Streptomyces fulvissimus
生化机理 K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.K + selective ionophore. Natural dodecadepsipeptide. Antitumor, antifungal and antibacterial effects. Apoptosis due to caspase independent mechanisms.

一般描述

Valinomycin is a cyclodepsipeptide and potassium ionophore that has been shown to induce cell death. The compound has been shown to have antibabesial activity and reported to promote hemolysis in HK erythrocytes, and decrease the intracellular ATP concentration. CHO cell studies demonstrate that cells exposed to Valinomycin display caspase-3 activation, phosphatidylserine membrane translocation, and mitochondrial membrane depolarization. Can be used as a biosensor to detect potassium efflux as well.A potassium ionophore shown to induce cell death;Being a Potassium selective ionophore, valinomycin is used in specific potassium measurment electrodes. Valinomycin is an apoptosis inducer. It is used as a tool in membrane research

Valinomycin is a cyclodepsipeptide and potassium ionophore that has been shown to induce cell death. The compound has been shown to have antibabesial activity and reported to promote hemolysis in HK erythrocytes, and decrease the intracellular ATP concentration. CHO cell studies demonstrate that cells exposed to Valinomycin display caspase-3 activation, phosphatidylserine membrane translocation, and mitochondrial membrane depolarization. Can be used as a biosensor to detect potassium efflux as well.
A potassium ionophore shown to induce cell death;Being a Potassium selective ionophore, valinomycin is used in specific potassium measurment electrodes. Valinomycin is an apoptosis inducer. It is used as a tool in membrane research

相关属性

CAS编号 2001-95-8
敏感性 对光、湿度敏感
熔点 190°C
溶解性 Soluble in ethanol (50 mg/ml), petroleum ether, ether, benzene, chloroform, glacial acetic, butyl acetate, and methanol (5 mg/ml). Soluble in DMSO at 10mg/ml. Insoluble in water
储存温度 避光,-20°C储存
RTECS YV9468000
MDL号 MFCD00005114
密度 1.06
分子量 1111.32
分子式 C54H90N6O18
EC号 217-896-6
品牌 Jinpan
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PubChem CID 122173113