氨基核苷嘌呤霉素
基本信息
| 产品名称 | 氨基核苷嘌呤霉素 |
|---|---|
| 英文名称 | Puromycin aminonucleoside |
| 别名 | 3′-Amino-3′-deoxy-N6,N6-dimethyladenosine;9-(3-Amino-3-deoxy-beta-D-ribofuranosyl)-6-(dimethylamino)-9H-purine; Aminonucleoside; Aminonucleoside puromycin;PANS |
| 英文别名 | 3′-Amino-3′-deoxy-N6,N6-dimethyladenosine;9-(3-Amino-3-deoxy-beta-D-ribofuranosyl)-6-(dimethylamino)-9H-purine; Aminonucleoside; Aminonucleoside puromycin;PANS |
| 规格或纯度 | 10mM in DMSO |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Puromycin aminonucleoside is used to study human glomerular disease by inducing damage of murine glomerular podocytes1 and is used to study glomerular function and morphology.Podocyte toxin, induces ROS and oxidant-dependent DNA damage in podocytes. Puromycin analogue that does not inhibit protein synthesis or induce DNA fragmentation. Antibiotic, antineoplastic and antimetabolite agent. Active in vivo and in vitro . |
一般描述
Puromycin Aminonucleoside (3′-Amino-3′-deoxy-N6,N6-dimethyladenosine) is the aminonucleoside portion of the antibiotic puromycin. It is a puromycin analog which does not inhibit protein synthesis or induce apoptosis. Used in the study of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and NOx metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome has been studied. Used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability
Puromycin Aminonucleoside (3′-Amino-3′-deoxy-N6,N6-dimethyladenosine) is the aminonucleoside portion of the antibiotic puromycin. It is a puromycin analog which does not inhibit protein synthesis or induce apoptosis. Used in the study of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and NOx metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome has been studied. Used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability
The aminonucleoside portion of the antibiotic puromycin.
相关属性
| CAS编号 | 58-60-6 |
|---|---|
| 敏感性 | 对光敏感 |
| 储存温度 | 避光,-80℃储存 |
| 分子量 | 294.31 |
| 分子式 | C12H18N6O3 |
| EC号 | 200-388-3 |
| 品牌 | Jinpan |
| PubChem CID | 6020 |