肉桂霉素

肉桂霉素（肉桂霉素）是由几种链霉菌产生的高分子量三环抗生素。肉桂霉素是一种有效的间接PLA2抑制剂（磷脂酶A2），通过特异性隔离哺乳动物血浆细胞膜的主要成分磷脂酰乙醇胺（PE）起作用。肉桂霉素诱导细胞膜中的跨双层磷脂运动，以暴露内部结合的PE。在PE的高表面浓度下，肉桂霉素诱导膜重组，包括膜融合和总体形态的改变。

Cinnamycin (lanthiopeptin) is a high molecular weight tricyclic antibiotic produced by several species of|Streptoverticillium|. Cinnamycin is a potent indirect inhibitor of PLA2 (phospholipase A2), acting by specifically sequestering phosphatidylethanolamine (PE), a major component of the mammalian plasma cell membrane. Cinnamycin induces trans-bilayer phospholipid movement in cell membranes to expose internally bound PE. At high surface concentrations of PE, cinnamycin induces membrane re-organization including membrane fusion and alteration of gross morphology.