Saccharocarcin B

Saccharocarcin B是与奇异霉素，氯霉素，tetrocarcins和versipelostatin在结构上相关的不寻常的tetronic酸，对革兰氏阳性细菌和沙眼衣原体具有明显的活性。该班的几名成员受到了相当多的文献关注。Versipelostatin已显示抑制GRP78启动子的转录，该基因在葡萄糖剥夺下作为应激信号通路的一部分被激活，导致未折叠的蛋白应答（UPR）。仅在葡萄糖剥夺的情况下才观察到UPR抑制作用，并且其导致葡萄糖剥夺的细胞的选择性和大量杀伤。Tetrocarcin A似乎靶向磷

Saccharocarcin B is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcins and versipelostatin which has pronounced activity against Gram positive bacteria and|Chlamydia trachomatis|. Several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3′-kinase/Akt signaling pathway.